Predictors of mortality in COPD patients after hospitalization due to an exacerbation

Lahosa, Carolina; Fernández-Presa, Lucía; Bocigas, Irene; Miñana, Jaime Signes-Costa; Safont, Belén; González, Cruz; Servera, Emilio

doi:10.1183/13993003.congress-2019.pa5224

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16,17 Age is one of the risk factor that is associated with increased in-hospital mortality, one such reason given that Increasing age or patients aged more than 75 years were significantly associated with mortality during hospitalization, as the patients' FEV1 declines at a more accelerated rate in older COPD patients than younger ones. 18 Our study showed increased mortality with age (70.04 ± 13.38) with P value of 0.037, similar to the one study where age was independently found to be statistically significant for in-hospital mortality in patients with AECOPD [19].…”

Section: Discussionsupporting

confidence: 86%

“…26,27 One study reported PCO2 as independent predictor of mortality in patients with AECOPD. 19 Gunen et al also showed increased mortality rate in COPD hospitalized patients with higher PCO2. 28 Similar to previous reports our study showed PCO2 was independently found to be statistically significant predictors of in-hospital mortality of AECOPD patients.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Mortality Predictors in Hospitalized Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)

Mankani¹,

Saifullah²,

Akhter³

et al. 2022

J Aziz Fatm Med Den College

View full text Add to dashboard Cite

Objectives: To determine predicting factors for in-hospital outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) Methodology: A prospective cross-sectional validation study was performed in Jinnah Postgraduate Medical Center Karachi, Pakistan from 2019 to 2020 at the Chest Medicine department, a largest public tertiary care center in Karachi. All the patients with other inflammatory diseases such as malignancy, Arthritis, Inflammatory bowel diseases, connective tissue disorders, bronchiectasis (radiologically proven or history of phlegm expectoration >30 ml/day) or history of Tuberculosis were excluded. Patients with a recent history of use of antibiotic treatment or systemic steroids (prednisolone equivalent to >20 mg/day) in the preceding two months on medical record were also excluded from the study. Ethical Approval was taken from Institutional Research committee. All the patients who were presented to ER with Acute exacerbation of COPD was included in the study, AECOPD was defines Anthonisen criteria. Data was entered into SPSS version 21 for statistical analysis of the data. Results: Total 157 study participants were included into the study with predominance of male gender (n=106, 67.5%). The average age of study participants was 65.1 ± 11.41 years. Age was significantly higher among non-survivors than survivors (p=0.037). PH level at 4 hours was significantly lower in survivors (p=0.038). Heart rate (p=0.026) and respiratory rate (p=0.018) were significantly higher among non-survivors at 4 hours. Among NLR, PLR, PCO2, PO2 and HCO3, a higher sensitivity of 92.59% for NLR and lower specificity of 6.15% PCO2 was determined. None of these parameters had area under the curve significantly higher than 0.5. Multivariable logistic regression showed that age and PCO2 were independently predictors of mortality. Conclusion: The present study found that increasing age and PCO2 were significant predictors of mortality in in patients with acute exacerbation of chronic obstructive pulmonary disease. NLR has high sensitivity and low specificity in determining the mortality

show abstract