Predictors of protocol adherence in a pediatric asthma clinical trial

Strunk, Robert C.; Bender, Bruce G.; Young, David A.; Sagel, Sharon; Glynn, Emily; Caesar, Mary; Lawhon, Claire

doi:10.1067/mai.2002.128803

Cited by 25 publications

(19 citation statements)

References 15 publications

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“…47 Older children, particularly adolescents, were also less likely to adhere to CPAP therapy, which is consistent with data from studies of adherence to other pediatric medical regimens (see later discussion). 48–50 …”

Section: Factors Influencing Cpap Adherencementioning

confidence: 99%

Improving Positive Airway Pressure Adherence in Children

King

Xanthopoulos

Marcus

2014

Sleep Medicine Clinics

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Section: Factors Influencing Cpap Adherencementioning

confidence: 99%

Improving Positive Airway Pressure Adherence in Children

King

Xanthopoulos

Marcus

2014

Sleep Medicine Clinics

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“…For example, Bender and colleagues [9] found child anxiety and depression to be associated with erratic study participation and withdrawal while Strunk and colleagues [8] reported that mild anxiety was associated with better study protocol adherence. The relation between the child’s disease-specific quality of life and the child’s more general psychological functioning is of considerable interest.…”

Section: Discussionmentioning

confidence: 99%

Predictors of study completion and withdrawal in a randomized clinical trial of a pediatric diabetes adherence intervention

Driscoll

Killian

Johnson

et al. 2009

Contemporary Clinical Trials

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Purpose-Loss of participants in randomized clinical trials threatens the validity of study findings. The purpose of this study was to determine pre-randomization predictors of study withdrawal throughout the course of a randomized clinical trial involving young children with type 1 diabetes and their primary caregivers.Methods-An intervention to improve adherence to the diabetes treatment regimen was delivered as part of the child's regular 3-month diabetes clinic visit. The study protocol involved 7 clinic visits across 18 months for the Immediate Treatment group and 9 clinic visits across 24 months for the Delayed Treatment group. Among those who completed the study and regardless of treatment group, participants were categorized into two groups: On-Time Completers (n = 41) and Late Completers (n = 39). Demographic, disease, and psychosocial characteristics of children and their primary caregivers measured prior to study randomization were tested for their association with the participants' completion status (i.e., On-Time Completers, Late Completers, or Withdrawals).Results-Of the 108 participants, 28 (25.9%) withdrew and 80 (74.1%) completed the study. OnTime Completers (i.e., study completed within 4 months of expected date) were more likely to have private insurance and primary caregivers with some college education. Late Completers (i.e., study completion took longer than 4 months) were more likely to be boys and to have primary caregivers who reported mild to moderate levels of depression. Children who subsequently withdrew from the study reported poorer diabetes-related quality of life and poorer school-related quality of life at study inception and were more likely to have primary caregivers who did not work outside the home.Conclusions-Pre-randomization screening of participants on both demographic and psychological variables may help identify those at greatest risk for study withdrawal or poor study protocol adherence, permitting the investigators to develop retention strategies aimed at this highrisk group.

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“…[1][2][3][4][5][6][7] Poor adherence is a particular problem among patients who are prescribed antipsychotic medications, including those diagnosed with either schizophrenia [8][9][10] or bipolar disorder. [11][12][13] It has been estimated that as many as 50% of patients with schizophrenia adhere poorly to their medication regimens.…”

Section: Introductionmentioning

confidence: 99%

An Attempt to Improve Antipsychotic Medication Adherence by Feedback of Medication Possession Ratio Scores to Prescribers

Patel¹,

Ni²,

Clayton³

et al. 2010

Population Health Management

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Poor medication adherence is well documented for patients with severe and persistent mental illness. The State of Missouri implemented an early alert system to notify caregivers when patients fail to refill essential prescriptions in a timely manner and as an educational resource for providers on best practices for improving treatment adherence. Missouri Medicaid patients who were prescribed at least 1 of 9 orally-administered antipsychotic medications and who had at least 1 medication possession ratio (MPR) score below 0.8 were included in the adherence intervention group. Their prescribing clinicians and case managers were messaged electronically 2 times per week at the point that failure to refill the targeted prescription was identified. Notification occurred when the prescription had lapsed at 7 days, 30 days, and 45 days, and occurred in real time. In addition, MPR scores were provided monthly for the most recent 6-month period. Change in MPR scores was measured for the intervention group and for a matched control group. Trends in MPR scores were analyzed for both groups pre, during, and post intervention. In both the intervention and postintervention periods, there was a significant difference in the MPR scores between the two groups. The intervention group had a significantly greater increase in MPR score between preintervention and intervention periods. After the conclusion of the intervention, the MPR score decreased somewhat but was still higher than during the preintervention period. Results suggest that clinicians and patients need specific data about adherence in order to address the issue.

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Predictors of protocol adherence in a pediatric asthma clinical trial

Cited by 25 publications

References 15 publications

Improving Positive Airway Pressure Adherence in Children

Improving Positive Airway Pressure Adherence in Children

Predictors of study completion and withdrawal in a randomized clinical trial of a pediatric diabetes adherence intervention

An Attempt to Improve Antipsychotic Medication Adherence by Feedback of Medication Possession Ratio Scores to Prescribers

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