Predictors of Readmission After Pulmonary Resection in Patients With Lung Cancer: A Systematic Review and Meta-analysis

Liu, JIe; Yang, Xuyan; Liu, Xing; Xu, Yan; Huang, Hao

doi:10.1177/15330338221144512

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Zeng et al examined 181 patients with advanced NSCLC with T2DM and suggested that hypertension may worsen their prognosis [ 69 ]. Among patients with lung cancer, another related study also suggests that hypertension is not a risk factor for postoperative readmission [ 70 ]. The differences in these results may be influenced by sample size, age of participants and the use of antihypertensive drugs.…”

Section: Discussionmentioning

confidence: 99%

Association between insulin resistance, metabolic syndrome and its components and lung cancer: a systematic review and meta-analysis

Liu,

Wang,

Tan

et al. 2024

Diabetol Metab Syndr

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Background A growing body of evidence points to the association between insulin resistance (IR), metabolic syndrome (MetS) and its components and lung cancer incidence, but remains controversial and unknown. Methods A systematic search was conducted through PubMed, Embase, Cochrane Library, the China National Knowledge Infrastructure (CNKI) and Wanfang databases for the corresponding studies. Each study reported the risk estimate and 95% confidence intervals (CI) for lung cancer, and a fixed effects model or random effects model was used for outcome. Results We included 31 publications involving 6,589,383 people with 62,246 cases of lung cancer. Diabetes mellitus (DM) (RR = 1.11, 95% CI 1.06–1.16, P = 0.000) and IR (RR = 2.35, 95% CI 1.55–3.58, P = 0.000) showed a positive association with lung cancer risk. BMI (RR = 0.66, 95% CI 0.54–0.81, P = 0.000) and HDL-C (RR = 0.88, 95% CI 0.79–0.97, P = 0.010) were negatively correlated with lung cancer. MetS(RR = 0.99, 95% CI 0.90–1.09, P = 0.801), TC (RR = 0.93, 95% CI 0.81–1.06, P = 0.274), TG (RR = 0.99, 95% CI 0.88–1.12,P = 0.884), LDL-C (RR = 1.01, 95% CI 0.87–1.16, P = 0.928), hypertension (RR = 1.01, 95% CI 0.88–1.15, P = 0.928), FBG (RR = 1.02, 95% CI 0.92–1.13, P = 0.677) and obesity (RR = 1.11, 95% CI 0.92–1.35, P = 0.280) were not associated with lung cancer. Conclusion Our study showed that the risk of lung cancer is correlated with DM, IR, BMI, and HDL-C. Timely control of these metabolic disorders may have a positive effect on preventing lung cancer. Trial registration Our study has been registered in the Prospective Register of Systematic Reviews (PROSPERO), ID: CRD42023390710.

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Section: Discussionmentioning

confidence: 99%

Association between insulin resistance, metabolic syndrome and its components and lung cancer: a systematic review and meta-analysis

Liu,

Wang,

Tan

et al. 2024

Diabetol Metab Syndr

View full text Add to dashboard Cite

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“…Prolonged PAL (pPAL), defined as PAL lasting longer than 5 days, affects 5.6–30% of patients ( 1 ). pPAL is the main reason for delayed chest tube removal, prolonged hospital stay and readmissions ( 2 - 4 ), while resulting in more complications including empyema ( 5 ), pneumonia ( 6 , 7 ) and mortality ( 8 ). Furthermore, 4.8% of patients with pPAL require additional interventions (extra chest tubes, bronchoscopy and reoperation) ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Sealing effectiveness of a novel NHS-POx based patch: experiments in a dynamic ex vivo porcine lung

