Predictors of Obstructive Coronary Disease and Mortality in Adults Having Cardiac Arrest

Patel, Jignesh; Thippeswamy, Ganesh; Kataya, Abdo; Loeb, Charles; Parikh, Puja B.

doi:10.1016/j.amjcard.2018.03.023

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…1, the perfusion ξ does not decrease significantly with gradual stenosis in isolated CAD until a critical stenotic value ϕ α is reached, wherein the perfusion collapses relatively. Clinically, the said critical value ϕ α is defined as ≥70% radius α e reduction, significant stenosis [20–22]. However, in patients with comorbid CAD and ventricular hypertrophy, the curve is shifted to the right indicating an increase in the critical stenotic value ϕ α , so that the perfusion ξ of the corresponding supplied myocardial tissue collapses relatively at a clinically subsignificant stenosis.…”

Section: Modelmentioning

confidence: 99%

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Comorbid CAD and ventricular hypertrophy compromise the perfusion of myocardial tissue at subcritical stenosis of epicardial coronaries

Abbas

2019

Egypt Heart J

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BackgroundMost studies of CAD revascularization have been based on and reported according to angiographic criteria which do not consider the relation between the resulting effective flow distal to the stenosis and the demand of a hypertrophied myocardial tissue.ResultsA mathematical model of the myocardial perfusion in comorbid CAD and ventricular hypertrophy, using Poiseuille’s law, indicates that the affected patients are more sensitive to CAD-related hemodynamic changes. They are more prone to develop ischemic complications, mainly non-ST-elevation myocardial infarction (NSTEMI), and arrhythmias than their peers with isolated CAD regarding the same degree of coronary stenosis.ConclusionPatients with comorbid CAD and ventricular hypertrophy suffer from myocardial hypoperfusion at subcritical epicardial stenosis. Accordingly, the comorbidity of both diseases should be considered upon designing of the treatment regimen.

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Section: Modelmentioning

confidence: 99%

“…Significant stenosis has been defined by most studies of CAD revascularization as ≥70% [20] diameter narrowing and/or ≥50% for left main CAD [21, 22]. These criteria have been based on and reported according to an angiographic method.…”

Section: Introductionmentioning

confidence: 99%