Predictors of subjective health status 10 years post-PCI

Berge, J; Dulfer, Karolijn; Utens, Elisabeth M. W. J.; Hartman, Eline M J; Daemen, Joost; Geuns, Robert Jan van; Domburg, Ron T. van

doi:10.1016/j.ijcha.2016.03.011

Cited by 4 publications

(5 citation statements)

References 43 publications

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“…At the 3-year follow-up after PCI, the significant independent determinants of a lower QoL included the female sex, age >60 years and diabetes mellitus [ 16 ]. According to van den Berge et al, [ 42 ] studies including a 12-month follow-up have shown that age, the male gender, renal impairment, smoking and prior coronary artery bypass grafting were predictors of health status post-PCI. At 10 years post-PCI, the SF-36 scores at baseline, age and previous PCI were significant predictors of subjective health status.…”

Section: Discussionmentioning

confidence: 99%

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Quality of Life in Patients Undergoing Percutaneous Coronary Intervention

Tsoulou

Vasilopoulos

Kapadohos

et al. 2023

Clinics and Practice

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Introduction: Percutaneous coronary intervention (PCI) is a non-surgical invasive procedure to treat coronary artery occlusion. The quality of life (QoL) is a way to measure the impact of illness and additionally its treatments to traditional measures of clinical outcomes. Purpose: The aim of the present study was to explore the levels of QoL pre-PCI, 6 and 12 months after PCI, as well as the factors associated with the QoL pre-PCI. Methods: In the present study, 100 patients undergoing PCI were enrolled. Data were collected through the completion of the SF-36 Health Survey (SF-36), which included participants’ characteristics. The statistical significance level was p < 0.05. Results: Patients had moderate levels of QoL at baseline, with a median general health score of 45 (IQR: 30–65). A gradual statistically significant increase in scores was observed in all subcategories of the patients’ QoL at 6 and 12 months after PCI (p < 0.001). A greater increase in scores was observed in physical functioning, physical role, emotional role and social functionality. In terms of the pre-PCI phase, it was found that physical functionality was statistically significantly associated with educational level (p = 0.005), occupation (p = 0.026) and whether the patients had children (p = 0.041). The physical and emotional role was significantly associated with gender (p = 0.046 and p = 0.040) and educational level (p = 0.030 and p = 0.001). Energy–fatigue was significantly associated with gender (p = 0.001), age (p = 0.028), marital status (p = 0.001), educational level (p = 0.001), whether the patients had children (p= 0.012) and other diseases (p = 0.001). Emotional well-being was significantly associated with family history of coronary artery disease (p = 0.011) and the frequency of physical exercise (p = 0.001). Social functioning was significantly associated with gender (p = 0.033), marital status (p = 0.034) and educational level (p = 0.002). Pain was not found to be significantly associated with patients’ demographics. General health was significantly associated with gender (p = 0.003), age (p = 0.043), educational level (p = 0.001), other diseases (p = 0.005) and the frequency of physical exercise (p = 0.001). Conclusion: Information about the QoL of PCI and its determinants is important to define an effective and comprehensive care plan.

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Section: Discussionmentioning

confidence: 99%

“…At 10 years post-PCI, the SF-36 scores at baseline, age and previous PCI were significant predictors of subjective health status. Evaluating the QoL at baseline is a useful indicator to predict the long-term subjective health status [ 42 ]. Modification of the SF-36 score is a key challenge for clinicians involved in the care of PCI.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life in Patients Undergoing Percutaneous Coronary Intervention

Tsoulou

Vasilopoulos

Kapadohos

et al. 2023

Clinics and Practice

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“…По данным J.C. Van den Berge и соавт., которые опросили 1055 больных ИБС с помощью опросника SF-36 через 6 мес. после чрескожной транслюминальной коронарной ангиопластики, пожилой возраст и предшествующая реваскуляризация миокарда негативно влияют на физические и ментальные параметры качества жизни [21]. В нашей работе у пациентов, перенесших ОКС, чрескожная транслюминальная коронарная ангиопластика в анам-незе повлияла только на психологический аспект здоровья в отдаленном периоде после реваскуляризации миокарда.…”

Section: Discussionunclassified

Quality of life after myocardial re-vascularisation in patients with acute coronary syndrome during the coronavirus disease 2019 pandemic: a prospective observational study