Hermans¹,

Li²,

Roozen³

et al. 2023

J Thorac Dis

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Background Sealants are used to prevent prolonged pulmonary air leakage (PAL) after lung resections (incidence 5.6–30%). However, clinical evidence to support sealant use is insufficient, with an unmet need for a more effective product. We compared a novel gelatin patch impregnated with functionalized polyoxazolines (NHS-POx) (GATT-Patch) to commercially available sealant products. Methods GATT-Patch Single/Double layers were compared to Progel ® , Coseal ® , Hemopatch ® and TachoSil ® in an ex vivo porcine lung model (first experiment). Based on these results, a second head-to-head comparison between GATT-Patch Single and Hemopatch ® was performed. Air leakage (AL) was assessed in three settings using increasing ventilatory pressures (max =70 cmH 2 O): (I) baseline, (II) with 25 mm × 25 mm superficial pleural defect, and (III) after sealant application. Lungs floating on saline (37 ℃) were video recorded for visual AL assessment. Pressure and tidal volumes were collected from the ventilator, and bursting pressure (BP), AL and AL-reduction were determined. Results Per sealant 10 measurements were performed (both experiments). In the first experiment, BP was superior for GATT-Patch Double (60±24 cmH 2 O) compared to TachoSil ® (30±11 cmH 2 O, P<0.001), Hemopatch ® (33±6 cmH 2 O, P=0.006), Coseal ® (25±13 cmH 2 O, P=0.001) and Progel ® (33±11 cmH 2 O, P=0.005). AL-reduction was superior for GATT-Patch Double (100%±1%) compared to Hemopatch ® (46%±50%, P=0.010) and TachoSil ® (31%±29%, P<0.001), and also for GATT-Patch Single (100%±14%, P=0.004) and Progel (89%±40%, P=0.027) compared to TachoSil ® . In the second experiment, GATT-Patch Single was superior regarding BP (45±10 vs. 40±6 cmH 2 O, P=0.043) and AL-reduction (100%±11% vs. 68%±40%, P=0.043) when compared to Hemopatch ® . Conclusions The novel NHS-POx patch shows promise as a lung sealant, demonstrating elevated BP, good adhesive strength and a superior AL-reduction.

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Outcomes and Survival for Early-Stage Non-Small Cell Lung Cancer Following Wedge Resection or Lobectomy: A Propensity Score-Matched Analysis Using a Novel Peruvian Registry

Llalle,

Albán-Sánchez,

Torres-Neyra

et al. 2024

J Chest Surg

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Background Using a previously unreported Peruvian registry of patients treated for early-stage non-small cell lung cancer (NSCLC), this study explored whether wedge resection and lobectomy were equivalent regarding survival and impact on radiologic-pathologic variables. Methods This observational, analytical, longitudinal study used propensity score-matched (PSM) analysis of a single-center retrospective registry of 2,570 patients with pathologic stage I–II NSCLC who were treated with wedge resection (n=1,845) or lobectomy (n=725) during 2000–2020. After PSM, 650 cases were analyzed (resection, n=325; lobectomy, n=325) through preoperative and clinical variables, including patients with ≥1 lymph node removed. Kaplan-Meier curves and multivariable Cox proportional hazard models were created for 5-year overall survival (OS), disease-free survival (DFS), and locoregional-recurrence-free survival (LRFS). Results The principal complication was operative pain persisting >7 days for lobectomy versus wedge resection (58% vs. 23%, p=0.034) and shorter hospital stays for resection than for lobectomy (5.3 days vs. 12.8 days, p=0.009). The 5-year OS (84.3% vs. 81.2%, p=0.09) and DFS (79.1% vs. 74.1%, p=0.07) were similar and statistically insignificant between resections and lobectomies, respectively. LRFS was worse overall following wedge resection than lobectomy (79.8% vs. 91.1%, p<0.02). Nevertheless, in the PSM analysis, both groups experienced similar LRFS when the resection margin was >10 mm (90.9% vs. 87.3%, p<0.048) and ≥4 lymph nodes were removed (82.8% vs. 79.1%, p<0.011). Conclusion Both techniques led to similar OS and DFS at 5 years; however, successful LRFS required a wedge resection with a surgical margin and adequate lymph node removal to obtain outcomes similar to lobectomy.

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Predictors of Readmission After Pulmonary Resection in Patients With Lung Cancer: A Systematic Review and Meta-analysis

Cited by 4 publications

References 30 publications

Association between insulin resistance, metabolic syndrome and its components and lung cancer: a systematic review and meta-analysis

Association between insulin resistance, metabolic syndrome and its components and lung cancer: a systematic review and meta-analysis

Sealing effectiveness of a novel NHS-POx based patch: experiments in a dynamic ex vivo porcine lung

Outcomes and Survival for Early-Stage Non-Small Cell Lung Cancer Following Wedge Resection or Lobectomy: A Propensity Score-Matched Analysis Using a Novel Peruvian Registry

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