“…As a real-world registry, the study is inherently limited by a lack of valid control groups using historical controls. However, one should also recognize that many of the DES randomized trials performed for device approval have restricted enrollment criteria, making extrapolation of their findings to the greater population questionable (13). The absence of a systematic late (Ͼ12 months) control coronary angiography did not allow a real estimation of the late catch-up phenomenon with DES in ISR lesions, which, however, seems to be clinically irrelevant.…”