Predictors of Relapse to Harmful Alcohol After Orthotopic Liver Transplantation

Abstract

A model based on readily defined behaviours and psychosocial factors predicted relapse to harmful drinking after transplant for ALD. This model may improve assessment and post-transplant management of patients with advanced ALD.

Risk Factors for Alcohol Relapse Following Orthotopic Liver Transplantation: A Systematic Review

“…38 Table 1 provides a summary of recent (published in 2006 or later) retrospective studies examining risk of alcohol relapse following OLT in patients with ALD. [39][40][41][42][43][44][45][46][47] Table 2 summarizes recent (published in 2006 or later) prospective studies (arguably less subject to bias than retrospectively designed research) examining risk of alcohol relapse following OLT in patients with ALD. 32,48-50 DiMartini et al 32 initiated a prospective study in 1998 of post-liver transplantation alcohol consumption in ALD recipients using multiple repeatedmeasures analysis of alcohol use (i.e., the AlcoholTimeline Follow-Back questionnaire, 51,52 a caregiver questionnaire patterned after the National Institute on Alcohol Abuse and Alcoholism Quantity-Frequency measure, 53 clinical interviews performed by the transplantation psychiatrist who was blinded to the data obtained by the research staff, and blood alcohol levels).…”

Review article: depression and the use of antidepressants in patients with chronic liver disease or liver transplantation

“…Patients were equally as likely to have developed depression before using alcohol excessively as they were afterwards. 43 Risk factors for alcohol recidivism after OLT have been found to include pre-operative depression and level of alcohol consumption, 44 with the evidence regarding the extent to which duration of pre-transplant abstinence contributes being contradictory.…”

Untitled

“…Evaluation of the support system is an important part in the evaluation of the patients' transplant candidacy, and its importance has been well reported. 23 We evaluated various other high risk traits or situations generally associated with alcohol consumption including history of psychiatric comorbidities, use of other substances abuse, criminal history, and driving under the influence. Alcohol relapse-free survival also was poor in recipients with non-alcohol related criminal history by Kaplan-Meier survival analysis, but it was significant only on univariate Cox proportional hazard model but not on multivariate analysis.…”