Predictors of Mortality in Necrotizing Soft Tissue Infections in Adults – Experience at A Tertiary Care Hospital in Pakistan

Abstract

Introduction: Necrotizing soft tissue infection is a potentially fatal ‘flesh-eating’ disease that requires prompt intervention to save a patient’s life. Identification of parameters that indicate worsening of the disease (predictors of mortality) is an important part in management that guides a surgeon towards rapid surgical treatment. Aims & Objectives: This retrospective study aims to identify factors that are associated with mortality in adults with NSTIs. This study also aims to propose solutions for the better management of these infection to improve surgical outcome and survival. Place and duration of study: OPD & Emergency of Surgical Unit I and II of Shaikh Zayed Hospital, Lahore over a period of 10 years between the years 2010 to 2021. Material & Methods: This is a cross-sectional epidemiological, retrospective study conducted on patients presenting in the Outpatients Department, as well as the Emergency of Surgical Unit I and II. A total of 72 patients meeting the inclusion criteria were enrolled in this study. SPSS version 23 was used for data analysis. Results: Out of 72 patients, 31.94% of patients were receiving some form of immunosuppressive treatment (n=23), out of which 7 patients lost their life (30.43%, p=0.000). There was a preexisting immunosuppressive disease in 48.61% patients (n=35), and in this subset, a total of 10 patients didn’t recover (28.57%, p=0.000). 13 out of 17 patients who died received first debridement after 12 hours from presentation (p=0.021). High mortality was seen in patients who had the presence of shock at hospital admission. Conclusion: Delay in diagnosis and surgical treatment, the presence of shock at admission accompanied by evidence of organ dysfunction, increasing comorbidity index are reasons for the higher mortality seen in these patients of NSTIs. The timing of the first surgery is of the essence thus highlighting the importance of the “Golden Hour” for the Management of NSTIs.

Prevalence and Antimicrobial Susceptibility Testing and Analysis of Microbes Isolated from Different Clinical Samples

“…This can be proved by a study conducted in a developed country (i.e., US) in which 2.4 million patients were identified to be infected with skin and soft tissue infections in the year 2000 and a total of 3.3 million patients experienced SSTIs in 2012. A study conducted in an underdeveloped country (i.e., Pakistan) identified 72 patients experiencing necrotizing soft tissue infections in 2021 in a tertiary care hospital 24,25 . A total of 330 samples of pus and 217 samples of tissue were collected, of which 216 pus samples and 104 tissue samples were culture-positive.…”