Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus

Kupfer, Rosane; Larrúbia, Manuella Rangel; Bussade, Isabela; Pereira, Joana Rodrigues Dantas; Lima, Giovanna Aparecida Balarini; Epifanio, Marcio Antonio; Schettino, Claudio Domenico Sahione; Momesso, Denise

doi:10.1590/2359-3997000000255

Cited by 21 publications

(17 citation statements)

References 45 publications

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“…Carotid intima-media thickness (CIMT) is a well-established predictor for the risk of subclinical atherosclerosis [14]. Here, we found a positive correlation between serum miR-186-5p level and CIMT in atherosclerosis patients (r = 0.6634, p < 0.001; Fig.…”

Section: Correlation Of Mir-186-5p With Cimt In Atherosclerosis Patientssupporting

confidence: 52%

MicroRNA-186-5p serves as a diagnostic biomarker in atherosclerosis and regulates vascular smooth muscle cell proliferation and migration

et al. 2020

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Objective: MicroRNA dysregulation occurs in many human diseases, including atherosclerosis. Here, we examined the serum expression and clinical significance of miR-186-5p in patients with atherosclerosis, and explored its influence on vascular smooth muscle cell (VSMC) proliferation and migration. Methods: Blood samples were collected from 104 patients with asymptomatic atherosclerosis and 80 healthy controls. Quantitative real-time PCR was applied to measure the miR-186-5p level. An ROC curve was established to assess the discriminatory ability of the serum miR-186-5p level for identifying atherosclerosis from controls. CCK-8 and Transwell assays were used to evaluate the impact of miR-186-5p on cell behaviors. Results: Serum expression of miR-186-5p was significantly higher in atherosclerosis patients than in the control group. The serum miR-186-5p level showed a positive correlation with CIMT and could be used to distinguish atherosclerosis patients from healthy controls, with an area under the curve (AUC) score of 0.891. In VSMCs, overexpression of miR-186-5p significantly promoted cell proliferation and migration, while the opposite results were observed when miR-186-5p was downregulated. Conclusion: Overexpression of miR-186-5p has a certain diagnostic significance for atherosclerosis. Upregulation of miR-186-5p stimulates VSMC proliferation and migration. Therefore, it is a possible target for atherosclerosis interventions.

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Section: Correlation Of Mir-186-5p With Cimt In Atherosclerosis Patientssupporting

confidence: 52%

MicroRNA-186-5p serves as a diagnostic biomarker in atherosclerosis and regulates vascular smooth muscle cell proliferation and migration

et al. 2020

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“…A research looking at CVD risk trajectories from childhood to adulthood found that many of those who had consistently high BMIs during the life-course were better protected from carotid intima-media thickening if they were physically active 35 . Furthermore, in additional studies, no association was found between BMI and carotid atherosclerosis in non-diabetic 36 as well as diabetic patients 5,37 . We are not aware of any published evidence on the association of carotid elastography and…”

Section: Discussionmentioning

confidence: 86%

Long-Term Trajectories of BMI Predict Carotid Stiffness and Plaque Volume in Type 2 Diabetes Older Adults: a Cohort Study.

Moshe

Haratz

Ravona‐Springer

et al. 2020

Preprint

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Background: High body mass index (BMI) is a risk factor for type 2 diabetes and cardiovascular disease. However, its relationships with indices of carotid stiffness and plaque volume are unclear. We investigated associations of long-term measurements of BMI with indices of carotid stiffness and atherosclerosis among non-demented diabetes patients from the Israel Diabetes and Cognitive Decline (IDCD) study. Methods: Carotid ultrasound indices [carotid intima media thickness (cIMT), distensibility, elastography and plaque volume] were assessed in N=471 participants. Mean BMI across all MHS diabetes registry measurements and trajectories of BMI were calculated. BMI was categorized into three trajectory groups representing: a relatively stable normal weight (n=185, 44%), overweight trajectory (n=188, 44.8%) and a trajectory of obesity (n=47, 11.2%). Linear and logistic regressions estimated associations of carotid indices with mean BMI and BMI trajectories. Results: Compared to the normal weight trajectory, an obesity trajectory was associated with carotid distensibility (β=-3.078, p=0.037), cIMT (β=0.095, p=0.004), and carotid elastography (β=0.181, p=0.004) but not with plaque volume (β=0.066, p=0.858). Compared with the normal weight trajectory, an obesity trajectory was associated with increased odds for impaired carotid distensibility (OR=2.790, p=0.033), impaired cIMT (OR=5.277, p=0.001) and large carotid plaque volume (OR=8.456, p=0.013) but not with carotid elastography (OR=1.956, p=0.140). Mean BMI was linearly associated with Distensibility (β=-0.275, p=0.005) and cIMT (β=0.005, p=0.026).Conclusions: Long-term measurements of adiposity are associated with indices of carotid stiffness and plaque volume among older type 2 diabetes adults.

