Predictors of Renal Complications in Children With Hematotoxic Snakebite

Islam, Kamirul; Seth, Soutrik; Roy, Ajitesh; Datta, Anuja

doi:10.1007/s13312-020-1817-7

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…Kidney tissue obtained during the early diuretic phase of acute tubular necrosis (ATN) revealed epithelial degeneration in tubules, tubular vacuolation, desquamation, and severe intertubular interstitial oedema with regenerative changes developing at the later stages of AKI (after 3 to 8 weeks). (11,19,33) Interstitial haemorrhage was more common in the 1st week of the bite. (27) The nature of the tubular casts also changed with the time lag between the bite and kidney biopsy.…”

Section: Timing and Indication Of Renal Biopsymentioning

confidence: 98%

“…Overall we included a total of 534 renal biopsies and 107 renal autopsy ndings. Two studies, (8, 19)were exclusively done on children with a mean age of 11.52 ± 2.88 years and 5.8 ± 1 years respectively. In the majority of studies, AKI was caused by Russell's viper, however, in some studies, Echis carinatus and sea snakes were also identi ed to be associated with kidney involvement.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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The kidney histopathological spectrum of patients with kidney injury following Snakebite Envenomation in India: Scoping Review of Five Decades

Meena,

Bhargava,

Gupta

et al. 2023

Preprint

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Introduction: Snakebite is a public health problem leading to about 55,000 deaths every year in India. Kidney injury subsequent to snakebite envenomation is common ( reported prevalence is up to 32%). The current study aims to elucidate the spectrum of kidney histopathology in acute kidney injury (AKI) cases followed by snake bites. Methods: We searched seven electronic database studies to identify studies describing the histopathological findings in the kidney with snakebite envenomation. Two reviewers independently conducted titles and abstract screening as well as full-text evaluation for the final inclusion decision. Data were extracted as per a standardized form and conducted narrative synthesis. Studies done exclusively on autopsy findings, in vitro studies, and case reports were excluded. Results: We retrieved 1810 studies and finally included 28 studies which met the eligibility criteria in the analysis. Most studies were single-centre and the majority were cross-sectional. Overall we included a total of 534 renal biopsies. Russell's viper bite was the commonest cause related to AKI. Acute tubular necrosis was the most common finding followed by acute interstitial nephritis, acute cortical necrosis, and thrombotic microangiopathy. Vasculitis changes in vessels were rarely reported. The clinical presentation and prognosis of the patients were directly proportional to the severity of the renal histopathological lesion. Conclusion: This analysis supports the notion that renal biopsies are of utmost importance to guide prognosis and increase our knowledge about post- snake bite AKI pathophysiology

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Section: Timing and Indication Of Renal Biopsymentioning

confidence: 98%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

The kidney histopathological spectrum of patients with kidney injury following Snakebite Envenomation in India: Scoping Review of Five Decades

Meena,

Bhargava,

Gupta

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Overall we included a total of 534 renal biopsies and 107 renal autopsy findings. Supplementary appendix 1 shows PRISMA-ScR Checklist for the reported studies Two studies, [22,31] were exclusively done on children with a mean age (± SD) in years of 11.52 ± 2.88 years and 5.8 ± 1.0 years respectively. In the majority of studies, AKI was caused by Russell's viper, however, in some studies, Echis carinatus and sea snakes were also identified to be associated with kidney involvement [15-17, 27, 29].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Histopathological findings in Kidney biopsies of included studies are shown in Table 2. Kidney tissue obtained during the early diuretic phase of acute tubular necrosis (ATN) revealed epithelial degeneration in tubules, tubular vacuolation, desquamation, and severe intertubular interstitial oedema with regenerative changes developing at the later stages of AKI (after 3 to 8 weeks) [9,30,31]. Interstitial haemorrhage was more common in the 1st week of the bite [15].…”

Section: Timing and Indication Of Renal Biopsymentioning

confidence: 99%

The kidney histopathological spectrum of patients with kidney injury following snakebite envenomation in India: scoping review of five decades

