Predictors of non-alcoholic fatty liver disease in obese and overweight Egyptian children: Single center study

El‐Karaksy, Hanaa; El-Koofy, Nehal; Anwar, Ghada M.; El-Mougy, Fatma; El-Hennawy, Ahmed; Fahmy, Mona

doi:10.4103/1319-3767.74476

Cited by 15 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, there was an increase in the mean serum level of total cholesterol and triglycerides with increasing the degree of hepatic steatosis. This results was in agreement with Sartorio et al [24], El-Karaksy et al [17] and Duarte and Silva study [26], On the other hand, Papandreo et al [22] reported that none of their studied obese children with NAFLD had abnormal lipid profile or liver indices.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Osteocalcin: A New Biomarker for Non Alcoholic Fatty Liver Disease (NAFLD) in Children and Adolescents

Ebrahim¹,

Elbehery²

2017

Clin Med Biochemistry

View full text Add to dashboard Cite

Background: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease in adults but uncommon in Pediatrics. Patients with chronic liver disease are at increasing risk of developing metabolic bone disease which may be attributed to decreased Osteocalcin which is involved in bone extracellular matrix mineralization. Aim of the work: was to measure serum osteocalcin levels in children and adolescents with NAFLD and to investigate the relationship with variables degrees of NAFLD. Materials and methods: This study was carried out upon 60 children with NAFL detected by abdominal ultrasonography. Forty apparently healthy children, matched for age, sex and body mass index (BMI) were chosen as controls. They were subjected to history taking, clinical examination, investigations included liver function tests, fasting serum glucose and insulin levels, Homeostasis Model Assessment method of Insulin Resistance (HOMA-IR), serum osteocalcin level and abdominal Ultrasonography to assess semiquantitavely the degree of steatosis. Results: Mean serum osteocalcin level was significantly lower in patients than in controls. Mean serum level of ALT, total cholesterol and triglycerides, fasting insulin and HOMA-IR were markedly increases as the hepatic steatosis advancing in severity. There was a parallel decrease of mean serum osteocalcin level with advancing the degree of hepatic steatosis by ultrasound. Serum osteocalcin levels were inversely correlated with the values of W/H ratio, fasting insulin and HOMA-IR. Conclusions: NAFLD had lower serum levels of osteocalcin compared to controls. It were inversely associated with the degrees of steatosis so can considered as a biomarker for severity NAFLD in pediatric age.

show abstract

Section: Discussionsupporting

confidence: 88%

“…Table 2b: Laboratory characteristics of patients and controls (Cont.). An Egyptian study gave the prevalence of NAFLD in 38.5% inobese children and adolescents [17]. Mechanisms behind the reduced BMD in NAFLD are still not completely understood [2].…”

Section: Discussionmentioning

confidence: 99%

Osteocalcin: A New Biomarker for Non Alcoholic Fatty Liver Disease (NAFLD) in Children and Adolescents

Ebrahim¹,

Elbehery²

2017

Clin Med Biochemistry

View full text Add to dashboard Cite

show abstract

“…Similarly, Lin et al ( 16 ) found that the odds ratio of diagnosing NAFLD with USG increased 1.391 times for each 5 cm increase of WC. In a study conducted by el-Karaksy et al ( 40 ), a relationship between BMI, subscapular thickness, hip circumference, and WHR, metabolic parameters, and hepatic steatosis is reported in 2-15 years old children. As in adult studies, a relationship between WC and NAFLD has been shown in childhood ( 30 , 41 ).…”

Section: Discussionmentioning

confidence: 97%

Relationship between Neck Circumference and Non-Alcoholic Fatty Liver Disease in Childhood Obesity

Hatipoğlu

Doğan²,

Mazıcıoğlu³

et al. 2016

Jcrpe

View full text Add to dashboard Cite

Objective:The aim of this study was to establish the association between anthropometric parameters and non-alcoholic fatty liver disease (NAFLD) and to determine the most reliable measurement as a parameter in predicting NAFLD.Methods:Two-hundred fifty-three obese children of ages 10 to 18 years were enrolled in this study. Anthropometric data and metabolic parameters such as fasting blood glucose, insulin and lipid levels, were measured. Liver function tests were assessed. NAFLD was determined by ultrasound.Results:Most metabolic parameters and anthropometric indices were significantly higher in children with NAFLD. A univariate logistic regression analysis was performed, taking NAFLD status as the dependent variable and anthropometric parameters as the independent variables. NAFLD was affected significantly by the anthropometric values. The multiple logistic regression analysis showed that neck circumference (NC) was the only parameter which determined the risk in both genders. Each 1 cm increase in the NC increased the risk of NAFLD 1.544-fold (p<0.001, 95% confidence interval (CI): 1.357-2.214) in the boys and 1.733-fold (p=0.001, 95% CI: 1.185-2.012) in the girls. Receiver operating characteristic analysis was performed to compare the reliability of anthropometric measurements. NC was observed to be a better indicator.Conclusion:Measurement of the NC was shown to be associated with NAFLD in children. We suggest the use of NC as a novel, simple, practical, and reliable anthropometric index in predicting children at risk for NAFLD.

show abstract

“…Additionally, an impressive 83% of children with NASH have a BMI ≥97th percentile for age and sex . Among the obese, hyperinsulinaemia and/or dyslipidaemia are considered to be strong predictors of NAFLD .…”

Section: Non‐alcoholic Fatty Liver Disease Prevalence and Epidemiologymentioning

confidence: 99%

Paediatric non‐alcoholic fatty liver disease: an overview

AlKhater

2015

Obesity Reviews

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is a progressive disease that encompasses a spectrum of liver diseases, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Data related to survival in children are scarce, but these data firmly associate NAFLD with higher risks of hepatic and non-hepatic morbidities and mortalities compared with the general population. More recently, the association between NAFLD and cardiovascular disease among children has increasingly been recognized. Given that obesity is a major risk factor for the disease, paediatric NAFLD is becoming a global issue, paralleling the dramatic rise in obesity worldwide. NASH, which is more common in obese children, has the potential to advance to liver fibrosis and failure. It is unclear why certain patients undergo such transformation but this susceptibility is likely related to an interaction between a genetically susceptible host and the surrounding environment. Currently, treatment is largely conservative and includes lifestyle modification, attainable through healthy weight reduction via diet and exercise. In this review, current knowledge about NAFLD in children is summarized. This review aims to increase the awareness of the medical community about a hidden public health issue and to identify current gaps in the literature while providing directions for future research.

show abstract

Predictors of non-alcoholic fatty liver disease in obese and overweight Egyptian children: Single center study

Cited by 15 publications

References 16 publications

Osteocalcin: A New Biomarker for Non Alcoholic Fatty Liver Disease (NAFLD) in Children and Adolescents

Osteocalcin: A New Biomarker for Non Alcoholic Fatty Liver Disease (NAFLD) in Children and Adolescents

Relationship between Neck Circumference and Non-Alcoholic Fatty Liver Disease in Childhood Obesity

Paediatric non‐alcoholic fatty liver disease: an overview

Contact Info

Product

Resources

About