Predictors of persistent symptoms after severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among healthcare workers: Results of a multisite survey

Pop-Vicas, Aurora; Osman, Fauzia; Tsaras, Geoffrey; Seigworth, Claire; Muñoz-Price, L. Silvia; Safdar, Nasia

doi:10.1017/ice.2022.56

Cited by 3 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of studies showed the association of the severity of the acute COVID-19 with the occurrence of long-term neurological consequences [ 23 , 39 , 42 , 46 , 48 , 49 , 50 ]. It was also found that the number of initial symptoms better predicts the presence of long COVID than the severity of the acute phase of the disease [ 47 , 50 , 56 ]. Other studies showed that severity of the acute phase of the disease is less important as predictor of the long-term health complications than cumulative number of the specific COVID-19 symptoms, so-called number of initial symptoms, during the first week of acute phase [ 47 , 50 , 56 ].…”

Section: Predictors Of Post-covid Neurological Complicationsmentioning

confidence: 99%

“…It was also found that the number of initial symptoms better predicts the presence of long COVID than the severity of the acute phase of the disease [ 47 , 50 , 56 ]. Other studies showed that severity of the acute phase of the disease is less important as predictor of the long-term health complications than cumulative number of the specific COVID-19 symptoms, so-called number of initial symptoms, during the first week of acute phase [ 47 , 50 , 56 ]. Miskowiak et al [ 23 ] studied the relationship between acute phase severity and cognitive changes in post-COVID patients.…”

Section: Predictors Of Post-covid Neurological Complicationsmentioning

confidence: 99%

See 1 more Smart Citation

Role of Demyelination in the Persistence of Neurological and Mental Impairments after COVID-19

Khodanovich

Parshukova

Naumova

2022

IJMS

View full text Add to dashboard Cite

Long-term neurological and mental complications of COVID-19, the so-called post-COVID syndrome or long COVID, affect the quality of life. The most persistent manifestations of long COVID include fatigue, anosmia/hyposmia, insomnia, depression/anxiety, and memory/attention deficits. The physiological basis of neurological and psychiatric disorders is still poorly understood. This review summarizes the current knowledge of neurological sequelae in post-COVID patients and discusses brain demyelination as a possible mechanism of these complications with a focus on neuroimaging findings. Numerous reviews, experimental and theoretical studies consider brain demyelination as one of the mechanisms of the central neural system impairment. Several factors might cause demyelination, such as inflammation, direct effect of the virus on oligodendrocytes, and cerebrovascular disorders, inducing myelin damage. There is a contradiction between the solid fundamental basis underlying demyelination as the mechanism of the neurological injuries and relatively little published clinical evidence related to demyelination in COVID-19 patients. The reason for this probably lies in the fact that most clinical studies used conventional MRI techniques, which can detect only large, clearly visible demyelinating lesions. A very limited number of studies use specific methods for myelin quantification detected changes in the white matter tracts 3 and 10 months after the acute phase of COVID-19. Future research applying quantitative MRI assessment of myelin in combination with neurological and psychological studies will help in understanding the mechanisms of post-COVID complications associated with demyelination.

show abstract

Section: Predictors Of Post-covid Neurological Complicationsmentioning

confidence: 99%

Section: Predictors Of Post-covid Neurological Complicationsmentioning

confidence: 99%

Role of Demyelination in the Persistence of Neurological and Mental Impairments after COVID-19

Khodanovich

Parshukova

Naumova

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…We and others have found significant dose-response relationships between the intensity of COVID-19 related occupational stressors experienced and negative psychiatric and occupational outcomes in healthcare workers, supporting a causal role of stressful and demoralizing experiences for healthcare workers working during the pandemic on psychiatric and occupational outcomes 1,4 . Alternatively, acute infection with COVID-19 has itself been found to be associated with persistent increases in psychiatric distress and worsened functional outcomes in a wide variety of populations 5 , including healthcare workers 6 . As high rates of exposure to COVID-19 related occupational stressors and elevated risk of COVID-19 infection have often gone hand in hand for healthcare workers, it has been challenging to assess the relative contributions of COVID-19 infection and occupational stress and trauma for healthcare worker health and occupational outcomes.…”

Section: Introductionmentioning

confidence: 99%

The relative contribution of COVID-19 infection versus COVID-19 related occupational stressors to insomnia in healthcare workers

Hendrickson

McCall

Rosser

et al. 2022

Preprint

View full text Add to dashboard Cite

Objective/Background: Healthcare workers have experienced high rates of psychiatric symptom burden and occupational attrition during the COVID-19 pandemic. Identifying contributory factors can inform prevention and mitigation measures. Here, we explore the potential contributions of occupational stressors vs COVID-19 infection to insomnia symptoms in US healthcare workers. Patients/Methods: An online self-report survey was collected between September 2020 and July 2022 from N=594 US healthcare workers, with longitudinal follow-up up to 9 months. Assessments included the Insomnia Severity Index (ISI), the PTSD Checklist for DSM-5 (PCL-5), and a 13-item scale assessing COVID-19 related occupational stressors. Results: Insomnia was common (45% of participants reported at least moderate and 9.2% reported severe symptoms at one or more timepoint) and significantly associated with difficulty completing work-related tasks, increased likelihood of occupational attrition, and thoughts of suicide or self-harm (all p<.0001). In multivariable regression with age, gender, and family COVID-19 history as covariates, past two-week COVID-related occupational stressors, peak COVID-related occupational stressors, and personal history of COVID-19 infection were all significantly related to past two-week ISI scores (Beta=1.7+/-0.14SE, Beta=0.08+/-0.03, and Beta=0.69+/-0.22 respectively). Although similar results were found for the PCL-5, when ISI and PCL-5 items were separated by factor, COVID-19 infection was significantly related only to the factor consisting of sleep-related items. Conclusions: Both recent occupational stress and personal history of COVID-19 infection were significantly associated with insomnia in healthcare workers. These results suggest that both addressing occupational stressors and reducing rate of COVID-19 infection are important to protect healthcare workers and the healthcare workforce.

show abstract

The relative contribution of COVID-19 infection versus COVID-19 related occupational stressors to insomnia in healthcare workers

et al. 2023

View full text Add to dashboard Cite

Predictors of persistent symptoms after severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among healthcare workers: Results of a multisite survey

Cited by 3 publications

References 11 publications

Role of Demyelination in the Persistence of Neurological and Mental Impairments after COVID-19

Role of Demyelination in the Persistence of Neurological and Mental Impairments after COVID-19

The relative contribution of COVID-19 infection versus COVID-19 related occupational stressors to insomnia in healthcare workers

The relative contribution of COVID-19 infection versus COVID-19 related occupational stressors to insomnia in healthcare workers

Contact Info

Product

Resources

About