Predictors of Steroid Hormone Concentrations in Early Pregnancy: Results from a Multi-Center Cohort

Barrett, Emily S.; Mbowe, Omar; Thurston, Sally W.; Butts, Samantha; Wang, Christina; Nguyen, Ruby H.N.; Bush, Nicole R.; Redmon, J. Bruce; Sheshu, Sukrita; Swan, Shanna H.; Sathyanarayana, Sheela

doi:10.1007/s10995-018-02705-0

Cited by 24 publications

(16 citation statements)

References 59 publications

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“…Statistically significant difference was found in the serum values of DHEA and androstenedione considering maternal parity, with lower values in the group of multiparous woman. The results are consistent with available research by Arslaan et al 33 , Musey et al, 34 Toriola et al, 35 and Barrett et al 36 So far, no explanation has been found for differences in the steroid hormone profile depending on parity. Possible explanations include differences in placental size and its activity in primiparous and multiparous women, differences in the concentration of hormone‐binding proteins in primiparous and multiparous mothers, which reduces hormone bio availability and their function, in the modulation of hormone receptor expression, and in altered maternal hormone metabolism 33,36 …”

Section: Discussionsupporting

confidence: 92%

Requirement for oxytocin augmentation in spontaneous parturition is associated with the maternal serum steroid hormones assessed by liquid chromatography coupled to the tandem mass spectrometry

Kadivnik

Debeljak

Mandić

et al. 2021

J of Obstet and Gynaecol

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Aim The aim of research was to evaluate the maternal serum concentration of selected endogenous steroid hormones during spontaneous parturition at term and to determinate their association with the need for oxytocin augmentation. Methods Blood of 108 healthy pregnant women whose parturition started with the regular spontaneous uterine contractions was drawn at the beginning of the labor. Liquid chromatography coupled to the tandem mass spectrometry device was utilized for measurement of sex hormone binding globulin, aldosterone, androstenedione, cortisol, cortisone, corticosterone, dehydroepiandrosterone, dehydroepiandrosteron sulphate, 17‐hydroxyprogesterone, progesterone, and testosterone. Mann–Whitney U test, chi‐square test, univariate and multivariate logistic regression, and receiver operating characteristic (ROC) analysis were used for the data analysis. Results Reference ranges of the selected hormones assessed by liquid chromatography coupled to the tandem mass spectrometry in maternal serum were established. Statistically significant differences in the serum concentration of corticosterone, dehydroepiandrosterone, and androstenedione between mothers requiring oxytocin augmentation and the rest of women having spontaneous parturition were found (p = 0.002, p = 0.008, and p = 0.04, respectively). Concentrations were lower in the group of mothers who required oxytocin infusion for progression of labor. ROC analysis showed that all the mothers with dehydroepiandrosterone serum concentration above 21.6 nmol/L have lower chance to use oxytocin infusion for the labor progression ( area under the curve (AUC) = 0.649, sensitivity = 71.7%, specificity = 59.6%, p = 0.006). Conclusion This research provided reference ranges for the selected maternal serum steroid hormones at the beginning of parturition. Association of corticosterone, dehydroepiandrosterone, and androstenedione with the need for the oxytocin infusion usage has been established. Dehydroepiandrosterone could be potential predictor of oxytocin infusion augmentation for progression of the parturition.

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Section: Discussionsupporting

confidence: 92%

Requirement for oxytocin augmentation in spontaneous parturition is associated with the maternal serum steroid hormones assessed by liquid chromatography coupled to the tandem mass spectrometry

Kadivnik

Debeljak

Mandić

et al. 2021

J of Obstet and Gynaecol

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“…Finally, we utilized gold standard LC−MS/MS methods for hormone quantification which represent a considerable advance compared to prior methods with poor sensitivity for hormones such as androgens that are present at very low doses in adult women. 32 Extensive data collection from participating mothers and children allowed us to adjust for confounding and precision variables, which is an advance upon the many studies in this area that present only unadjusted models.…”

Section: Discussionmentioning

confidence: 99%

“…26,31 A final complication is that the standard radioimmunoassay techniques utilized by many studies may have inadequate sensitivity to accurately measure androgens present in extremely low concentrations, such as those observed in pregnant women. 32 Beyond digit ratio, alternative indirect measures of prenatal androgen exposure have been proposed, most notably anogenital distance (AGD), an anatomic measure from the anus to the genitals. Like digit ratio, AGD is readily measured with standard calipers.…”

Section: Introductionmentioning

confidence: 99%

Digit ratio, a proposed marker of the prenatal hormone environment, is not associated with prenatal sex steroids, anogenital distance, or gender-typed play behavior in preschool age children

