Predictors of Outcome in an Open Label, Therapeutic Trial of High-Dose Omeprazole in Laryngitis

Williams, Rohan B. H.; Szczesniak, Michal; Maclean, Julia; Brake, Helen; Cole, Ian; Cook, Ian J.

doi:10.1111/j.1572-0241.2004.04151.x

Cited by 89 publications

(95 citation statements)

References 29 publications

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“…Reflü içeriğinin hipofarenkse ulaşması ile salınan sitokinler mukozada enflamasyon, ödem, eritem ile larengeal belirtilere ve hırıltıya yol açtığı, ayrıca nazofarengeyal enflamasyonun östaki tüpünde obstruksiyona yol açarak otit sıklığını artırdığı öne sürülmüştür (11)(12)(13).…”

Section: Rġsk Faktörlerġ Ve Patofġzyolojġunclassified

Çocuklarda Gastroözofagiyal Reflü Hastalığı

Kırşaçlıoğlu¹,

Köksal²

2015

J Contemp Med

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Section: Rġsk Faktörlerġ Ve Patofġzyolojġunclassified

Çocuklarda Gastroözofagiyal Reflü Hastalığı

Kırşaçlıoğlu¹,

Köksal²

2015

J Contemp Med

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“…Proximal oesophageal and hypopharyngeal pH testing are not widely available and are considered less useful by both community and academic gastroenterologists (Ahmed et al 2006), and there is a lack of consensus on how much refl ux in the hypopharynx is normal. Most studies show that hypopharyngeal pH-monitoring is not a predictor of response to acid inhibitory therapy as response to therapy is no more likely in individuals with abnormal hypopharyngeal acid refl ux compared to individuals with no acid refl ux (El-Serag et al 2001;Noordzij et al 2001;Vaezi et al 2003;Williams et al 2004;Vaezi et al 2006;Wo et al 2006). Finally it should be taken into account that oesophageal pH-monitoring is not even a perfect gold standard test for GERD.…”

Section: Reimer and Bytzermentioning

confidence: 99%

“…Various modifi cations of the Laryngeal Symptom Score (LSS) have been used in some studies (Williams et al 2004;Wo et al 2006;Qua et al 2007). The frequency and severity of a number (usually up to 6) of LPR symptoms are assessed over the preceding week to give a cumulative score.…”

Section: Patient Reported Outcomes In Laryngopharyngeal Refl Uxmentioning

confidence: 99%

Management of laryngopharyngeal reflux with proton pump inhibitors

Reimer

Bytzer²

2008

TCRM

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Abstract:There is a lack of consistent guidelines and consensus for the diagnosis of laryngopharyngeal refl ux (LPR). A therapeutic trial with a proton pump inhibitor (PPI) has been suggested to identify patients with LPR. This review focuses on the current diffi culties in diagnosing the disease and examines the evidence for the effectiveness of PPI therapy in suspected refl ux-related laryngeal symptoms. Additionally, mode of action, safety, and tolerability of PPIs are described. A total of 7 placebo-controlled trials were identifi ed and included in the review. All studies evaluated the effect of a PPI on symptoms and objective laryngoscopic fi ndings in suspected LPR. Data from these trials show that PPI therapy is no more effective than placebo in producing symptom relief in patients suspected of LPR. Symptoms, laryngoscopic fi ndings, or abnormal fi ndings on pH monitoring will not predict response to PPI therapy. High placebo response levels suggest a much more complex and multifactorial pathophysiology of LPR than simple acid refl ux. Further studies are needed to characterize subgroups of patients with refl ux-associated laryngeal symptoms that might benefi t from treatment with PPI. Future studies should use validated patient reported outcome measures with endpoints that represent a predefi ned clinically meaningful change in symptom scores.

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“…Chronic cough, hoarseness, sinusitis, chronic otitis media, erythema in the larynx, a cobblestone appearance, reaching of the reflux content to hypopharynx, the release of cytokines and associated with this laryngeal symptoms, such as mucosal inflammation, edema, erythema, and stridor appear. Moreover, it is suggested that nasopharyngeal inflammation leads to an increase in otitis media by causing obstruction in the Eustachian tube (16)(17)(18).…”

Section: Clinical Featuresmentioning

confidence: 99%

From Newborn to Teenage: Gastroesophageal Reflux

Urgancı¹,

Usta²

2016

JAREM

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Gastroesophageal reflux (GER) is characterized by the involuntary passage of gastric contents into the esophagus. GER disease is defined as a persistent or intermittent passage of gastric contents into the esophagus, which often results in overt clinical signs and symptoms and affects the quality of life. GER is a common disorder in childhood and has a good prognosis. GER in infancy begins within the first month of life, peaks at the 4 th month, and after the first year, it steadily decreases and finally resolves at the age of 2 years. GER physiologically occurs due to the relaxation of the lower esophageal sphincter, independent of swallowing. The mechanisms against GER include the following; 1. Lower esophageal sphincter dysfunction, 2. Clearance effect of esophagus, 3. Esophageal mucosal integrity, and 4. Gastric emptying, which prevent the development of GER disease. Although the physiopathology of GER is still not clearly established, proposed factors are genetic, environmental, anatomic, hormonal, and neurogenic. The most responsible factor is lower esophageal sphincter relaxations. The clinical signs of GER varies with age but commonly appear with gastrointestinal and respiratory symptoms. The diagnosis of GER disease is based on history, physical examination, esophageal pH monitoring, multichannel intraluminal impedance and esophageal manometry, motility examinations, endoscopy, biopsy, examinations with barium, and nuclear scintigraphy. Treatment of GER includes non-pharmacological and pharmacological therapies, such as prokinetic agents and acid suppressors. Surgical treatment indications are relatively limited. (JAREM 2016; 6: 67-73)

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Predictors of Outcome in an Open Label, Therapeutic Trial of High-Dose Omeprazole in Laryngitis

Cited by 89 publications

References 29 publications

Çocuklarda Gastroözofagiyal Reflü Hastalığı

Çocuklarda Gastroözofagiyal Reflü Hastalığı

Management of laryngopharyngeal reflux with proton pump inhibitors

From Newborn to Teenage: Gastroesophageal Reflux

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