Predictors of mortality and morbidity in extremely low birth weight neonates

Eichenwald, Eric C.

doi:10.1007/s13312-013-0291-x

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…The mortality among ELBW babies was high (88%), while it was 49.78% among VLBW babies and 19.02% among LBW babies. This result was greater than other studies done, in India [30,31], Johannesburg [32], Northeast Brazil [33], and Mexico City [34]. The reported higher birth weight-specific NMRs in the current study could be partly due to complications of PTBs since the majority (79%) of the babies in this study were extremely and/or very preterm and they might have a difficult time eating, to get back their birthweight and fight infections.…”

Section: Plos Onecontrasting

confidence: 71%

Survival status and predictors of mortality among low-birthweight neonates admitted to KMC units of five public hospitals in Ethiopia: Frailty survival regression model

et al. 2022

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Background Low birth weight (LBW) and preterm birth are leading causes of under-five and neonatal mortality globally. Data about the timing of death and outcomes for LBW and preterm births are limited in Ethiopia and could be used to strengthen neonatal healthcare. This study describes the incidence of neonatal mortality rates (NMR) stratified by newborn size at birth for gestational age and identifies its predictors at five public hospitals in Ethiopia. Methods A prospective follow-up study enrolled 808 LBW neonates from March 2017 to February 2019. Sex-specific birthweight for gestational age percentile was constructed using Intergrowth 21st charts. Mortality patterns by birthweight for-gestational-age-specific survival curves were compared using the log-rank test and Kaplan-Meier survival curves. A random-effects frailty survival model was employed to identify predictors of time to death. Results Among the 808 newborns, the birthweight distribution was 3.2% <1000 g, 28.3% <1500 g, and 68.1% <2000 g, respectively. Birthweight for gestational age categories were 40.0% both preterm and small for gestational age (SGA), 20.4% term SGA, 35.4% appropriate weight for gestational age, and 4.2% large for gestational age (LGA). The sample included 242 deaths, of which 47.5% were both preterm and SGA. The incidence rate of mortality was 16.17/1000 (95% CI 14.26–18.34) neonatal-days of observation. Neonatal characteristics independently related to increased risk of time-to-death were male sex (adjusted hazards ratio [AHR] 3.21 95% CI 1.33–7.76), born preterm (AHR 8.56 95% CI 1.59–46.14), having been diagnosed with a complication (AHR 4.68 95% CI 1.49–14.76); some maternal characteristics and newborn care practices (like lack of effective KMC, AHR 3.54 95% CI 1.14–11.02) were also significantly associated with time-to-death. Conclusions High mortality rates were measured for low birthweight neonates–especially those both preterm and SGA births–even in the context of tertiary care. These findings highlight the need for improved quality of neonatal care, especially for the smallest newborns.

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Section: Plos Onecontrasting

confidence: 71%

Survival status and predictors of mortality among low-birthweight neonates admitted to KMC units of five public hospitals in Ethiopia: Frailty survival regression model

et al. 2022

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“…Studies in other low‐income countries showed higher mortality rates in very low birth weight infants. The mortality rate was 48% in 2010 India [8], 29.5% in South Africa [7], 50% in India in 2013 [10], and 33% in Iran (in infants with birth weight less than 1500 g [9]). However, these studies involved only infants with very low birth weight (< 1500 g in many cases) and focused on low birth weight infants admitted in the hospital neonatal units.…”

Section: Discussionmentioning

confidence: 99%

“…Neonatal and infant mortality rates remain high in low‐income countries [5,6]. This is due to multiple determinants including environmental, sociocultural, sociodemographic, and clinical factors [7–15]. The limited improvement in child health indicators calls for altering future plans by targeting high‐risk groups such as low birth weight infants because they are the focus of new research priorities in the post‐MDG period [16–18].…”

Section: Introductionmentioning

confidence: 99%

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Predictors of mortality of low birth weight newborns during the neonatal period: A cohort study in two health districts of Burkina Faso

Coulibaly

Baguiya

Millogo³

et al. 2016

Intl J Gynecology & Obste

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“…Similarly, Gera and Ramji [5] found a mortality of 40.86%. In their study, 115 participants were enrolled, out of these 47 died; 36 (76.5%) in the early neonatal period and the rest (23.5%) in the late neonatal period.…”

Section: Discussionmentioning

confidence: 80%

To Study the Effect of Maternal Factors on Mortality of Very Low Birth Weight Neonates

HARINKHEDE,

KUMAR PATEL,

NAGWANSHI

et al. 2023

Asian J Pharm Clin Res

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Objectives: The present study is to determine the influences of maternal risk factors on neonatal mortality in very low birth weight (VLBW) infants born in central India. Methods: A nested case–control study was conducted in the prospectively assembled cohort at the Department of Pediatrics Government Medical College and Hospital, Nagpur, India, for 2 years. Intramural neonates admitted to NICU with a birth weight of 500–1500 g were included in the study. Newborns with major congenital malformation and those who died in the delivery room or within 12 h of birth were excluded from the study. Results: A total of 260 inborn VLBW newborns admitted to the NICU were enrolled. The mean gestational age was 33.58±4.8 weeks, and the mean birth weight was 1256.56±182.8 g. The overall case fatality rate was 50.38%. Maternal body mass index (BMI) <18.5 g/m2 (p=0.0019 [(Odds Ratio [OR]=3.23) (95% confidence interval [CI]. 1.43–7.80)]) and ante partum hemorrhage (p=0.0001[(OR=3.57) (95% CI 1.82–7.22)]) were two maternal factors which significantly increased the risk of death. However, antenatal steroid coverage (p=0.0005 [(OR=2.25) (95% CI 1.12–5.35)]) was associated with improved survival of VLBW neonates. Conclusion: It can be said that very low birth neonates, especially those weighing <1000 g, preterm, and who are critically ill due to disturbance in pulmonary and circulatory physiology have a very high risk of mortality. Low maternal BMI and antepartum hemorrhage in mothers of VLBW neonate were associated with increased neonatal mortality and ACS therapy was associated with decreased neonatal mortality.

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Predictors of mortality and morbidity in extremely low birth weight neonates

Cited by 4 publications

References 8 publications

Survival status and predictors of mortality among low-birthweight neonates admitted to KMC units of five public hospitals in Ethiopia: Frailty survival regression model

Survival status and predictors of mortality among low-birthweight neonates admitted to KMC units of five public hospitals in Ethiopia: Frailty survival regression model

Predictors of mortality of low birth weight newborns during the neonatal period: A cohort study in two health districts of Burkina Faso

To Study the Effect of Maternal Factors on Mortality of Very Low Birth Weight Neonates

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