Barrett

Thurston

Harrington

et al. 2020

J Dev Orig Health Dis

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Prenatal hormones have been proposed as key factors impacting child development as well as long-term health and disease. Digit ratio (the ratio of the lengths of the second to fourth digits; 2D:4D) has been proposed as a sexually dimorphic, noninvasive marker of prenatal androgen exposure that can be reliably measured in children and adults. To date, few longitudinal pregnancy cohort studies have examined childhood digit ratio in relation to other relevant measures including prenatal hormones and androgen-sensitive outcomes. To augment the current literature on this topic, we measured right-hand digit ratio in 4-year-old children participating in The Infant Development and the Environment Study, a multicenter longitudinal cohort study that has been following mother–child dyads since the first trimester of pregnancy (n = 321). We assessed sex differences in digit ratio and fit multivariable linear regression models to examine digit ratio in relation to: (1) child sex; (2) maternal sex steroid hormone concentrations in early pregnancy; (3) newborn anogenital distance, another proposed measure of sensitivity to prenatal androgens; and (4) gender-typical play behavior as measured by the Preschool Activities Inventory (PSAI) at age 4. We observed no sex difference in digit ratio; the mean 2D:4D was 0.97 ± 0.05 mm in both sexes. Furthermore, digit ratio was not associated with maternal sex steroid concentrations in early pregnancy, anogenital distance in either sex, or PSAI scores in either sex in covariate-adjusted models. In conclusion, we observed no evidence that early childhood digit ratio was associated with child sex or hormone-sensitive measures in this cohort.

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“…In pre-menopausal women, increased BMI is associated with anovulation, reducing lifetime exposure of circulating oestrogen and progesterone [44], thus lowering breast cancer risk [45] and increasing uterine cancer risk [46]. Higher maternal BMI is also associated with reduced oestrogen exposure in utero [47], which is protective against testicular cancer [48] and in males, elevated BMI reduces serum testosterone [49], reducing prostate cancer risk. Our findings of causal roles of BMI in regulating risk of certain reproductive and hormone-responsive cancers are therefore biologically plausible although the mechanistic links need to be assessed further.…”

Section: Discussionmentioning

confidence: 99%

Body size and composition and site-specific cancers in UK Biobank: a Mendelian randomisation study

Vithayathil

Carter

Kar

et al. 2020

Preprint

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word count: 299 Main text word count: 2,320 Number of Tables: 5 (supplementary) Number of Figures: 4 ABSTRACT Objectives To investigate the casual role of body mass index, body fat composition and height in cancer. DesignTwo stage mendelian randomisation study SettingPrevious genome wide association studies and the UK Biobank ParticipantsGenetic instrumental variables for body mass index (BMI), fat mass index (FMI), fat free mass index (FFMI) and height from previous genome wide association studies and UK Biobank .Cancer outcomes from 367 586 participants of European descent from the UK Biobank. Main outcome measuresOverall cancer risk and 22 site-specific cancers risk for genetic instrumental variables for BMI, FMI, FFMI and height. ResultsGenetically predicted BMI (per 1 kg/m 2 ) was not associated with overall cancer risk (OR 0.99; 95% confidence interval (CI) 0-98-1.00, p=0.105). Elevated BMI was associated with increased risk of stomach cancer (OR 1.15, 95% (CI) 1.05-1.26; p=0.003) and melanoma (OR 0.96, 95% CI 0.92-1.00; p=0.044). For sex-specific cancers, BMI was positively associated with uterine cancer (OR 1.08, 95% CI 1.01-1.14; p=0.015) but inversely associated with breast (OR 0.95, 95% CI 0.92-0.98; p=0.001), prostate (OR 0.95, 95% CI 0.92-0.99; p=0.007) and testicular cancer (OR 0.89, 95% CI 0.81-0.98; p=0.017). Elevated FMI (per 1 kg/m 2 ) was associated with gastrointestinal cancer (stomach cancer OR 4.23, 95% CI 1.18-15.13, p=0.027; colorectal cancer OR 1.94, 95% CI 1.23-3.07; p=0.004). Increased height (per 1 standard deviation, approximately 6.5cm) was associated with increased risk of overall cancer (OR 1.06; 95% 1.04-1.09; p = 2.9710 -8 ) and most site-specific cancers with the strongest estimates for kidney, non-Hodgkin lymphoma, colorectal, lung, melanoma and breast cancer. ConclusionsThere is little evidence for BMI as a casual risk factor for cancer. BMI may have a causal role for sexspecific cancers, although with inconsistent directions of effect, and FMI for gastrointestinal malignancies. Elevated height is a risk factor for overall cancer and multiple site cancers.

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Predictors of Steroid Hormone Concentrations in Early Pregnancy: Results from a Multi-Center Cohort

Abstract: Objectives: To identify factors predicting maternal sex steroid hormone concentrations in early pregnancy.

Cited by 24 publications

References 59 publications

Requirement for oxytocin augmentation in spontaneous parturition is associated with the maternal serum steroid hormones assessed by liquid chromatography coupled to the tandem mass spectrometry

Requirement for oxytocin augmentation in spontaneous parturition is associated with the maternal serum steroid hormones assessed by liquid chromatography coupled to the tandem mass spectrometry

Digit ratio, a proposed marker of the prenatal hormone environment, is not associated with prenatal sex steroids, anogenital distance, or gender-typed play behavior in preschool age children

Body size and composition and site-specific cancers in UK Biobank: a Mendelian randomisation study

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