Meena,

Bhargava,

Gupta

et al. 2024

BMC Nephrol

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Introduction Snakebite is a public health problem leading to about 58,000 deaths every year in India. Kidney injury subsequent to snakebite envenomation is common with a reported prevalence of up to 32%. The current study aims to elucidate the spectrum of kidney histopathology in acute kidney injury (AKI) cases associated with snake bites. Methods We searched seven electronic database studies to identify studies describing the histopathological findings in the kidney with snakebite envenomation. Two reviewers independently conducted titles and abstract screening as well as full-text evaluation for the final inclusion decision. Data were extracted as per the standardized form. We conducted narrative synthesis. Studies done exclusively on autopsy findings, in vitro studies, and case reports were excluded. Results We retrieved 1464 studies and finally included 28 studies which met the eligibility criteria in the analysis. Most studies were single-centre and the majority were cross-sectional. Overall we included a total of 534 renal biopsies. Russell’s viper bite was the most common cause related to AKI. Acute tubular necrosis was the most common finding followed by acute interstitial nephritis, acute cortical necrosis (ACN), and thrombotic microangiopathy (TMA). Vasculitis changes in vessels were rarely reported. Lesions such as ACN and TMA were associated with poor outcomes. Conclusion This analysis supports the notion that renal biopsies are important to guide prognosis and increase our knowledge about post-snake bite AKI pathophysiology.

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“…In the first case, the immaturity of the immune system and low body weight compared to adults becomes the cause of the development of severe complications [1,9,21]. In the second case, as a result of disorders of the coagulation system and, accordingly, haemorrhages or thrombosis, it is possible to terminate pregnancies at different times [17,23,28].…”

Section: Introductionmentioning

confidence: 99%

Morphological state of lungs of rats under the influence of Vipera berus berus venom

Lasavutz,

Yaremenko,

Butska

et al. 2024

Rep. of Morph.

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About 5.4 million snake bite cases are registered worldwide every year. About half of them cause 81,000-138,000 deaths or disabled 400,000 people. Despite this, this problem is neglected in many countries in Asia, Africa and Latin America. It is believed that death from snakebites is associated with poverty since the lack of proper access to medical facilities in such sections of the population causes the development of fatal complications. The purpose of the study is to study the morphological state of rats' lungs under exposure to Vipera berus berus venom. Experimental studies were carried out on white, non-linear male rats. Animals were conditionally divided into control and experimental groups, ten individuals each. Experimental rats were injected intraperitoneally with a semi-lethal dose (LD50) (1.576 mg/g-1) of Vipera berus berus venom in a physiological solution. Animals of the control group were injected intraperitoneally with only a physiological solution. Rats were removed from the experiment 24 hours after exposure to the poison and anaesthetized by cervical dislocation. Lung tissue samples were taken for microscopic examination. Fixation of the material and preparation of paraffin blocks were carried out according to generally accepted methods. Staining of histological preparations of the lungs was carried out with hematoxylin and eosin, according to Masson, and the PAS+"Hale" reaction was carried out according to the Mowry method. Histological preparations were studied using an SEO SСAN light microscope. The toxic effect of Vipera berus berus venom caused significant changes in the vascular, stromal and parenchymal components, which was confirmed by histological, histochemical and morphometric data. In the lungs of experimental animals, the vascular bed is primarily restructured, forming coagulopathies and thrombosis. The development of DIC syndrome and haemorrhages accompanies an increase in the permeability of the vessel wall. Inflammatory phenomena are found in the bronchi and respiratory departments' walls. There is a remodelling of the respiratory department components, with the formation of significant areas of dis- and atelectasis and zones of emphysema, which is confirmed morphometrically.

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Predictors of Renal Complications in Children With Hematotoxic Snakebite

Cited by 6 publications

References 10 publications

The kidney histopathological spectrum of patients with kidney injury following Snakebite Envenomation in India: Scoping Review of Five Decades

The kidney histopathological spectrum of patients with kidney injury following Snakebite Envenomation in India: Scoping Review of Five Decades

The kidney histopathological spectrum of patients with kidney injury following snakebite envenomation in India: scoping review of five decades

Morphological state of lungs of rats under the influence of Vipera berus berus venom

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