Predictors of prolonged hospitalization of COVID-19 patients

Lucijanić, Marko; Marelic, Daniela; Stojić, Josip; Marković, Ivan; Sedlić, Filip; Kralj, Ivan; Rucevic, Davor; Bušić, Nikša; Javor, Patrik; Lucijanić, Tomo; Mitrović, Joško; Lukšić, Ivica

doi:10.1007/s41999-023-00787-w

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…The median score for anxiety symptoms was 8 points, IQR (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Anxiety sym were absent in 74 (43.8%), mild in 11 (6.5%), moderate in 29 (17.2%), severe in 9 ( and extremely severe in 46 (27.2%) patients.…”

Section: Anxietymentioning

confidence: 97%

“…Subsequent vaccination program and occurrence of novel, less aggressive viral strains significantly reduced the number of patients presenting with severe and critical forms of the disease. Despite benefits of vaccination, even among those with breakthrough infections [ 4 ], vaccine hesitancy, inadequate immunization among elderly and immunosuppressed patients, as well as waning effects of vaccine-induced immunization remain substantial problems for global control of the COVID-19 pandemic [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Relationship of Anxiety, Depression, Stress, and Post-Traumatic Stress Disorder Symptoms with Disease Severity in Acutely Ill Hospitalized COVID-19 Patients

Lucijanic,

Mihaljevic Peles,

Piskac Zivkovic

et al. 2023

Behavioral Sciences

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We aimed to investigate depression, anxiety, stress, and PTSD symptoms and their relationship with disease severity in acutely ill hospitalized Coronavirus disease 2019 (COVID-19) patients. A single-center cross-sectional observational survey study screening for psychiatric symptoms using the Depression, Anxiety and Stress Scale—21 Items (DASS-21) and the Impact of Events Scale-Revised (IES-R) questionnaires was performed including a total of 169 acutely ill COVID-19 patients. All patients were adults and of white race and developed respiratory insufficiency during hospitalization. Demographic, clinical and laboratory data were evaluated as predictors of psychiatric symptoms. We hypothesized that higher intensity of COVID-19 symptoms and higher oxygen requirement would be associated with occurrence of depression, anxiety, stress, and PTSD symptoms. Depressive symptoms were absent in 29%, mild in 16%, moderate in 27.8%, severe in 10.7% and extremely severe in 16.6% patients. Anxiety symptoms were absent in 43.8%, mild in 6.5%, moderate in 17.2%, severe in 5.3% and extremely severe in 27.2% patients. Stress symptoms were absent in 78.7%, mild in 4.7%, moderate in 7.1%, severe in 7.7%, and extremely severe in 1.8% patients. A total of 60.9% patients had no PTSD symptoms, 16% had undiagnosed symptoms, and 23.1% met the criteria for a PTSD diagnosis. All psychiatric symptoms were more pronounced in female patients, depression and anxiety symptoms were associated with prior chronic obstructive pulmonary disease. Only depressive symptoms were significantly associated with higher intensity of COVID-19 symptoms and higher oxygen requirement. Acutely ill hospitalized COVID-19 patients presented a high prevalence of emergent psychiatric sequelae, especially in females, and more severe COVID-19 influenced mostly the severity of depressive symptoms.

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Section: Anxietymentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Relationship of Anxiety, Depression, Stress, and Post-Traumatic Stress Disorder Symptoms with Disease Severity in Acutely Ill Hospitalized COVID-19 Patients

Lucijanic,

Mihaljevic Peles,

Piskac Zivkovic

et al. 2023

Behavioral Sciences

Self Cite

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“…This is mostly due to an overlapping clinical presentation of both severe COVID-19 and pulmonary embolism, and may be impossible to evaluate properly in clinically unstable patients who are unable to undergo diagnostic procedures [ 16 ]. In addition to medical consequences for the affected patient per se, VTE may lead to prolonged hospital stay and impair the hospital bed network, reflecting the high number of patients who require hospital medical care [ 20 ]. With the introduction of screening methods, much higher proportions of patients with VTE are identified [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients

Lucijanic,

Tjesic-Drinkovic,

Piskac Zivkovic

et al. 2023

Life

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Thromboprophylaxis is a mainstay of treatment of hospitalized COVID-19 patients, due to the high occurrence of thrombotic events. This increases the risk of bleeding. However, data on bleeding events and associated risk factors are scarce. Thus, we aimed to investigate the incidence, predictors and clinical outcomes associated with major bleeding in hospitalized COVID-19 patients. We retrospectively evaluated a cohort of 4014 consecutively hospitalized COVID-19 patients treated in a tertiary-level institution in the period 3/2020–3/2021. Bleeding of any kind was documented in 322 (8%) and major bleeding in 129 (3.2%) patients. A total of 129 (40.1%) bleeding events were present at the time of hospital admission, and 193 (59.9%) occurred during hospitalization. In the multivariate logistic regression analysis, intensive-care-unit treatment (adjusted odds ratio (aOR) 6.55; p < 0.001), atrial fibrillation (aOR 2.55; p = 0.029), higher white-blood-cell count (WBC) (aOR 1.03; p = 0.021), lower hemoglobin (aOR 0.97; p = 0.002) and history of bleeding (aOR 17.39; p < 0.001) were recognized as mutually independent predictors of major bleeding. Major bleeding was significantly associated with increased in-hospital mortality compared to non-major-bleeding patients (59.7% vs. 34.8%, p < 0.001), especially if occurring during hospitalization. Median time from major bleeding to death was 5 days. Bleeding events are frequent in hospitalized COVID-19 patients, with a significant proportion of patients presenting at the time of hospital admission, and others almost universally exposed to anticoagulant and corticosteroid therapies. Major bleeding is associated with high mortality, especially if occurring during hospitalization. The recognition of patients at risk and implementation of timely interventions are of high clinical importance.

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Ferritin at admission as a prognostic marker in older adults hospitalized for COVID-19: A retrospective cohort study

Ramírez Torres,

Sanchez Arizmendi,

Serrano Andrade

et al. 2024

Archives of Gerontology and Geriatrics Plus

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Predictors of prolonged hospitalization of COVID-19 patients

Cited by 7 publications

References 18 publications

Relationship of Anxiety, Depression, Stress, and Post-Traumatic Stress Disorder Symptoms with Disease Severity in Acutely Ill Hospitalized COVID-19 Patients

Relationship of Anxiety, Depression, Stress, and Post-Traumatic Stress Disorder Symptoms with Disease Severity in Acutely Ill Hospitalized COVID-19 Patients

Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients

Ferritin at admission as a prognostic marker in older adults hospitalized for COVID-19: A retrospective cohort study

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