“…However, there is considerable co-linearity between symptoms of anxiety and depression [217,265,266], and several investigations show both to be associated with pain, sleep disturbances, symptom severity, poorer perceived health, worse physical function, decreased vitality, and impaired social function [217,234,265,266,268]. In yet another investigation, both depression and anxiety scores correlated with the sensory and affective components of the MPQ and with pain intensity, but in regression analyses, only the physiological component of anxiety together with helplessness and fear of pain predicted the various aspects of pain, whereas depression was an important component in predicting self-efficacy for pain management and coping with symptoms [89]. Similarly, the presence of PTSD in FMS patients is associated with more severe symptoms (more pain, tenderness, and distress, and greater functional impairment) [245, 247], while FMS has a similar effect on PTSD [248, 249], although that is not an entirely consistent finding [244].…”