Predictors of myocardial recovery in pediatric tachycardia-induced cardiomyopathy

Moore, Jeremy P.; Patel, Payal A.; Shannon, Kevin; Albers, E.; Salerno, Jack C.; Stein, Maya; Stephenson, Elizabeth A.; Mohan, Shaun; Shah, Maully J.; Asakai, Hiroko; Pflaumer, Andreas; Czosek, Richard J.; Everitt, Melanie D.; Garnreiter, Jason M.; McCanta, Anthony C.; Papez, Andrew L.; Escudero, Carolina A.; Sanatani, Shubhayan; Cain, Nicole; Kannankeril, Prince J.; Bratincsák, András; Mandapati, Ravi; Silva, Jennifer N. Avari; Knecht, Kenneth R.; Balaji, Seshadri

doi:10.1016/j.hrthm.2014.04.023

Cited by 81 publications

(78 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is a predictable pattern of resolution with treatment and although previous small reports describe weeks to months for functional recovery and years for reverse remodeling, the median time to recovery in a larger study was <2 months (86). Recovery seems independent of treatment strategy (ablation vs. medical therapy).…”

Section: Aic In Childrenmentioning

confidence: 92%

“…In the largest pediatric series of AIC, AET (59%) and permanent junctional reciprocating tachycardia (PJRT; 23%) were the most common arrhythmias represented. Ventricular arrhythmias were uncommon (86). …”

Section: Aic In Childrenmentioning

confidence: 99%

“…Incessant ventricular tachycardia of infancy occurs in association with ventricular Purkinje cell tumors or histiocytoid or lymphocytoid tumors (118–121). Both left and right ventricular tachycardias can result in pediatric AIC (86), and there are reports of PVC-induced AIC in children (122,123). The burden of ectopy needed, or other features associated with AIC risk, have not been defined.…”

Section: Aic In Childrenmentioning

confidence: 99%

See 2 more Smart Citations

Arrhythmia-Induced Cardiomyopathies

Gopinathannair

Etheridge

Marchlinski

et al. 2015

Journal of the American College of Cardiology

307

116

View full text Add to dashboard Cite

Arrhythmia-induced cardiomyopathy (AIC) is a potentially reversible condition in which left ventricular dysfunction is induced or mediated by atrial or ventricular arrhythmias. Cellular and extracellular changes in response to the culprit arrhythmia have been identified, but specific pathophysiological mechanisms remain unclear. Early recognition of AIC and prompt treatment of the culprit arrhythmia using pharmacological or ablative techniques results in symptom resolution and recovery of ventricular function. Although cardiomyopathy in response to an arrhythmia may take months to years to develop, recurrent arrhythmia can result in rapid decline in ventricular function with development of heart failure, suggesting residual ultrastructural abnormalities. Reports of sudden death in patients whose left ventricular ejection fraction have normalized cast doubt on the complete reversibility of this condition. Several aspects of AIC, including specific pathophysiological mechanisms, predisposing factors, optimal therapeutic strategies to prevent ultrastructural changes, and long-term risk of sudden death remain unresolved and need further research.

show abstract

Section: Aic In Childrenmentioning

confidence: 92%

Section: Aic In Childrenmentioning

confidence: 99%

Section: Aic In Childrenmentioning

confidence: 99%

See 1 more Smart Citation

Arrhythmia-Induced Cardiomyopathies

Gopinathannair

Etheridge

Marchlinski

et al. 2015

Journal of the American College of Cardiology

307

116

View full text Add to dashboard Cite

show abstract

“…Tachycardia-mediated ventricular dysfunction should resolve with time after return of sinus rhythm, but over a more prolonged time period than observed in our patient 12 . A diagnosis of Lyme-associated myocarditis should be considered in patients with arrhythmias uncommon for patients with structurally normal hearts, such as JET and fascicular tachycardia.…”

Section: Discussionmentioning

confidence: 62%

Junctional ectopic tachycardia secondary to myocarditis associated with sudden cardiac arrest

Cunningham

Doroshow

Olivieri

et al. 2017

HeartRhythm Case Reports

View full text Add to dashboard Cite

“…However, TIC is reversible after normalization of the heart rate. 2,3 The underlying mechanisms of TIC in children include rapid atrial or ventricular rates, the duration of tachycardia, atrioventricular dyssynchrony, and heart rate irregularity. 2 As the majority of neonates and infants initially experience asymptomatic tachycardia, the heart rate should be carefully monitored by the pediatrician in all regularly scheduled checkups.…”

mentioning

confidence: 99%