Predictors of mortality following treatment of intracranial hemangiopericytoma

Rutkowski, Martin J.; Sughrue, Michael E.; Kane, Ari J.; Aranda, Derick; Mills, Steven A.; Barani, Igor J.; Parsa, Andrew T.

doi:10.3171/2010.3.jns091882

Cited by 121 publications

(144 citation statements)

References 86 publications

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“…The effective radiation dose is quoted by most studies to be [50 Gy [17][18][19][21][22][23][24]. In a recent systematic review of 563 intracranial HPCs cases (277 had follow-up data), Rutkowski et al [25] reported that patients receiving [50 Gy of radiation had worse survival outcomes (median Table 2 Cases of hemangiopericytoma of the spine described in present and previous reports survival 4 vs. 18.6 years, p \ 0.01). This study notes the possibility of selection biases in tumor quality and more aggressive tumors receiving higher doses.…”

Section: Adjuvant Treatmentmentioning

confidence: 98%

Surgical management of primary spinal hemangiopericytomas: an institutional case series and review of the literature

et al. 2013

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Purpose Hemangiopericytoma (HPC) is a rare tumor of the central nervous system. Primary spinal occurrence of this tumor is extremely uncommon and cases involving the intramedullary spinal cord are even more rare. The purpose of this study was to explore the clinical features, surgical strategies, outcome and pathology in a consecutive series of patients treated at a single institution. Methods The authors performed a retrospective review of the clinicopathological characteristics of four patients with a pathological diagnosis of spinal HPC. Results Four cases with intradural as well as intra/extramedullary components were identified. Gross total resection with no recurrence at the operative site was achieved in the majority of patients with a spinal HPC. One patient had significant recurrence and eventually, succumbed to the disease. Conclusion Increased awareness of these tumors' capability to occur intradurally and intramedullarly can help surgeons accurately diagnose and choose an effective plan of care. Gross total resection of hemangiopericytomas is the mainstay of treatment and should be pursued if feasible. Histopathology is essential to the diagnosis.

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Section: Adjuvant Treatmentmentioning

confidence: 98%

Surgical management of primary spinal hemangiopericytomas: an institutional case series and review of the literature

et al. 2013

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“…4 Histologically, hemangiopericytoma arises from pericytes of Zimmerman or pericapillary cells and can occur anywhere where capillaries are found. 2,8,9 It has been classified as a mesenchymal tumor of the meninges and further subclassified into 2 histologic types, hemangiopericytoma and anaplastic hemangiopericytoma (corresponding to WHO grades II or III) by the WHO in 2007. 10 The literature on CT and MR imaging of intracranial meningeal hemangiopericytomas is currently limited.…”

mentioning

confidence: 99%

Intracranial Meningeal Hemangiopericytomas in Children and Adolescents: CT and MR Imaging Findings

Chen¹,

Chen²,

Wang³

et al. 2011

AJNR Am J Neuroradiol

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SUMMARY:Intracranial meningeal hemangiopericytomas in children and adolescents are prone to bleeding during surgery. CT and MR imaging may serve a role in preoperative diagnosis. The purpose of this report was to describe the radiologic findings in 9 pathologically proved cases of intracranial meningeal hemangiopericytomas in children and adolescents. The average duration of symptoms was short (mean, 4.0 months; median, 1.5 months). The intraoperative blood loss was large (mean, 3561 mL; median, 1000 mL). Tumors were extra-axial, irregularly multilobular, and hypervascular. Radiologically, they showed mixed attenuation on precontrast CT images, heterogeneous signal intensity on precontrast MR imaging, and marked and heterogeneous enhancement on postcontrast MR imaging. Bone erosion was sometimes present, but hyperostosis was not present. On MR imaging, multiple signal intensity voids of vessels were observed in 100% (8/8) of tumors with AVM-like signal intensity flow voids in 25% (2/8) of tumors. These results suggest that CT and MR imaging findings may be helpful for preoperative diagnosis.

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“…The median survival from the time of diagnosis is approximately 13 years. 24 Dural metastasis can also look like meningiomas, with a similar enhancing pattern and dural tail. It is estimated that dural metastases are found in 8%-9% of patients with advanced systemic cancer at autopsy.…”

Section: Lesions Mimicking Meningiomasmentioning

confidence: 99%

“…Hemangiopericytoma is a rare intracranial malignancy believed to represent 2%-3% of all primary meningeal tumors. 24 Hemangiopericytomas were initially considered a subgroup of meningioma (angioblastic variant), 1 but since 1993 the WHO has classified them as a distinct entity. 27 Hemangiopericytomas are known for their aggressive behavior, high recurrence rate, and potential for metastasis.…”

Section: Lesions Mimicking Meningiomasmentioning

confidence: 99%

Incidental meningiomas

Chamoun¹,

Krisht²,

Couldwell³

2011

FOC

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With the increasing availability and use of modern brain diagnostic imaging modalities, discovery of incidental meningiomas has become fairly common. This creates a dilemma among neurosurgeons as to whether these lesions should be treated. Numerous natural history studies have been published in an effort to shed light on the potential for growth of incidental meningiomas. The available data appear to suggest that these tumors can fall into 1 of 3 main growth patterns: no growth, linear growth, or exponential growth. The therapeutic strategy selected should also consider several other factors, mainly the risk of complications from an eventual surgery, the possibility of malignancies and other pathological conditions that mimic meningiomas, and the age and medical condition of the patient. The authors believe that most asymptomatic incidental meningiomas can be observed using serial imaging and clinical follow-up evaluations. Surgical interventions are typically reserved for large, symptomatic lesions and those with documented potential for significant growth.

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Predictors of mortality following treatment of intracranial hemangiopericytoma

Abstract: Treatment with gross-total resection provides the greatest survival advantage and should be pursued aggressively as an initial therapy. The addition of postoperative adjuvant radiation does not seem to confer a survival benefit.

Cited by 121 publications

References 86 publications

Surgical management of primary spinal hemangiopericytomas: an institutional case series and review of the literature

Surgical management of primary spinal hemangiopericytomas: an institutional case series and review of the literature

Intracranial Meningeal Hemangiopericytomas in Children and Adolescents: CT and MR Imaging Findings

Incidental meningiomas

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