Predictors of pressure ulcer incidence following traumatic spinal cord injury: a secondary analysis of a prospective longitudinal study

Brienza, David M.; Krishnan, Shilpa; Karg, Patricia; Sowa, Gwendolyn; Allegretti, Ana

doi:10.1038/sc.2017.96

Cited by 67 publications

(56 citation statements)

References 43 publications

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“…Os estudos selecionados para esta revisão integrativa da literatura foram publicados em inglês e realizados nos seguintes países: um nos Países Baixos (15) , três nos Estados Unidos da América (EUA) (16)(17)(18) , um no Japão (19) e um na França (20) . O tamanho da amostra dos estudos variou entre 61 e 4.866 indivíduos adultos, predominantemente do sexo masculino e com lesão medular de etiologia traumática.…”

Section: Resultsunclassified

“…ção neurológica (15)(16)(17)(18) e dois estudos (19)(20) analisaram o risco após a reabilitação neurológica.…”

Section: Resultsunclassified

“…Os estudos que avaliaram o risco de lesão por pressão durante a reabilitação neurológica, foram estudos observacionais de coorte (15)(16)(17)(18) . Dentre os estudos, dois verificaram fatores de risco para lesão por pressão, durante a reabilitação neurológica (15)(16) , e outros dois analisaram o risco de lesão por pressão durante a fase aguda da lesão medular e durante a reabilitação neurológica; os fatores de risco encontrados nos estudos foram semelhantes para as duas etapas (17)(18) .…”

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Pressure ulcers in individuals with spinal cord injury: risk factors in neurological rehabilitation

Silva

Rodrigues

2020

Rev Rene

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Objective: to identify risk factors for the occurrence of pressure ulcers in adult individuals with spinal cord injuries in neurological rehabilitation. Methods: integrative review of studies published in the bases Medical Literature Analysis and Retrieval System Online, Cumulative Index to Nursing and Allied Health Literature and Latin American and Caribbean Literature in Health Sciences. Results: 308 studies were found, with six articles selected, based on pre-established inclusion criteria. The number of risk factors found was similar during and after neurological rehabilitation. Conclusion: the risk factors found for the occurrence of pressure ulcers during and after neurological rehabilitation, were related to sociodemographic conditions, the spinal cord injury itself, associated with clinical condition and behavior. With the exception of complete injury and a history of pressure ulcers, risk factors varied during and after rehabilitation stages.

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Section: Resultsunclassified

“…ção neurológica (15)(16)(17)(18) e dois estudos (19)(20) analisaram o risco após a reabilitação neurológica.…”

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Pressure ulcers in individuals with spinal cord injury: risk factors in neurological rehabilitation

Silva

Rodrigues

2020

Rev Rene

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“…A total of 24 studies with 600,078 study participants were included to estimate the pooled prevalence of PU among SCI patients. In this meta-analysis, various countries were represented across a globe: 8 of studies were from America [6,[38][39][40][41][42][43], 7 from Europe [18,23,[44][45][46][47][48], 5 from Asia [20,28,[49][50][51], and 4 from Africa [7,22,24,52]. The highest prevalence of PU (56%) was reported from Europe [44], whereas the lowest prevalence (11%) was reported in a study conducted in America [6].…”

Section: Baseline Characteristic Of the Included Studiesmentioning

confidence: 99%

The global burden of pressure ulcers among patients with spinal cord injury: a systematic review and meta-analysis

