Predictors of post-COVID symptoms in Egyptian patients: Drugs used in COVID-19 treatment are incriminated

Abdelhafiz, Ahmed Samir; Ali, Asmaa; Maaly, Ayman Mohamed; Mahgoub, Mohamed Anwar; Ziady, Hany H.; Sultan, Eman A.

doi:10.1371/journal.pone.0266175

Cited by 22 publications

(21 citation statements)

References 45 publications

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“…Our findings were the opposite from those reported by Peghin et al ( 18 ), who found no association between age and PCS symptoms after COVID-19. A previous study performed in the Middle East has pointed to female gender as a risk factor for PCS ( 19 ), suggesting a possible relation with Arabic culture, as females are used to take care of family members when they are infected. On the other hand, a relatively significant increase in PCS symptoms among females in UK suggests a possible biological relationship ( 20 ).…”

Section: Discussionmentioning

confidence: 98%

Post-COVID-19 syndrome symptoms after mild and moderate SARS-CoV-2 infection

et al. 2022

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BackgroundPost-COVID-19 Syndrome (PCS) is characterized by residual symptoms following the initial recovery from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The prevalence of PCS is known to be the highest among severe and critical forms of the disease. However, the occurrence and risk factors for PCS after mild or moderate SARS-CoV-2 infection has not been extensively investigated.MethodsOnline and offline via both paper or mailed questionnaires distributed among Jordan collected between 1st and 21st August 2021, including a total number of 800 respondents, of whom 495 had previous mild to moderate COVID-19 infection. The Newcastle post-COVID syndrome Follow-up Screening Questionnaire was modified, translated, and used as a standard instrument for data collection regarding psychological, medical, and socio-economic symptoms post-infection. The primary outcome was the prevalence of PCS after mild to moderate COVID-19 in Jordan. Secondary outcome was the identification of PCS risk factors.ResultsThe most common PCS symptom was mood disturbance followed by fatigue, anxiety, and myalgia. Female gender significantly increased the risk for multiple PCS symptoms. Age < 30 years was found to be an independent risk factor for myalgia (p = 0.001).ConclusionPCS is highly prevalent among COVID-19 survivors in Jordan, especially in females and patients with comorbidities. Planning physical and mental rehabilitation services is recommended for those patients with PCS symptoms after mild to moderate COVID-19 infection.

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Section: Discussionmentioning

confidence: 98%

Post-COVID-19 syndrome symptoms after mild and moderate SARS-CoV-2 infection

et al. 2022

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“…The probability of post covid syndrome symptoms, antiviral and anticoagulant therapy was significantly associated with persistence of COVID-19 symptoms. This is expected as these drugs are prescribed for severe and critical cases (26) .…”

Section: Resultsmentioning

confidence: 96%

Predictors of Post Covid Syndrome among Covid Survivors Patients attending Post Covid Out-Patients Clinic

Elgazzar¹,

El-Shabrawy²,

Kot³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic remains a constant challenge for healthcare systems and affects the well-being of many individuals. The objective of the current study is to determine the parameters that can predict post COVID-19 sequale and incidence of post Covid sequale among Covid survivor's patients attending post covid outpatient clinic. Patients and methods: This was a case control study carried out on 60 COVID-19 survivors whom were recovered from the acute illness and discharged for follow-up at the post covid out-patient clinic at Zagazig University. The sixty patients included in the study were divided to Group I: (Asymptomatic patients): include 30 patients whom were discharged for follow-up and in whom no significant symptoms or signs were reported during the study. Group II: (Symptomatic patients): include 30 patients whom were discharged for follow-up and in whom there were significant symptoms or signs during the study. Results: There is statistically significantly association between initial parameters high (CRP, D-dimer, ferritin, LDH, IL6) and low Lymphocytes. Post covid degree of lung affection in chest CT scan where Grade ≥5 (severe lung affection) prevailed in 63.3% and 20% in those with and without post covid syndrome, respectively, while Grade <2 (less sever lung affection) was more dominant in those without post covid (30% vs. 6.7%). Conclusion: Persistence of symptoms is common after the acute phase of COVID-19 infection. Post covid syndrome occurs regardless of the disease severity. High CRP, LDH, ferritn, D-dimer, and IL6, low Lymphocytes and degree of lung affection at diagnosis of acute covid19 may be good predictors for the occurrence of post covid syndrome.

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“…We found that severity of index COVID-19 illness (SOFA scores or intubation) was a predictor of limited activities of daily living and post-acute COVID-19 symptoms. Indeed, many others have identified index COVID-19 severity as a predictor of protracted COVID symptoms [ 28 , 36 , 37 , [47] , [48] , [49] , [50] ]. Some studies have suggested that the severity of acute respiratory failure, rather than the pathogen involved, predicts neuropsychiatric sequelae.…”

Section: Discussionmentioning

confidence: 99%