Background. The differences in brain activity between patients with major depressive disorder (MDD) and healthy adults have been confirmed by functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and electroencephalography (EEG), especially at the prefrontal lobe, posterior cingulate cortex (PCC). However, the high cost of fMRI and PET and poor time resolution limited the clinical application. Recently, researchers used high time resolution of standardized weighted low-resolution electromagnetic tomography (swLORETA) to refer to deep brain activity. This study aimed to convert EEG raw signals into swLORETA and explore the differences in deep brain activity between patients with MDD and healthy adults.
Method.BrainMaster equipment with a 19-channel EEG cap was used to collect resting EEG data with eyes closed for 5 min. NeuroGuide software was used to remove the EEG artifacts, and swLORETA software was used to analyze the 12700 voxels of current source density (CSD) for 114 patients with MDD comorbid with anxiety symptoms and 134 healthy adults. The deep brain activity at the frontal lobe and PCC in different frequency bands were analyzed for delta, theta, alpha, and beta.
Results. There were higher activities at prefrontal lobe (dorsal medial prefrontal cortex [dmPFC], ventral medial prefrontal cortex [vmPFC], dorsal lateral prefrontal cortex [dlPFC], ventral lateral prefrontal cortex [vlPFC], orbital frontal cortex [OFC])and PCC were found in MDD patients compared with healthy adults, especially for lower delta and theta, and higher beta, beta3, and high-beta.
Conclusion.This study indicated that brain hyperactivity at the right prefrontal lobe (dlPFC and vmPFC) and PCC in patients with MDD comorbid with anxiety symptoms, and the dlPFC and PCC were also related to emotion-regulation in MDD. Inhibited high-beta activity or rewarded delta and theta activities at the right frontal lobe and PCC may be a possible neurofeedback protocol for patients with MDD in the future study.