Predictors of respiratory epithelial adenomatoid hamartomas of the olfactory clefts in patients with nasal polyposis

Nguyen, Duc Trung; Nguyen-Thi, Phi-Linh; Gauchotte, Guillaume; Arous, Fabien; Vignaud, J; Jankowski, R.

doi:10.1002/lary.24778

Cited by 23 publications

(31 citation statements)

References 25 publications

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“…It is very interesting a frequent association between nasal polyposis and bilateral REAH of the olfactory cleft. Nguyen et al [7] found that the development of REAH in patients with nasal polyposis is induced by a long-lasting and/or severe inflammation of the nasal mucosa in the olfactory cleft region. A subtype of REAH, chondro-osseous respiratory epithelial adenomatoid hamartoma (COREAH) is an extremely rare entity that contains islands of cartilage and mature bone interspersed throughout the lesion [8].…”

Section: Discussionmentioning

confidence: 99%

Huge Respiratory Epithelial Adenomatoid Hamartoma Originating from the Inferior Nasal Turbinate: A Case Report

Perić

Bijelić

Vukomanović-Đurđević

et al. 2015

Indian J Otolaryngol Head Neck Surg

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Respiratory epithelial adenomatoid hamartoma (REAH) is a recently described entity consisted of benign glandular proliferations lined by pseudostratified respiratory epithelium. We report a case of a 22-year-old male patient with 7-year history of nasal obstruction and headache resulting from a huge left-sided nasal lesion. Computed tomography, magnetic resonance and biopsy were performed to make a provisional diagnosis of REAH originating from the left-sided inferior turbinate. The definitive diagnosis of REAH was made by histopathological examination of the removed mass. We also discuss the origin and differential diagnosis of these rare lesions.

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Section: Discussionmentioning

confidence: 99%

Huge Respiratory Epithelial Adenomatoid Hamartoma Originating from the Inferior Nasal Turbinate: A Case Report

Perić

Bijelić

Vukomanović-Đurđević

et al. 2015

Indian J Otolaryngol Head Neck Surg

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“…2,4 The term "REAH" is not accurate, as it does not respond to the criteria laid out in the definition of a hamartoma. 2,4 Thus, it is a hyperplasia of the respiratory epithelium rather than a hamartoma. 4 The treatment for REAH is endoscopic surgery without need of a large resection.…”

Section: Discussionmentioning

confidence: 99%

“…2,4 Thus, it is a hyperplasia of the respiratory epithelium rather than a hamartoma. 4 The treatment for REAH is endoscopic surgery without need of a large resection. 2 On the contrary, imaging criteria for the diagnosis of REAH-OCs were the bilaterality of masses in the OC, large OC/small OC ratio <2, and no bone erosion.…”

Section: Discussionmentioning

confidence: 99%

“…In 2006, the origin of REAHs in the olfactory cleft (REAH‐OC) was first reported . They are frequently observed inside the OC of patients with nasal polyposis, especially in those with previous sinus surgery …”

Section: Introductionmentioning

confidence: 99%

“…3 They are frequently observed inside the OC of patients with nasal polyposis, 2-5 especially in those with previous sinus surgery. 4,5 Histopathologically, REAHs can be confused with malignant tumours, especially in the case of small biopsies. 6…”

Section: Introductionmentioning

confidence: 99%

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Difference between respiratory epithelial adenomatoid hamartomas and small malignant tumours of the olfactory cleft on CT scans in forty‐six patients

Hilaire

Rumeau

Gallet

et al. 2017

Clinical Otolaryngology

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Outcomes and imaging findings of respiratory epithelial adenomatoid hamartoma: a systematic review

Safi

Tabaee

et al. 2019

Int Forum Allergy Rhinol

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BackgroundRespiratory epithelial adenomatoid hamartoma (REAH) is a recently classified histopathologic diagnosis often identified incidentally following endoscopic sinus surgery (ESS) for presumed chronic rhinosinusitis. Limited data exist defining preoperative imaging features and surgical outcomes. The purpose of this study is to examine characteristic imaging findings of REAH and postoperative olfactory and recurrence outcomes.MethodsA systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guidelines on articles published from 1995 to present. PubMed, EMBASE, and Ovid MEDLINE databases were queried for studies pertinent to imaging findings of REAH and surgical outcomes. Quality of articles was assessed using the Methodological Index for Non‐Randomized Studies (MINORS).ResultsA total of 294 articles were identified, with 15 meeting inclusion criteria. Seven articles assessed both imaging findings and surgical outcomes. Three articles focused exclusively on imaging, whereas 5 examined surgical outcomes. Olfactory cleft (OC) widening greater than 10 mm on computed tomography (CT) was characteristic of REAH. A total of 441 patients with REAH were included; 221 patients (50.1%) had concurrent nasal polyposis, whereas 154 patients (34.9%) had isolated REAH. Surgical intervention ranged from simple excision to complete ESS. Sixty‐five percent (65%) of patients reported improved olfaction; 4.1% of patients recurred with follow‐up ranging from 4 months to 5 years.ConclusionA widened OC may suggest the presence of REAH. This disease process has been identified in patients with nasal polyposis or encountered as an isolated lesion. Targeted surgery may result in improved olfaction and a low likelihood of recurrence, though long‐term prospective studies are necessary.

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Predictors of respiratory epithelial adenomatoid hamartomas of the olfactory clefts in patients with nasal polyposis

Abstract: 4.

Cited by 23 publications

References 25 publications

Huge Respiratory Epithelial Adenomatoid Hamartoma Originating from the Inferior Nasal Turbinate: A Case Report

Huge Respiratory Epithelial Adenomatoid Hamartoma Originating from the Inferior Nasal Turbinate: A Case Report

Difference between respiratory epithelial adenomatoid hamartomas and small malignant tumours of the olfactory cleft on CT scans in forty‐six patients

Outcomes and imaging findings of respiratory epithelial adenomatoid hamartoma: a systematic review

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