Predictors of long‐term medication adherence in stroke survivors: A multicentre, prospective, longitudinal study

Yoo, Sung Hee; Kim, Gye‐Gyoung; Kim, Sung Reul; Park, Man‐Seok; Kim, Joon‐Tae; Choi, Kang‐Ho; Park, Hyun‐Young; Yi, SangHak; Cha, Jae‐Kwan; Kim, Dae‐Hyun; Nah, Hyun‐Wook

doi:10.1111/jocn.16472

Cited by 6 publications

(5 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study confirmed that medication belief was significantly associated with adherence. Specifically, necessity belief is positively linked to medication adherence, while concern belief has the opposite effect, which was consistent with other published studies reporting that a strong medication belief had a positive impact on medication adherence ( Chua et al, 2018 ; Yoo et al, 2023 ). The overall score of medication belief was greater than “zero”, indicating that patients perceived more benefits than risks of oral anticoagulants.…”

Section: Discussionsupporting

confidence: 91%

Adherence, belief, and knowledge about oral anticoagulants in patients with bioprosthetic heart valve replacement: a cross-sectional study

Liu

Feng

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Aims: To investigate adherence to oral anticoagulants among patients after mechanical heart valve (BHV) replacement and further examine the mediating role of medication belief in the relationship between knowledge and medication adherence.Background: The number of patients who undergo BHV replacement has increased in recent years. Short-term anticoagulant therapy is recommended for patients after BHV replacement. However, little is known about adherence to oral anticoagulant therapy and the underlying mechanisms among patients with BHV replacement.Methods: A cross-sectional study was conducted between September 2022 and November 2022. A convenience sample of 323 patients who underwent BHV replacement was recruited from a tertiary public hospital in Southwest China. Data were collected by using the 8-item Morisky Medication Adherence Scale, Beliefs about Medicines Questionnaire-specific, and the Knowledge of Anticoagulation Questionnaire. The mediation model was tested by Hayes’s PROCESS macro. The STROBE checklist was used.Results: Approximately 17.3% of participants had low adherence, 47.1% had medium adherence, and only 35.6% reported high adherence to oral anticoagulants. Knowledge and necessity beliefs were positively related to medication adherence, while concern beliefs were negatively correlated with medication adherence. Medication belief mediated the relationship between knowledge and adherence to oral anticoagulants.Conclusion: Patients with BHV replacement demonstrated relatively low adherence to oral anticoagulant therapy. Efforts to enhance medication adherence should consider improving patients’ knowledge and medication beliefs.

show abstract

Section: Discussionsupporting

confidence: 91%

Adherence, belief, and knowledge about oral anticoagulants in patients with bioprosthetic heart valve replacement: a cross-sectional study

Liu

Feng

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Considering that a significantly higher proportion of respondents were disabled (2.8% vs. 0.0%) and consumed more than two medications (76.4% vs. 32.0%), as well as a lower proportion of normal workers (9.7% vs. 20.8%) in the PSD group, we speculate that this counterintuitive result might be mainly due to the stronger belief in taking medicine in the PSD population, which is inspired by an intensive willingness to alleviate pain due to severe post-stroke complications, including dysphagia. Strong medication beliefs, as suggested by recent studies [41][42][43], are strongly associated with medication adherence in stroke patients, partly supporting our inference. Additionally, we corroborated the findings of other related studies on the positive correlation of old age and male sex with medication compliance in stroke patients [42][43][44], further enhancing the credibility of our study on the counterintuitive results discussed above.…”

Section: Discussionsupporting

confidence: 91%

“…Strong medication beliefs, as suggested by recent studies [41][42][43], are strongly associated with medication adherence in stroke patients, partly supporting our inference. Additionally, we corroborated the findings of other related studies on the positive correlation of old age and male sex with medication compliance in stroke patients [42][43][44], further enhancing the credibility of our study on the counterintuitive results discussed above.…”

Section: Discussionsupporting

confidence: 91%

Status quo, perception, and preference of secondary prevention medications in post-stroke dysphagia patients: Time to raise awareness and develop special formulations