Клинкова¹,

Kamenskaya²,

Логинова³

et al. 2021

PKiK

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Aim. To study the quality of life and how it is influenced by different factors in the long term after myocardial re-vascularisation in patients with coronary artery disease who had acute coronary syndrome during the coronavirus disease 2019 (COVID-19) pandemic.Methods. We examined 658 patients with coronary artery disease and acute coronary syndrome (mean age 66.4 ± 4.3 years). Percutaneous coronary intervention (600 patients) and coronary artery bypass grafting with cardio-pulmonary bypass (58 patients) were performed. Six months after myocardial re-vascularisation, we assessed patients' quality of life using the SF-36 questionnaire. We identified factors that affect the quality of life using multivariate regression analysis.Results. After myocardial revascularisation, the patients had a reduced overall indicator of physical health (< 40 points). The overall indicator of psycho-emotional health was higher than physical (p < 0.002) but did not exceed 50 points. We noted the adverse effect of COVID-19 (regardless of disease severity) on the assessment. Also, COVID-19 was associated with increased anxiety. A history of concomitant diabetes mellitus, obesity, stroke and percutaneous coronary intervention had a negative effect on the overall indicators of physical and mental health.Conclusion. Patients with coronary artery disease who had acute coronary syndrome after myocardial re-vascularisation are characterised by reduced indicators of physical and average indicators of mental health in the long term. COVID-19, regardless of disease severity, has a negative impact on patients' general state of health, social activity and emotional background. A history of diabetes mellitus, obesity, stroke and percutaneous coronary intervention adversely affects the physical and mental health indicators.Received 4 August 2021. Revised 31 August 2021. Accepted 1 September 2021.Funding: This work was carried out within the framework of the state task of the Ministry of Health of the Russian Federation (No. 121031300225-8).Conflict of interest: Authors declare no conflict of interest.Contribution of the authors Conception and study design: O.V. Kamenskaya, V.V. Lomivorotov Data collection and analysis: A.S. Klinkova Statistical analysis: A.S. Klinkova Drafting the article: A.S. Klinkova, I.Yu. Loginova Critical revision of the article: O.V. Kamenskaya, A.M. Chernyavskiy Final approval of the version to be published: A.S. Klinkova, O.V. Kamenskaya, I.Yu. Loginova, A.M. Chernyavskiy, V.V. Lomivorotov

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“…Restenosis (RS) is an important factor restricting the long-term development of PCI [2,3]. The pathological pro-cess of restenosis involves many factors and multiple pathways; still, the exact mechanism remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Aralia armata (Wall.) Seem Improves Intimal Hyperplasia after Vascular Injury by Downregulating the Wnt3α/Dvl‐1/β‐Catenin Pathway

Zhao¹,

Huang

et al. 2021

BioMed Research International

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The aim of the study is to examine the mechanism of Aralia armata (Wall.) Seem (AAS) in improving intimal hyperplasia after vascular injury in rats. Rats with femoral artery injury were randomly divided into three groups: the model group, AAS low-dose group (40 mg/kg), and AAS high-dose group (80 mg/kg). The sham operation group was used as a control group. HE staining was used to observe the changes in femoral artery vessels. Immunohistochemistry was adopted to detect α-SMA, PCNA, GSK-3β, and β-catenin proteins in femoral artery tissue. The CCK-8 test and wound healing assay were employed to analyze the effect of AAS on proliferation and migration of vascular smooth muscle cells (VSMCs) cultured in vitro. Western blotting (WB) and polymerase chain reaction (PCR) assays were used to evaluate the molecular mechanism. AAS reduced the stenosis of blood vessels and the protein expressions of α-SMA, PCNA, GSK-3β, and β-catenin compared to the model group. In addition, AAS (0-15 μg/mL) effectively inhibited the proliferation and migration of VSMCs. Moreover, the results of WB and PCR showed that AAS could inhibit the activation of β-catenin induced by 15% FBS and significantly decrease the expression levels of Wnt3α, Dvl-1, GSK-3β, β-catenin, and cyclin D1 in the upstream and downstream of the pathway. AAS could effectively inhibit the proliferation and migration of neointima after vascular injury in rats by regulating the Wnt/β-catenin signaling pathway.

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Predictors of subjective health status 10 years post-PCI

Cited by 4 publications

References 43 publications

Quality of Life in Patients Undergoing Percutaneous Coronary Intervention

Quality of Life in Patients Undergoing Percutaneous Coronary Intervention

Quality of life after myocardial re-vascularisation in patients with acute coronary syndrome during the coronavirus disease 2019 pandemic: a prospective observational study

Aralia armata (Wall.) Seem Improves Intimal Hyperplasia after Vascular Injury by Downregulating the Wnt3α/Dvl‐1/β‐Catenin Pathway

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