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“…[15][16][17]37,38 In the same line, one study has identified eGDR as a predictor of subclinical atherosclerosis, but it only included 45 women (mean age 36.2 ± 9.5 years). 19 In opposition, a recent study performed with 298 young individuals with T1D (mean (Figure 2), eGDR was the only IR marker which was associated with both the maximum height and presence of ≥2 plaques. Altogether, these findings suggest that IR assessed by eGDR could be a better marker of advanced atherosclerosis (plaque-related variables) rather than of its earlier stages (IMT-related variables) in this population.…”

Section: 405mentioning

confidence: 76%

“…Former studies evaluating IR as a predictor of increased carotid intima-media thickness (IMT) and/or carotid plaque presence are scarce. 18,19 Considering this background, our study aimed to test the association between IR, evaluated by both non-specific [metabolic syndrome (MetS) criteria according to the harmonized definition proposed by the main scientific societies in 2009 20 ] and specific (eGDR formula as a well-validated T1D-IR indicator 14 ) measures, and preclinical carotid atherosclerosis in a broad range of adults with T1D at high CVD risk.…”

Section: Introductionmentioning

confidence: 99%

Insulin resistance is associated with preclinical carotid atherosclerosis in patients with type 1 diabetes

Pané

Conget

Boswell

et al. 2020

Diabetes Metabolism Res

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Aim: Although insulin resistance (IR) is a growing trait among type 1 diabetes (T1D) population, its relationship with atherosclerosis has been scarcely studied. We assessed the association between IR indexes and carotid atherosclerosis in T1D, a population at high cardiovascular disease (CVD) risk. Materials and Methods: We evaluated 191 participants with T1D and no prior CVD with at least one of the following criteria: ≥40 years old; diabetic nephropathy; or T1D duration ≥10 years harbouring ≥1 additional CVD risk factor. IR was assessed with the metabolic syndrome (MetS) harmonized definition proposed in 2009 and the estimated glucose disposal rate (eGDR), a T1D-specific IR surrogate marker (lower values indicating higher IR). Standardized carotid ultrasonography was performed, recording intima-media thickness (IMT), plaque presence and maximum height of plaque. Comparisons between patients according to their MetS status as well as concerning eGDR values were performed. Results: The participants' median age was 47.4 (41.1-53.3) years and diabetes duration 25.7 (21.6-32.5) years. Plaque prevalence was higher in patients with greater IR (49.1%, 29.1% and 20%, P = .001, for any plaque according to decreasing eGDR tertiles). Conversely, no statistically significant higher plaque prevalence was found in participants with MetS. In multivariate analyses (adjusted for general-and T1Dspecific risk factors, and statin treatment), MetS was associated with neither IMT nor plaque. On the contrary, eGDR was independently related to ≥2 plaques (P = .018) and maximum plaque height (P < .01). Conclusions: In T1D, IR assessed through eGDR but not by MetS definition was independently associated with plaque burden, a predictor of CVD.

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Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus

Cited by 21 publications

References 45 publications

MicroRNA-186-5p serves as a diagnostic biomarker in atherosclerosis and regulates vascular smooth muscle cell proliferation and migration

MicroRNA-186-5p serves as a diagnostic biomarker in atherosclerosis and regulates vascular smooth muscle cell proliferation and migration

Long-Term Trajectories of BMI Predict Carotid Stiffness and Plaque Volume in Type 2 Diabetes Older Adults: a Cohort Study.

Insulin resistance is associated with preclinical carotid atherosclerosis in patients with type 1 diabetes

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