This study aims to investigate the mediating effect of invasive rumination and career insecurity on relationship between nurses’ job satisfaction and turnover intention. Cross-sectional data were collected from nurses in the Qassim region working in primary healthcare centers and hospitals. Non-probability convenience sampling technique was utilized to obtain 372 participants who completed questionnaire, and SPSS was used to analyze the data. To test the hypotheses, correction and multiple regressions were used. Results revealed that all factors of job satisfaction were significantly related to turnover intention. Also, except for interpersonal relationships, all factors had a significant impact on turnover intention of nurses. Besides, invasive rumination and career insecurity has mediated the relationship amid predictor job satisfaction and criterion turnover intention. Hospitals management must pay attention and support SV nurses to reduce turnover intention. In current crisis, no healthcare organizations afford the turnover intention. For this drive, management must discourage invasive rumination and career insecurity and inspire active rumination, career development, skills, learning environment and perceived organizational support to retain the nurses for longer term.