Predictors of Out-of-Hospital Cardiac Arrest in Patients Hospitalized With Acute Coronary Syndrome: A Systematic Review and Meta-Analysis

Abstract

Out-of-hospital cardiac arrest (OHCA) refers to the abrupt stoppage of the heart's mechanical activity, primarily triggered by coronary artery disease. OHCA represents a significant global cause of death. The aim of this study was to assess the predictors of OHCA in patients admitted with acute coronary syndrome (ACS). This meta-analysis was conducted following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Two investigators performed a comprehensive search of online databases, including PubMed, EMBASE, and Web of Science, from their inception to October 15, 2023. Keywords such as "predictors," "out-of-hospital cardiac arrest," and "acute coronary syndrome" were used to identify relevant articles. To enhance the search, synonyms and their corresponding Medical Subject Heading terms were included. A total of six studies were included in this meta-analysis. The pooled incidence of out-of-hospital cardiac arrest was 4% (95% confidence interval, 3%-5%). The current meta-analysis reports that age, gender, having multivessel disease, hypertension, dyslipidemia, and having ST-elevation myocardial infarction were some of the significant factors associated with OHCA in patients hospitalized with ACS.