Predictors of major vascular events in patients with a transient ischemic attack or nondisabling stroke. The Dutch TIA Trial Study Group.

doi:10.1161/01.str.24.4.527

Cited by 74 publications

(10 citation statements)

References 13 publications

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“…As in other studies, the incidence of retinal infarctions was low [19, 23, 25, 27]. Overall, patients with TMB associated with atheromatous disease have a lower risk of ipsilateral stroke than patients with cerebral TIA [5, 6]. In contrast, we found that the risk of cardiac disease in patients with TMB was not lower than that reported in studies on cerebral TIA [23, 28].…”

Section: Discussionsupporting

confidence: 71%

“…Upward resolution of visual field loss might occur when restriction of blood flow to the lower part of the retina is restored last. In other cohorts of patients with TMB or TIA in general, the occurrence of multiple attacks has also been found to predict recurrent vascular events [4, 6]. Involvement of the peripheral, but not the central area of the visual field was identified as the most powerful predictor of impending vascular disease in our study.…”

Section: Discussionsupporting

confidence: 65%

“…The incidence, prognosis and treatment of TMB in general have been extensively studied in both community and hospital based studies [3, 4, 6, 23–26]. In our cohort, the overall annual incidence of cardiovascular complications was 4.4 % (95 % CI 3.4–5.7 %), which is somewhat higher than in more recent studies [4].…”

Section: Discussioncontrasting

confidence: 52%

“…In general, patients with TMB associated with atheromatous disease in the carotid artery have an average 1 year risk of recurrent stroke of 2 % [3, 4], but in patients with severe ICA stenosis the risk of ipsilateral stroke is up to 16 % after 3 years [5]. Overall, the risk is two to three times lower than in patients with cerebral TIA [5, 6]. …”

Section: Introductionmentioning

confidence: 99%

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Transient monocular blindness and the risk of vascular complications according to subtype: a prospective cohort study

et al. 2016

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Patients with transient monocular blindness (TMB) can present with many different symptoms, and diagnosis is usually based on the history alone. In this study, we assessed the risk of vascular complications according to different characteristics of TMB. We prospectively studied 341 consecutive patients with TMB. All patients were interviewed by a single investigator with a standardized questionnaire; reported symptoms were classified into predefined categories. We performed Cox regression analyses with adjustment for baseline vascular risk factors. During a mean follow-up of 4.0 years, the primary outcome event of vascular death, stroke, myocardial infarction, or retinal infarction occurred in 60 patients (annual incidence 4.4 %, 95 % confidence interval (CI) 3.4-5.7). An ipsilateral ischemic stroke occurred in 14 patients; an ipsilateral retinal infarct in six. Characteristics of TMB independently associated with subsequent vascular events were: involvement of only the peripheral part of the visual field (hazard ratio (HR) 6.5, 95 % CI 3.0-14.1), constricting onset of loss of vision (HR 3.5, 95 % CI 1.0-12.1), downward onset of loss of vision (HR 1.9, 95 % CI 1.0-3.5), upward resolution of loss of vision (HR 2.0, 95 % CI 1.0-4.0), and the occurrence of more than three attacks (HR 1.7, 95 % CI 1.0-2.9). We could not identify characteristics of TMB that predicted a low risk of vascular complications. In conclusion, careful recording the features of the attack in patients with TMB can provide important information about the risk of future vascular events.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionsupporting

confidence: 65%

Section: Discussioncontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

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Transient monocular blindness and the risk of vascular complications according to subtype: a prospective cohort study

et al. 2016

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“…In the Dutch TIA Trial, 997 patients with TIA and 2,130 patients with minor stroke were enrolled for 2 year risk analysis for outcomes of fatal or non-fatal stroke in addition to myocardial infarction, stroke, or vascular death (7). It identified the following independent risk factors for stroke, myocardial infarction or vascular death: age > 65 years; male sex; dysarthria; multiple attacks; diabetes; angina pectoris; intermittent claudication; computed tomographic evidence of any cerebral infarct especially a border zone infarct or white matter hypodensity; and electrocardiographic evidence of anteroseptal infarct, ST depression, left ventricular hypertrophy, or left atrial conduction delay.…”

Section: Resultsmentioning

confidence: 99%

Clinical Risk Score for Predicting Recurrence Following a Cerebral Ischemic Event

Chaudhary

Abedi

et al. 2019

Front. Neurol.

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Introduction: Recurrent stroke has a higher rate of death and disability. A number of risk scores have been developed to predict short-term and long-term risk of stroke following an initial episode of stroke or transient ischemic attack (TIA) with limited clinical utilities. In this paper, we review different risk score models and discuss their validity and clinical utilities.Methods: The PubMed bibliographic database was searched for original research articles on the various risk scores for risk of stroke following an initial episode of stroke or TIA. The validation of the models was evaluated by examining the internal and external validation process as well as statistical methodology, the study power, as well as the accuracy and metrics such as sensitivity and specificity.Results: Different risk score models have been derived from different study populations. Validation studies for these risk scores have produced conflicting results. Currently, ABCD2 score with diffusion weighted imaging (DWI) and Recurrence Risk Estimator at 90 days (RRE-90) are the two acceptable models for short-term risk prediction whereas Essen Stroke Risk Score (ESRS) and Stroke Prognosis Instrument-II (SPI-II) can be useful for prediction of long-term risk.Conclusion: The clinical risk scores that currently exist for predicting short-term and long-term risk of recurrent cerebral ischemia are limited in their performance and clinical utilities. There is a need for a better predictive tool which can overcome the limitations of current predictive models. Application of machine learning methods in combination with electronic health records may provide platform for development of new-generation predictive tools.

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Predictive Value of Clinical History and Electrocardiogram in Patients With Transient Ischemic Attack or Minor Ischemic Stroke for Subsequent Cardiac and Cerebral Ischemic Events

Pop¹,

Koudstaal²,

Meeder³

et al. 1994

Archives of Neurology

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Predictors of major vascular events in patients with a transient ischemic attack or nondisabling stroke. The Dutch TIA Trial Study Group.

Cited by 74 publications

References 13 publications

Transient monocular blindness and the risk of vascular complications according to subtype: a prospective cohort study

Transient monocular blindness and the risk of vascular complications according to subtype: a prospective cohort study

Clinical Risk Score for Predicting Recurrence Following a Cerebral Ischemic Event

Predictive Value of Clinical History and Electrocardiogram in Patients With Transient Ischemic Attack or Minor Ischemic Stroke for Subsequent Cardiac and Cerebral Ischemic Events

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