Yu,

Yang,

Katas

2024

Preprint

View full text Add to dashboard Cite

Post-stroke dysphagia (PSD) is an increasingly common complication of stroke. Despite its intuitively unfavorable impact on secondary prevention medication use, limited awareness is available regarding this issue. Herein, a cross-sectional survey was conducted to determine the current use, patient-perceived needs and preferences for secondary prevention medications among PSD patients. To highlight the special situation arising from dysphagia, Chinese stroke patients with a duration of under five years were recruited and categorized into PSD and non-PSD groups by initial survey. Only the PSD group continued the needs and preference surveys. Among the 3,490 eligible respondents, 42.7% reported experiencing dysphagia after stroke. Those PSD respondents were more likely to consume multiple medications and suffer from anticoagulants-associated gastrointestinal bleeding as compared to non-PSD ones (p<0.001). More crucially, 40.2% of them had frequent difficulty in swallowing pills, 37.1% routinely crushed solid oral dosage forms (SODFs), and 23.5% coughed frequently when taking SODFs. In consequence, 87.4% responded a need for PSD-specific formulations where safe swallowing, easy swallowing, and reduced medication frequency were preferred pharmaceutical factors.These findings demonstrate an unsatisfactory situation and definite needs for PSD patients in using secondary prevention medications. Awareness should be increased to develop PSD-specific formulations for safe and effective secondary prevention.

show abstract

“…The 3-months medication adherence in these 2 groups was higher than that of previous studies [9,36]. However, it is still lower than the 89.0% medication adherence reported in a study of 600 patients conducted in 3 stroke centers across Korea [37]. Only patients who continued to take all prescribed medications were further evaluated for adherence, resulting in the exclusion of patients who reported discontinuing all or some medications, which may explain this difference.…”

Section: Principal Findingscontrasting

confidence: 56%

Effects of a Planned Web-Based Educational Intervention Based on the Health Belief Model for Patients With Ischemic Stroke in Promoting Secondary Prevention During the COVID-19 Lockdown in China: Quasi-Experimental Study

Liu,

Sun,

Guo

et al. 2024

JMIR Mhealth Uhealth

View full text Add to dashboard Cite

Background Some common modified vascular risk factors remain poorly controlled among stroke survivors, and educational programs may help improve these conditions. Objective This study aimed to evaluate the effect of a planned web-based educational intervention based on the health belief model (HBM) in promoting secondary prevention among patients with ischemic stroke. Methods An evaluation-blinded quasi-experimental trial with a historical control group was conducted. Patients admitted from March to June 2020 were assigned to the historical control group, and patients admitted from July to October 2020 were assigned to the intervention group. The control group received routine health management. The intervention group received 6 additional sessions based on the HBM via Tencent Meeting, an audio and video conferencing application, within 3 months after discharge. Sessions were held every 2 weeks, with each session lasting approximately 40 minutes. These sessions were conducted in small groups, with about 8 to 10 people in each group. The primary outcomes were changes in blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), hemoglobin A1c (HbA1c), and the proportion of patients achieving the treatment target. The secondary outcomes were medication adherence, assessed with the Morisky Medicine Adherence Scale (MMAS), and disability, assessed with the modified Rankin scale. Results In total, 315 patients experiencing their first-ever stroke were analyzed. More patients in the intervention group had controlled BP (41.9% vs 28.4%; adjusted odds ratio [aOR] 1.93; P=.01), LDL-C (83.1% vs 67.7%; aOR 2.66; P=.001), and HbA1c (91.9% vs 83.9%; aOR: 3.37; P=.04) levels as well as a significant postintervention decrease in the systolic BP (adjusted β −3.94; P=.02), LDL-C (adjusted β −0.21; P=.008), and HbA1c (adjusted β −0.27; P<.001), compared with control groups. Significant between-group differences were observed in medication adherence (79.4% vs 63.2%; aOR 2.31; P=.002) but not in favorable functional outcomes. Conclusions A web-based education program based on the HBM may be more effective than current methods used to educate patients having strokes on optimal vascular risk factors and medication adherence.

show abstract

Predictors of long‐term medication adherence in stroke survivors: A multicentre, prospective, longitudinal study

Cited by 6 publications

References 64 publications

Adherence, belief, and knowledge about oral anticoagulants in patients with bioprosthetic heart valve replacement: a cross-sectional study

Adherence, belief, and knowledge about oral anticoagulants in patients with bioprosthetic heart valve replacement: a cross-sectional study

Status quo, perception, and preference of secondary prevention medications in post-stroke dysphagia patients: Time to raise awareness and develop special formulations

Effects of a Planned Web-Based Educational Intervention Based on the Health Belief Model for Patients With Ischemic Stroke in Promoting Secondary Prevention During the COVID-19 Lockdown in China: Quasi-Experimental Study

Contact Info

Product

Resources

About