Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2

Du, Ronghui; Liang, Lirong; Yang, Chengqing; Wang, Wen; Cao, Tanze; Li, Ming; Guo, Guangyun; Du, Juan; Zheng, Chunlan; Zhu, Qi; Hu, Ming; Li, Xuyan; Peng, Peng; Shi, Honglei

doi:10.1183/13993003.02961-2020

Cited by 37 publications

(24 citation statements)

References 6 publications

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“…New laboratory biomarkers could be identified through the accurate analysis of multicentric case series; in particular, homocysteine and angiotensin II could play a significant role in this regard 24 . Some studies have reported elevated WBC, CRP, LDH, CK, and troponin associated with the severity of COVID-19 25 , 26 . Dry cough, fever and fatigue commonly occur in the early stages of COVID-19, however, ARDS, acute respiratory failure, multi-organ failure, and sepsis are also quickly developed in some patients 27 .…”

Section: Introductionmentioning

confidence: 99%

Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality

Ali

Noman

Guo

et al. 2021

Sci Rep

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Since the emergence of SARS-CoV-2, numerous studies have been attempting to determine biomarkers, which could rapidly and efficiently predict COVID-19 severity, however there is lack of consensus on a specific one. This retrospective cohort study is a comprehensive analysis of the initial symptoms, comorbidities and laboratory evaluation of patients, diagnosed with COVID-19 in Huoshenshan Hospital, Wuhan, from 4th February to 12th March, 2020. Based on the data collected from 63 severely ill patients from the onset of symptoms till the full recovery or demise, we found not only age (average 70) but also blood indicators as significant risk factors associated with multiple organ failure. The blood indices of all patients showed hepatic, renal, cardiac and hematopoietic dysfunction with imbalanced coagulatory biomarkers. We noticed that the levels of LDH (85%, P < .001), HBDH (76%, P < .001) and CRP (65%, P < .001) were significantly elevated in deceased patients, indicating hepatic impairment. Similarly, increased CK (15%, P = .002), Cre (37%, P = 0.102) and CysC (74%, P = 0.384) indicated renal damage. Cardiac injury was obvious from the significantly elevated level of Myoglobin (52%, P < .01), Troponin-I (65%, P = 0.273) and BNP (50%, P = .787). SARS-CoV-2 disturbs the hemolymphatic system as WBC# (73%, P = .002) and NEUT# (78%, P < .001) were significantly elevated in deceased patients. Likewise, the level of D-dimer (80%, P < .171), PT (87%, P = .031) and TT (57%, P = .053) was elevated, indicating coagulatory imbalances. We identified myoglobin and CRP as specific risk factors related to mortality and highly correlated to organ failure in COVID-19 disease.

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Section: Introductionmentioning

confidence: 99%

Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality

Ali

Noman

Guo

et al. 2021

Sci Rep

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“… China 12 52 64.6 8 Aggarwal et al, 2020 [ 63 ] January 31, 2020. China 33 191 17.27749 7 Saleh et al, 2020 [ 65 ] March to April 2020 USA 3 42 7.142857 10 Hong et al, 2020 [ 77 ] March to May 2020 Iran 115 386 29.79275 10 Javanian et al, 2020 [ 78 ] 29-Mar-20 South Korea 11 98 11.22449 8 Lombardi et al, 2020 [ 79 ] Feb 25 to March 12, 2020 Iran 14 100 14 9 Du et al, 2020 [ 25 ] March 1 to April 9, 2020 Italy 45 614 7.32899 10 Xu et al, 2020 [ 80 ] August 2020 China 14 179 7.821229 10 …”

Section: Resultsmentioning

confidence: 99%

“…The coronavirus disease 2019 affects mainly the respiratory system through which the patient may end up with rapidly progressing pneumonia and acute respiratory distress syndrome [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] ] despite current works of literature on the clinical manifestation of the gastrointestinal tract, cardiac, dermatologic, and central nervous system [ [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] ]. However, the body of evidence showed that cardiovascular disorders particularly acute myocardial injury is getting attention as a result of associated short-term and long-term significant morbidity and mortality [ 6 , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] ].…”

Section: Introductionmentioning

confidence: 99%

Global burden of acute myocardial injury associated with COVID-19: A systematic review, meta-analysis, and meta-regression

Abate

Mantefardo

Nega

et al. 2021

Annals of Medicine &Amp; Surgery

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Background The body of evidence showed that there is a strong correlation between acute myocardial Injury and COVID-19 infection. However, the link between acute myocardial infection and COVID-19, the prevalence, reliability of diagnostic modalities, independent predictors, and clinical outcomes are still uncertain and a topic of debate. The current study was designed to determine the prevalence, determinants, and outcomes of acute myocardial injury based on a systematic review and meta-analysis the global published peer-reviewed works of literature. Methods A comprehensive search was conducted in PubMed/Medline; Science direct, CINHAL, and LILACS from December 2019 to May 2021. All observational studies reporting the prevalence of AMI were included while case reports and reviews were excluded. The data were extracted with two independent authors in a customized format. The methodological quality of included studies was evaluated using the Newcastle-Ottawa appraisal tool. Results A total of 397 articles were identified from different databases. Thirty-seven Articles with 21, 204 participants were included while seven studies were excluded. The meta-analysis revealed that the pooled prevalence of myocardial injury during the COVID-19 pandemic was 22.33 % (95 % CI: 17.86 to 26.81, 37). Conclusion Our meta-analysis showed that mortality among patients with an acute myocardial injury during COVID-19 was more than four times more likely as compared to those without AMI. This necessitates a mitigating strategy to prevent and manage before its clinical outcomes getting worse.

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“…Moreover, in a prospective study, CD3+ CD8+ T-cells 75 cells•μL −1 was a reliable predictor for mortality of patients with COVID-19 infection. It seems that CD3+ T-cells are the major type that is supressed in infected patients and this depletion is associated with an adverse outcome due to cytokine storm [43] [44].…”

Section: White Blood Cell Populationmentioning

confidence: 99%

Review of the Prognosis Factors of COVID-19 Infection

Besteiro¹,

Coutinho²,

Gomes³

et al. 2021

AID

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An epidemic of Coronavirus disease 2019 outbroke in December 2019 in China, Wuhan, which is becoming a Public Health Emergency of International Concern. As this entity has become one of the worst infectious disease outbreaks of recent times, with mortality estimates in general population ranging from 1.4% to 8%, it is crucial to better understand the prognostic factors which can be associated to the outcome of this disease. However, as the pandemic is still unfortunately under progression, there are limited data with regard to the prognostic factors. Hence, this review seeks to gather and provide the existing data of the literature of all the prognosis factors of COVID-19 infection such as older age, obesity, comorbidities, lymphocytopenia, d-dimers elevation, thrombocytopenia, elevated levels of high-sensitivity cardiac troponin, C-reactive protein elevation and imaging features of COVID-19.

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Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2

Cited by 37 publications

References 6 publications

Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality

Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality

Global burden of acute myocardial injury associated with COVID-19: A systematic review, meta-analysis, and meta-regression

Review of the Prognosis Factors of COVID-19 Infection

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