Shiferaw

Akalu

Mulugeta

et al. 2020

BMC Musculoskelet Disord

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Background: Pressure ulcers (PU), one of the common challenging public health problems affecting patient with spinal cord injury. PUs occurs over bony areas of the body where pressure and tissue distortion is greatest. It has a significant impact to the patient and health care system. Moreover, it has psychological, physical, social burden and decrease the quality of life (QoL) of patients. Despite its serious complications, limited evidence is available on the global magnitude of pressure ulcers among patient with spinal cord injury. Hence, this review and meta-analysis aimed to estimate the global magnitude of pressure ulcers among patient with spinal cord injury. Methods: PubMed, Scopus, Google Scholar, African Journals Online, PsycINFO, and Web of Science were systematically searched to retrieve related articles. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guideline was followed. DerSimonian and Laird random-effects model was applied to obtain the pooled effect size. To investigate heterogeneity across the included studies, I 2 test was employed. Publication bias was examined using funnel plot and Egger's regression test statistic. Sensitivity analysis was deployed to see the effect of a single study on the overall estimation. Analysis was done using STATA™ Version 14 software. Results: A total of 24 studies which comprises of 600,078 participants were included in this study. The global pooled magnitude of pressure ulcers among patients with spinal cord injury was 32.36% (95% CI (28.21, 36.51%)). Based on the subgroup analysis, the highest magnitude of pressure ulcer was observed in Africa 41.19% (95% CI: 31.70, 52.18). Conclusion: This systematic review and meta-analysis revealed that about one in three patients with spinal cord injury had pressure ulcers. This implies that the overall global magnitude of pressure ulcer is relatively high. Therefore, policy maker and other concerned body should be design country context-specific preventive strategies to reduce the burden of pressure ulcers in patients with spinal cord injury.

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“…Spinal cord injury (SCI) refers to the damage to the spinal cord due to trauma, disease or degeneration (Cheshire et al, 1996;Brienza et al, 2018). According to the National Spinal Cord Injury Statistical Center, there are about 12,000 new cases of SCI each year in the United States (Natinal Spinal Cord Injury Statistical Center [NSCISC], 2014).…”

Section: Introductionmentioning

confidence: 99%

The Integrated Transcriptome Bioinformatics Analysis Identifies Key Genes and Cellular Components for Spinal Cord Injury-Related Neuropathic Pain

Huang

Meng

Zhu

et al. 2020

Front. Bioeng. Biotechnol.

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Background: Spinal cord injury (SCI) is one of the most devastating diseases with a high incidence rate around the world. SCI-related neuropathic pain (NeP) is a common complication, whereas its pathomechanism is still unclear. The purpose of this study is to identify key genes and cellular components for SCI-related NeP by an integrated transcriptome bioinformatics analysis. Methods: The gene expression profile of 25 peripheral blood samples from chronic phase SCI patients (E-GEOD-69901) and 337 normal peripheral blood samples were downloaded from ArrayExpress and Genotype-Tissue Expression Portal (GTEx), respectively. A total of 3,368 normal peripheral blood mononuclear cells (PBMC) were download from Sequence Read Archive (SRA713577). Non-parametric tests were used to evaluate the association between all of differential expression genes (DEGs) and SCI-related NeP. CellPhoneDB algorithm was performed to identify the ligand-receptor interactions and their cellular localization among single PBMCs. Transcription factor (TF) enrichment analysis and Gene Set Variation Analysis (GSVA) were used to identify the potential upstream regulatory TFs and downstream signaling pathways, respectively. Co-expression analysis among significantly enriched TFs, key cellular communication genes and differentially expressed signaling pathways were performed to identify key genes and cellular components for SCI-related NeP. Results: A total of 2,314 genes were identified as DEGs between the experimental and the control group. Five proteins (ADRB2, LGALS9, PECAM1, HAVCR2, LRP1) were identified in the overlap of proteins in the significant ligand-receptor interactions of PBMCs and protein-protein interaction (PPI) network based on the DEGs. Only HAVCR2

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Predictors of pressure ulcer incidence following traumatic spinal cord injury: a secondary analysis of a prospective longitudinal study

Abstract: Among individuals with acute traumatic SCI, those with high-injury severity were at an increased risk to develop pressure ulcers. Pneumonia was noted to be associated with the formation of pressure ulcers.

Cited by 67 publications

References 43 publications

Pressure ulcers in individuals with spinal cord injury: risk factors in neurological rehabilitation

Pressure ulcers in individuals with spinal cord injury: risk factors in neurological rehabilitation

The global burden of pressure ulcers among patients with spinal cord injury: a systematic review and meta-analysis

The Integrated Transcriptome Bioinformatics Analysis Identifies Key Genes and Cellular Components for Spinal Cord Injury-Related Neuropathic Pain

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