Predictors of Subjective Cognitive Difficulties in Older Adults With Atherosclerotic Vascular Disease

Subjective Cognitive Complaints Relate to White Matter Hyperintensities and Future Cognitive Decline in Patients With Cardiovascular Disease

“…However, a systematic review of the clinical and community-based research suggests a significant interaction between the length of follow-up and the findings (38). Most cross-sectional and brief follow-up studies (< 6 months) tend to report no relationship between self-reported cognitive difficulties and objective measures of cognition (8–10, 17, 19, 20), while the majority of longer follow-ups (2 – 8 years) reveal a significant relationship between subjective memory complaints and objectively measured cognitive decline even after adjustment for depressive symptoms (1, 2, 4–6). Consistent with this review, we previously observed modest cross-sectional relationships between reported cognitive difficulties and cognition, yet depressive symptoms were moderately related to cognitive complaints (20).…”

“…It has been used in both healthy and patient samples, including persons with CVD (17, 19, 20, 31, 35). Participants are asked to rate themselves using a 5-point Likert scale (from “never” to “most of the time”) on several statements describing everyday inefficiencies (e.g., “I find it hard to keep my mind on a task or a job.”), lapses of memory (e.g., “I have trouble recalling frequently used phone numbers”), and related functions that people often notice about themselves (e.g., “I have to do things very slowly to be sure I’m doing them right.”).…”

Cognitive Function Does Not Impact Self-reported Health-Related Quality of Life in Heart Failure Patients

“…In addition, reduced QoL was a contributor [44]. Similarly, Humphreys et al [45] reported that the relationship between neuropsychological assessment and self-reported cognitive functioning was attenuated after adjusting for psychological distress in adults with atherosclerotic vascular disease. Although some prior research on the topic is mixed, a recent large, community-based sample also found that depressive symptoms were related to subjective cognitive complaints after controlling for demographic and psychosocial variables, whereas no relationship between subjective cognitive complaints and an objective measurement emerged following adjustment for covariates [46].…”

Lack of awareness of neuropsychological deficit in cerebral small vessel disease: The relationship with executive and episodic memory functions

“…Previous research into awareness of neuropsychological deficits in patient with widespread cerebrovascular pathology has shown varied results (Humphreys et al ., 2007; Starkstein et al ., 1997). This may be partly due to the heterogeneity of clinical entities within mixed vascular groups, with different degrees of neuropsychological decline.…”

“…This is perhaps due to the heterogeneity of the populations examined; vascular neuropsychological impairment can result from heterogeneous pathologies including multiple large cortical infarcts and single strategic infarcts, as well as SVD. Previous studies have often not differentiated between the different pathologies (Humphreys, Moser, Hynes, Reese, & Haynes, 2007; Starkstein et al ., 1997). In practice, differentiation of diagnostic entities can be difficult and many patients with vascular neuropsychological impairment have additional Alzheimer's pathology (Erkinjuntti & Rockwood, 2003).…”