Predictors of Recurrence After Local Excision and Postoperative Chemoradiation Therapy of Adenocarcinoma of the Rectum

Bouvet, Michael; Milas, Mira; Giacco, Geoffrey G.; Cleary, Karen R.; Janjan, Nora A.; Skibber, John M.

doi:10.1007/s10434-999-0026-3

Cited by 65 publications

(37 citation statements)

References 16 publications

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“…In single-arm studies, especially in T2 stage I rectal cancers, high rate of local recurrence, i.e. 28%, was detected, despite the administration of post-operative chemoradiotherapy (Ota et al, 1992;Bleday et al, 1997;Bouvet et al, 1999;Chakravarti et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Recurrence Risk and Prognostic Parameters in Stage I Rectal Cancers

Cihan

Küçüköner²,

Özdemir³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 99%

Recurrence Risk and Prognostic Parameters in Stage I Rectal Cancers

Cihan

Küçüköner²,

Özdemir³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Recent studies reported the incidence of local failure as 0-5% for T1, 10-20% for T2, and 24-50% for T3 lesions [17,18]. In these studies, recurrence was also more likely to occur in patients with positive margins than in those with negative margins.…”

Section: Discussionmentioning

confidence: 48%

The Place of the Posterior Surgical Approach for Lesions of the Rectum

et al. 2005

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Background: Although there are many advantages of a posterior approach to rectal disease, these procedures are not widely accepted because many surgeons fear the postoperative complications. Methods: The medical records were reviewed of 57 patients who underwent a posterior approach to the rectum between January 1980 and December 2002. Results: Twenty-eight men and 29 women with a mean age of 70.5 (range 47–83) years underwent either a posterior transsacral (n = 52) or a transsphincteric (n = 5) procedure. Indications for surgery were benign lesions (n = 33), e.g. villous adenoma, rectal prolapse and endometriosis as well as invasive adenocarcinoma (n = 24). All patients with an invasive adenocarcinoma were classified as ASA grade III or IV. Postoperative morbidity occurred in 12 patients (21%), consisting of temporary incontinence, anastomotic leakage, wound infection, and hemorrhage. There was no mortality. During a mean follow-up of 29 (range 2–86) months, 3 patients with a villous adenoma and 2 patients who were treated for a malignant lesion had a locally recurrent lesion. Conclusion: We believe that a posterior approach to the rectum should be considered for various benign and selected malignant diseases, especially in case of elderly patients or patients with a compromised general condition, and has to be a part of the surgeon’s armamentarium.

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“…T1 tumors have a 6-12% incidence of lymph node (LN) involvement, T2 tumors have positive lymph nodes (LNs) in 17-22% of the cases and T3 tumors have LN involvement in m o r e t h a n 6 6 % o f t h e c a s e s . T h e aforementioned differences are reported to result in different 5-year local recurrence rates, namely 5% for T1 tumors, 18% for T2 tumors and 22-33% for T3 tumors (Bouvet et al, 1999 www.intechopen.com…”

Section: Indicationsmentioning

confidence: 99%