Predictors of meaningful improvement in quality of life after selective amygdalohippocampectomy in Chinese patients with refractory temporal lobe epilepsy: A prospective study

Quality of life long after temporal lobe epilepsy surgery

“…16,27 The Using distributional methods, 14,17 most of the MTLE-HS patients had a MCIC of QOL by specific inventory for epilepsy one year after epilepsy surgery. [11][12][13][14] The highest rates of MCIC were in the domains seizure worry and social functioning. The improvement of each domain of Q OLIE varies among studies, most of them showing a better outcome in overall QOL, health perception, psychological function, and epilepsy-related domains.…”

“…The present study highlights the absence of depression at longterm assessment as the only significant predictor of QOL, but not the occurrence of pre-surgical depression. Pre-surgical psychiatric diagnoses, [10][11][12][13]16,30 and the presence of depression before surgery have been associated with a worse QOL outcome one year after surgery, 11,16 which is a relatively short period. It might be possible that considering a longer time of follow-up and, for most of the patients, more extended time of better seizure control, the influence of pre-surgical variables become less relevant.…”

“…3,[11][12][13][14] The literature has shown that depressive symptoms may better predict QOL than lack of seizure control among patients with refractory epilepsy. 3,15,16 Pre-surgical depression has been reported as predicting lack of QOL improvement one year after epilepsy surgery, [11][12][13][14] and little is known about predictors of QOL changes long after epilepsy surgery. 16 Moreover, information about minimum clinically important change (MCIC) of QOL improvement is also scarce.…”

“…16 Moreover, information about minimum clinically important change (MCIC) of QOL improvement is also scarce. [12][13][14] MCIC means relevant change for the patient. It can be determined by distributional or patient-reported methods.…”

“…The occurrence of pre-surgical depression and complete seizure control after temporal lobe surgery is independent predictors for meaningful improvement in QOL one year after anterior and mesial temporal lobectomy (ATL) in patients from Canada, 17 Brazil, 12 and China. 13 However, it remains unknown whether meaningful improvement in QOL persists permanently after surgery and which variables might predict it. Additionally, the long-term occurrence and influence of depression and anxiety symptoms after surgery on QOL are unknown.…”