Predictors of subjective cognitive deficits in patients with mild cognitive impairment

Loessner, Lorenz; Matthes, Claudia; Haußmann, Robert; Brandt, Moritz; Sauer, Cathrin; Espin, Melanie; Noppes, Felix; Werner, Annett; Linn, Jennifer; Hummel, Thomas; Haehner, Antje; Donix, Markus

doi:10.1111/psyg.12802

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…Additionally, the entorhinal cortex is correlated with episodic memory and is impacted by Alzheimer's disease-related pathology [55]. The results reinforce studies that linked entorhinal cortex thickness to cognitive impairment [56][57][58].…”

Section: Discussionsupporting

confidence: 68%

Brodmann Areas, V1 Atlas and Cognitive Impairment: Assessing Cortical Thickness for Cognitive Impairment Diagnostics

Trišins,

Zdanovskis,

Platkājis

et al. 2024

Medicina

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Background and Objectives: Magnetic resonance imaging is vital for diagnosing cognitive decline. Brodmann areas (BA), distinct regions of the cerebral cortex categorized by cytoarchitectural variances, provide insights into cognitive function. This study aims to compare cortical thickness measurements across brain areas identified by BA mapping. We assessed these measurements among patients with and without cognitive impairment, and across groups categorized by cognitive performance levels using the Montreal Cognitive Assessment (MoCA) test. Materials and Methods: In this cross-sectional study, we included 64 patients who were divided in two ways: in two groups with (CI) or without (NCI) impaired cognitive function and in three groups with normal (NC), moderate (MPG) and low (LPG) cognitive performance according to MoCA scores. Scans with a 3T MRI scanner were carried out, and cortical thickness data was acquired using Freesurfer 7.2.0 software. Results: By analyzing differences between the NCI and CI groups cortical thickness of BA3a in left hemisphere (U = 241.000, p = 0.016), BA4a in right hemisphere (U = 269.000, p = 0.048) and BA28 in left hemisphere (U = 584.000, p = 0.005) showed significant differences. In the LPG, MPG and NC cortical thickness in BA3a in left hemisphere (H (2) = 6.268, p = 0.044), in V2 in right hemisphere (H (2) = 6.339, p = 0.042), in BA28 in left hemisphere (H (2) = 23.195, p < 0.001) and in BA28 in right hemisphere (H (2) = 10.015, p = 0.007) showed significant differences. Conclusions: Our study found that cortical thickness in specific Brodmann Areas—BA3a and BA28 in the left hemisphere, and BA4a in the right—differ significantly between NCI and CI groups. Significant differences were also observed in BA3a (left), V2 (right), and BA28 (both hemispheres) across LPG, MPG, NC groups. Despite a small sample size, these findings suggest cortical thickness measurements can serve as effective biomarkers for cognitive impairment diagnosis, warranting further validation with a larger cohort.

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Section: Discussionsupporting

confidence: 68%

Brodmann Areas, V1 Atlas and Cognitive Impairment: Assessing Cortical Thickness for Cognitive Impairment Diagnostics

Trišins,

Zdanovskis,

Platkājis

et al. 2024

Medicina

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“…We found 29 studies [ 38 , 82 - 109 ] on neuropsychiatric disorders with major memory impairments such as dementia, MCI, and vascular events while nine studies on memory deficits related to electroconvulsive therapy (ECT). [ 72 , 110 - 117 ] These details are shown in Supplementary Tables 3 and 4 , respectively.…”

Section: Resultsmentioning

confidence: 99%

Assessment of memory deficits in psychiatric disorders: A systematic literature review

Kushwaha,

Basera,

Kumari

et al. 2024

JNRP

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Memory deficits are observed across psychiatric disorders ranging from the prodrome of psychosis to common mental disorders such as anxiety, depression, and dissociative disorders. Memory deficits among patients recovering from psychiatric disorders could be directly related to the primary illness or secondary to the adverse effect of a treatment such as Electroconvulsive Therapy (ECT). The trouble in the meaningful integration of working-memory and episodic memory is the most commonly affected domain that requires routine assessments. An update on the recent trends of methods of assessment of memory deficits is the first step towards understanding and correcting these deficits to target optimum recovery. A systematic literature search was conducted from October 2018 to October 2022 to review the recent methods of assessment of memory deficits in psychiatric disorders. The definition of ‘Memory deficit’ was operationalized as ‘selective processes of memory, commonly required for activities of daily living, and affected among psychiatric disorders resulting in subjective distress and dysfunction’. We included 110 studies, most of them being conducted in western countries on patients with schizophrenia. Other disorders included dementia and mild cognitive impairment. Brief Assessment of Cognition in Schizophrenia, Cambridge Automated Neuropsychological Test Battery, California Verbal Learning Test, Trail Making Test Part A and B, Rey Auditory Verbal Learning Test, Wechsler Memory Scale, Wechsler Adults Intelligence Scale-IV were the most common neuropsychological assessments used. Mini-Mental State Examination and Montreal Cognitive Assessment were the most common bedside assessment tools used while Squire Subjective Memory Questionnaire was commonly used to measure ECT-related memory deficits. The review highlights the recent developments in the field of assessment of memory deficits in psychiatric disorders. Findings recommend and emphasize routine assessment of memory deficits among psychiatric disorders in developing countries especially severe mental illnesses. It remains interesting to see the role of standardized assessments in diagnostic systems given more than a decade of research on memory deficits in psychiatric disorders.

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Analysis of electric field strengths and focality for healthy and neurologically impaired subjects upon multiple tDCS stimulation protocols

Pancholi,

Dave

2023

Res. Biomed. Eng.

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Predictors of subjective cognitive deficits in patients with mild cognitive impairment

Cited by 4 publications

References 43 publications

Brodmann Areas, V1 Atlas and Cognitive Impairment: Assessing Cortical Thickness for Cognitive Impairment Diagnostics

Brodmann Areas, V1 Atlas and Cognitive Impairment: Assessing Cortical Thickness for Cognitive Impairment Diagnostics

Assessment of memory deficits in psychiatric disorders: A systematic literature review

Analysis of electric field strengths and focality for healthy and neurologically impaired subjects upon multiple tDCS stimulation protocols

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