Predictors of Persistent Symptoms After Mrna Sars-Cov-2 Vaccine-Related Myocarditis (Myovacc Registry)

mRNA-LNP COVID-19 vaccine lipids induce low level complement activation and production of proinflammatory cytokines: Mechanisms, effects of complement inhibitors, and relevance to adverse reactions

“…anaphylatoxin/cytokine double hit) and start of symptoms can be reconciled. Examples for acute, subacute and chronic SAEs include the HSRs or anaphylaxis within minutes to hours [16][17][18][19] , heart inflammation [8][9][10][11][12][13][14][15] , coagulation disorders [21][22][23][24] , or skin diseases [25][26][27][28] can occur within days to months, and autoimmune phenomena 20 may arise without currently foreseeable time limit. A hypothesis that may explain these different latency periods postulates that the actions of effector immune cells, including the mast cells, basophil and neutrophil granulocytes, lymphocytes, macrophages and platelets, are discontinuous, graded in the sense that they manifest only after the activation state of their intracellular inflammatory signaling network reaches the reaction threshold.…”

“…Table 1 lists the vaccine's reported AEs categorized according to the affected organ systems. Of note, myocarditis/pericarditis [8][9][10][11][12][13][14][15] , HSRs/anaphylaxis [16][17][18][19] , autoimmune diseases 20 , thrombosis, thrombocytopenia and other coagulation disorders [21][22][23][24] skin [25][26][27][28] and ocular inflammations [29][30][31] , Guillain-Barre syndrome [32][33][34][35][36][37][38] and other neurologic problems 39,40 can all be linked to acute or subacute inflammatory processes that are also characteristic of SARS-CoV-2 infections.…”