Predictors of Sleep Apnea in the Canadian Population

Spuy, Ina van der; Zhao, Gaungming; Karunanayake, Chandima; Pahwa, Punam

doi:10.1155/2018/6349790

Cited by 17 publications

(11 citation statements)

References 85 publications

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“…Specifically, OSA is known to affect uncontrolled HTN; however, it remains unclear how HTN affects the incidence or severity of OSA, as well as the risk factors for OSA. Some studies have reported HTN as a risk factor or predictor for OSA [30][31][32]; with certain medications for controlling HTN affecting OSA severity [33]. Further, the similarity of risk factors between HTN and OSA, including age, male sex, and obesity, may have influenced the analysis of HTN as a risk factor of OSA.…”

Section: <A Clinical Formula With Physical Examination Factors>mentioning

confidence: 99%

Risk factors and clinical prediction formula for the evaluation of obstructive sleep apnea in Asian adults

et al. 2021

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Obstructive sleep apnea is a highly prevalent cyclic repetitive hypoxia-normoxia respiratory sleep disorder characterized by intermittent upper-airway collapse. It is mainly diagnosed using in-laboratory polysomnography. However, the time-spatial constraints of this procedure limit its application. To overcome these limitations, there have been studies aiming to develop clinical prediction formulas for screening of obstructive sleep apnea using the risk factors for this disorder. However, the applicability of the formula is restricted by the group specific factors included in it. Therefore, we aimed to assess the risk factors for obstructive sleep apnea and develop clinical prediction formulas, which can be used in different situations, for screening and assessing this disorder. We enrolled 3,432 Asian adult participants with suspected obstructive sleep apnea who had successfully undergone in-laboratory polysomnography. All parameters were evaluated using correlation analysis and logistic regression. Among them, age, sex, hypertension, diabetes mellitus, anthropometric factors, Berlin questionnaire and Epworth Sleepiness Scale scores, and anatomical tonsil and tongue position were significantly associated with obstructive sleep apnea. To develop the clinical formulas for obstructive sleep apnea, the participants were divided into the development (n = 2,516) and validation cohorts (n = 916) based on the sleep laboratory visiting date. We developed and selected 13 formulas and divided them into those with and without physical examination based on the ease of application; subsequently, we selected suitable formulas based on the statistical analysis and clinical applicability (formula including physical exam: sensitivity, 0.776; specificity, 0.757; and AUC, 0.835; formula without physical exam: sensitivity, 0.749; specificity, 0.770; and AUC, 0.839). Analysis of the validation cohort with developed formulas showed that these models and formula had sufficient performance and goodness of fit of model. These tools can effectively utilize medical resources for obstructive sleep apnea screening in various situations.

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Section: <A Clinical Formula With Physical Examination Factors>mentioning

confidence: 99%

Risk factors and clinical prediction formula for the evaluation of obstructive sleep apnea in Asian adults

et al. 2021

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“…To our knowledge, the current study is substantially larger than any similar study published to date. 24,37,38 We found that most forms of physical activity had a significant protective association with OSA prevalence, independent of potential confounding covariates including BMI. The subtypes of physical activity were assessed separately; increased walking and vigorous-intensity activity were both associated with reduced OSA prevalence.…”

Section: Principal Findingsmentioning

confidence: 79%

Physical activity is associated with reduced prevalence of self-reported obstructive sleep apnea in a large, general population cohort study

Hall

Singh

Mukherjee

et al. 2020

Journal of Clinical Sleep Medicine

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Study Objectives: Obstructive sleep apnea (OSA) is a common condition with significant symptoms and long-term adverse cognitive, mental health, vascular, and respiratory sequelae. Physical activity has been recognized as a key determinant for good health and has been associated with lower risk of these sequelae. We hypothesized that increased physical activity may be associated with a decreased prevalence of OSA. Methods: This cross-sectional study used baseline questionnaire data from the Ontario Health Study, a population-based cohort of residents of Ontario, Canada. Participants were adults who provided lifestyle, medical, socio-demographic, and sleep health information. The study sample consisted of 155,448 men (39.8%) and women (60.2%). The prevalence of physician-diagnosed OSA in this cohort was 6.9%. Logistic regression models were used to investigate the association of OSA with physical activity. Missing data were imputed using a multiple imputation by chained equation approach. Results: In multivariable analyses adjusted for potential confounding factors, increased total physical activity (metabolic equivalent [h/wk]) (odds ratio [OR] = .98, 95% confidence interval [CI] = .96 to 1.00), vigorous-intensity activity (OR = .98, 95% CI = .97 to 1.00), and walking (OR = .98, 95% CI = .96 to 1.00) were all associated (all P ≤ .045) with decreased prevalence of OSA. Moderate-intensity activity was not associated with risk of OSA (P = .826). Conclusions: Independent of known risk factors for OSA, including body mass index, increased levels of physical activity, including walking, were associated with a prevalence of OSA. Our results highlight the importance of physical activity as a preventive measure for sleep apnea.

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“…Combined, an estimated 5.4 million adults have been diagnosed with sleep apnea or are at high risk of developing it (1). Sleep apnea is characterized by repeated cessation of breathing due to a lack of airflow during sleep (2). Of the many types of apneas, obstructive sleep apnea (OSA) is the most common.…”

Section: Main Textmentioning

confidence: 99%

Medicinal Marijuana: A Promising Potential Treatment for Obstructive Sleep Apnea

Rai

Thakker²,

Patel³

2019

OSURJ

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Obstructive Sleep Apnea (OSA) is a common sleep disorder in mammals which is characterized by the repeated collapse of the upper airway. It is a known cause of hypertension, cardiovascular disease, and, in some cases, death. OSA is commonly treated by medical devices and surgeries. Although effective, these treatments are associated with unwanted side-effects and further complications. In recent years, the role of medicinal marijuana has grown as a potential treatment for sleep disorders. Further research must be conducted to determine the efficacy and safety of cannabis as a treatment for OSA.

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Predictors of Sleep Apnea in the Canadian Population

Cited by 17 publications

References 85 publications

Risk factors and clinical prediction formula for the evaluation of obstructive sleep apnea in Asian adults

Risk factors and clinical prediction formula for the evaluation of obstructive sleep apnea in Asian adults

Physical activity is associated with reduced prevalence of self-reported obstructive sleep apnea in a large, general population cohort study

Medicinal Marijuana: A Promising Potential Treatment for Obstructive Sleep Apnea

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