Predictors of Poor Prognosis in Recurrent Hepatitis C After Liver Transplantation

Berge, E.; Oton, E.; Reina, Z.; Díaz, L Díaz; Márquez, Ángel Guerra; Cejas, L.; Acosta, S.; Pérez, Fernando Guerrero

doi:10.1016/j.transproceed.2016.07.043

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Patients with detectable HCV RNA at time of transplantation are at high risk for HCV recurrence, and almost 100 % of liver transplant recipients develop reinfection. HCV recurrence in liver transplant recipients often shows a more aggressive disease course, resulting in graft cirrhosis in fewer than 5 years [23,24]. However, it needs to be emphasized that our data was collected before the era of direct-acting antivirals.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for allograft failure in liver transplant recipients

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Risk factors for allograft failure in liver transplant recipients

et al. 2018

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“…In the current study, recurrent HCV infection was a risk factor for chronic graft rejection, graft failure and mortality. This is predictable due to the aggressive course of HCV recurrence in LT recipients through direct cytotoxic effects on the graft, resulting in graft failure[ 48 , 49 , 51 - 53 ]. It is noteworthy that DAA were not FDA approved during the first three years of the study duration; thus, many patients were ineligible for the Peg-IFN/RBV regimen at that time.…”

Section: Discussionmentioning

confidence: 99%

Biliary complications in recipients of living donor liver transplantation: A single-centre study

Guirguis¹,

Nashaat²,

Yassin³

et al. 2021

WJH

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BACKGROUND Biliary complications (BCs) after liver transplantation (LT) remain a considerable cause of morbidity, mortality, increased cost, and graft loss. AIM To investigate the impact of BCs on chronic graft rejection, graft failure and mortality. METHODS From 2011 to 2016, 215 adult recipients underwent right-lobe living-donor liver transplantation (RT-LDLT) at our centre. We excluded 46 recipients who met the exclusion criteria, and 169 recipients were included in the final analysis. Donors’ and recipients’ demographic data, clinical data, operative details and postoperative course information were collected. We also reviewed the management and outcomes of BCs. Recipients were followed for at least 12 mo post-LT until December 2017 or graft or patient loss. RESULTS The overall incidence rate of BCs including biliary leakage, biliary infection and biliary stricture was 57.4%. Twenty-seven (16%) patients experienced chronic graft rejection. Graft failure developed in 20 (11.8%) patients. A total of 28 (16.6%) deaths occurred during follow-up. BCs were a risk factor for the occurrence of chronic graft rejection and failure; however, mortality was determined by recurrent hepatitis C virus infection. CONCLUSION Biliary complications after RT-LDLT represent an independent risk factor for chronic graft rejection and graft failure; nonetheless, effective management of these complications can improve patient and graft survival.

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Predictors of Poor Prognosis in Recurrent Hepatitis C After Liver Transplantation

Cited by 2 publications

References 14 publications

Risk factors for allograft failure in liver transplant recipients

Risk factors for allograft failure in liver transplant recipients

Biliary complications in recipients of living donor liver transplantation: A single-centre study

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