Predictors of Persistence of Use of the Novel Antidiabetic Agent Acarbose

Catalan, Vanessa S; Couture, Jocelyne; LeLorier, Jacques

doi:10.1001/archinte.161.8.1106

Cited by 39 publications

(26 citation statements)

References 12 publications

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“…RESULTS -The systematic review was based on 20 reports that included quantitative information on adherence or persistence with diabetes medications (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). The few studies that included laboratory data all showed HbA 1c levels Ͼ7%.…”

Section: Adherence Assessmentmentioning

confidence: 99%

A Systematic Review of Adherence With Medications for Diabetes

2004

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OBJECTIVE -The purpose of this study was to determine the extent to which patients omit doses of medications prescribed for diabetes. -A literature search (1966 -2003) was performed to identify reports with quantitative data on adherence with oral hypoglycemic agents (OHAs) and insulin and correlations between adherence rates and glycemic control. Adequate documentation of adherence was found in 15 retrospective studies of OHA prescription refill rates, 5 prospective electronic monitoring OHA studies, and 3 retrospective insulin studies. RESEARCH DESIGN AND METHODSRESULTS -Retrospective analyses showed that adherence to OHA therapy ranged from 36 to 93% in patients remaining on treatment for 6 -24 months. Prospective electronic monitoring studies documented that patients took 67-85% of OHA doses as prescribed. Electronic monitoring identified poor compliers for interventions that improved adherence (61-79%; P Ͻ 0.05). Young patients filled prescriptions for one-third of prescribed insulin doses. Insulin adherence among patients with type 2 diabetes was 62-64%.CONCLUSIONS -This review confirms that many patients for whom diabetes medication was prescribed were poor compliers with treatment, including both OHAs and insulin. However, electronic monitoring systems were useful in improving adherence for individual patients. Similar electronic monitoring systems for insulin administration could help healthcare providers determine patients needing additional support.

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Section: Adherence Assessmentmentioning

confidence: 99%

A Systematic Review of Adherence With Medications for Diabetes

2004

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“…This database has been validated 13,14 and has been used in other studies. [15][16][17][18] From the medical services database we obtained data on physician visits; International Classification of Diseases (ninth revision, clinical modification [ICD-9-CM]) diagnosis codes; procedures performed; 19 the date of each visit; and information about the site of service. We obtained patient sex, date of birth, type of coverage and the date of death for deceased patients from the demographics database.…”

Section: Data Sourcesmentioning

confidence: 99%

Restrictive access to clopidogrel and mortality following coronary stent implantation

Sheehy¹,

LeLorier²,

Rinfret³

2008

Canadian Medical Association Journal

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“…Other commonly used maximum allowed treatment gaps are 30 days (comparable to 0.33 times the theoretic duration), 45 days (comparable to 0.5 times the theoretic duration), 90 days which is comparable to one times the theoretic duration of a prescription and 180 days, which is comparable to two times the theoretic duration of a prescription. [7][8][9][10][11][12][13][14][15]. Furthermore, we choose to study the extremes of three and four times the theoretic duration of a prescription (method 2) as well as 270 and 360 days (method 1).…”

Section: Definitionsmentioning

confidence: 99%

“…In the literature, different approaches are used to define persistence with drug use. A comparison of results of refill persistence studies is therefore complicated due to the variation of the methods [7][8][9][10][11][12][13][14][15]. The aim of our study was to compare three different methods of calculating a 1-year refill persistence rate and associations between patient characteristics and 1-year persistence.…”

Section: Introductionmentioning

confidence: 99%

Refill persistence with chronic medication assessed from a pharmacy database was influenced by method of calculation

Wijk¹,

Klungel²,

Heerdink³

et al. 2006

Journal of Clinical Epidemiology

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Background and Objectives: In literature, different methods of calculating persistence are used. In this study, the effect of using these different methods on persistence and the association of patients characteristics and persistence are assessed.Methods: The PHARMO record linkage system was used to calculate persistence with antihypertensive drugs for a cohort of 14,466 new users of antihypertensives. Three different types of methods were used to define the maximum gap allowed between two prescriptions that a patient may have to be defined as a continuous user, one based on a defined number of days (varying from 9-365 days), the second based on the duration of the last prescription (varying from 0.1-4 times the duration), the third based on a combination of both methods, whichever leads to the lowest number of days.Results: Refill persistence varied between 19.7-86.4% (method 1), between 27.9-90.2% (method 2), and between 19.7-86.4% (method 3). Furthermore, patient characteristics associated with persistence differed between and within the three different methods.Conclusion: The method used and the variation within a method influenced both persistence and the association between patient characteristics and persistence. Results of persistence studies are highly influenced by the researchers' method of the maximum allowed treatment gap. Ó

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Predictors of Persistence of Use of the Novel Antidiabetic Agent Acarbose

Cited by 39 publications

References 12 publications

A Systematic Review of Adherence With Medications for Diabetes

A Systematic Review of Adherence With Medications for Diabetes

Restrictive access to clopidogrel and mortality following coronary stent implantation

Refill persistence with chronic medication assessed from a pharmacy database was influenced by method of calculation

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