Predictors of neurocognitive impairment at 2years after a first-episode major depressive disorder

Gu, Chuanzheng; He, Hui-li; Duan, Hongbo; Su, Zhonghua; Chen, Hong; Gan, Jing-li

doi:10.1016/j.comppsych.2016.03.009

Cited by 23 publications

(13 citation statements)

References 68 publications

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“…Additionally, the clinical characteristics of a recurrent depressive episode, the presence of a comorbid chronic medical disorder, and the SDS scores were not significantly related to cognitive improvement. Our findings agree with those of one previous study 15) that showed no significant relationship between cognitive impairment and demographic characteristics, such as age, gender, or years of education. The strengths of this study include the use of a structured research protocol, well-recognized and standardized scales, and a prospective study design.…”

Section: Discussionsupporting

confidence: 93%

“…A longitudinal study reported that clinical and sociodemographic factors were not associated with cognitive impairment. 15) The same study also suggested that neuro-psychological factors, such as processing speed impairment at baseline, were significant predictors of long-term global neurocognitive functioning. However, few clinical or treatment-related variables were examined, and the study was performed with a limited number of subjects.…”

Section: Introductionmentioning

confidence: 87%

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Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

Lee

Kim

Kang

et al. 2018

Clin Psychopharmacol Neurosci

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Objective: Cognitive disturbance is one of the major symptoms of depression and may be improved by treatment with antidepressants. This study aimed to investigate the predictors of cognitive improvement in patients with major depressive disorder (MDD) who were taking antidepressants. Methods: This study included 86 patients with MDD who completed 12 weeks of antidepressant monotherapy. Cognitive symptoms were assessed using the Perceived Deficits Questionnaire-Korean version (PDQ-K), which addresses four domains of cognitive functioning (attention/concentration, retrospective memory, prospective memory, and organization/ planning) and was administered at study entry and at the 12-week end point. A variety of demographic, clinical, and treatment-related variables were evaluated as predictors of changes in total and domain scores. Results: All PDQ-K domains showed significant improvement after 12 weeks of antidepressant treatment. More severe initial depressive symptoms, fewer sick-leave days at study entry, and reduced use of concomitant anxiolytics/hypnotics during treatment were significantly associated with greater cognitive improvement. Conclusion: Cognitive symptoms are more responsive to antidepressant treatment in patients with severe MDD. Reduced use of anxiolytics and hypnotics could improve the cognitive functioning of patients with MDD taking antidepressants.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 87%

Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

Lee

Kim

Kang

et al. 2018

Clin Psychopharmacol Neurosci

View full text Add to dashboard Cite

show abstract

“… 1 , 2 The opposite is also true, since cognitive impairment is a risk factor for major depressive disorder (MDD). 3 No single cognitive function has been found to characterize all depressed patients; and also, not all patients have impairment to the same cognitive domain or to the same degree. 1 Nonetheless, it has been found in many studies with depressed patients that memory is overvalued and better investigated than other cognitive abilities such as attention, executive functions, and speed of information processing.…”

mentioning

confidence: 99%

Decision Making assessed by the Iowa Gambling Task and Major Depressive Disorder A systematic review

Siqueira

Flaks

Biella

et al. 2018

Dement. neuropsychol.

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Major Depressive Disorder (MDD) can occur in parallel with cognitive impairment. The search for a neuropsychological profile of depression has been pursued in the last two decades. However, scant research has been done on executive functions and decision-making ability (DM).Objective:To perform a systematic review of the evidence of DM performance evaluated using the Iowa Gambling Task (IGT) in adults with MDD.Methods:A systematic search according to the PRISMA statement was performed on MEDLINE for studies in English using the following keywords: ‘depression’, ‘depressive’, ‘depressive symptoms’ AND ‘decision making’ OR ‘game task’.Results:Five articles that met the inclusion and exclusion criteria were identified. Three reported significant differences between depressed and non-depressed individuals. The results indicated that young adults with MDD exhibited lower performance on all or almost all stages of the IGT. One study that evaluated DM in older adults with MDD showed that depressed non-apathetic participants failed to adopt any advantageous strategy and continued to make risky decisions during the task.Conclusion:Results suggest that performance on the DM task by young and old adults with MDD differed in comparison to non-depressed participants. Given the small number of articles, further studies should be performed.

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“…A longitudinal study reported that clinical and socio-demographic factors were not associated with cognitive impairment. 15) The same study also suggested that neuropsychological factors, such as processing speed impairment at baseline, were significant predictors of long-term global neurocognitive functioning. However, few clinical or treatment-related variables were examined, and the study was performed with a limited number of subjects.…”

Section: Introductionmentioning

confidence: 86%

Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

Lee

Kim

Kang

et al. 2018

Clin Psychopharmacol Neurosci

View full text Add to dashboard Cite

ObjectiveCognitive disturbance is one of the major symptoms of depression and may be improved by treatment with antidepressants. This study aimed to investigate the predictors of cognitive improvement in patients with major depressive disorder (MDD) who were taking antidepressants.MethodsThis study included 86 patients with MDD who completed 12 weeks of antidepressant monotherapy. Cognitive symptoms were assessed using the Perceived Deficits Questionnaire-Korean version (PDQ-K), which addresses four domains of cognitive functioning (attention/concentration, retrospective memory, prospective memory, and organization/planning) and was administered at study entry and at the 12-week end point. A variety of demographic, clinical, and treatment-related variables were evaluated as predictors of changes in total and domain scores.ResultsAll PDQ-K domains showed significant improvement after 12 weeks of antidepressant treatment. More severe initial depressive symptoms, fewer sick-leave days at study entry, and reduced use of concomitant anxiolytics/hypnotics during treatment were significantly associated with greater cognitive improvement.ConclusionCognitive symptoms are more responsive to antidepressant treatment in patients with severe MDD. Reduced use of anxiolytics and hypnotics could improve the cognitive functioning of patients with MDD taking antidepressants.

show abstract

Predictors of neurocognitive impairment at 2years after a first-episode major depressive disorder

Cited by 23 publications

References 68 publications

Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

Decision Making assessed by the Iowa Gambling Task and Major Depressive Disorder A systematic review

Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

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