To prevent side branch occlusion during bifurcational lesion stenting, the placement of a wire in both the main branch and side branch is performed for "side-branch protection". However, this procedure does not always prevent side branch occlusion. A procedure for placing two wires in the side branch, called "two-wire protection of side branches", is considered to be more likely to prevent occlusion compared with one-wire protection of the side branch. We report on three cases in which "two-wire protection of side branches" was effectively performed during the stenting of bifurcational lesions.