Predictors of Third Trimester Blood Trihalomethanes and Urinary Trichloroacetic Acid Concentrations among Pregnant Women

Zeng, Qiang; Cao, Wencheng; Zhou, Bin; Pan, Yang; Wang, Yi‐Xin; Huang, Zhen; Jin, Li; Lu, Wen-Qing

doi:10.1021/acs.est.5b05971

Cited by 22 publications

(6 citation statements)

References 57 publications

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“…Second, we included geographic residence setting (urban vs rural) and household income (<3000, 3000–4999, or ≥5000 Yuan/month) as additional covariates in the mixed regression models to evaluate the influence of maternal socioeconomic status. Third, to assess the influence of recent peak exposure events, we adjusted for the time interval since last showering or bathing due to their strong influence on THM concentrations. , Fourth, we included a different set of covariates in the final models based on the previous literature according to the directed acyclic graph (DAG): , maternal age (continuous), BMI at enrollment (continuous), geographic residence setting (urban vs rural), household income (<3000, 3000–4999, or ≥5000), and maternal education level (junior school and below, high school, or college and above) (Figure S2). Fifth, to assess the influence of maternal nutritional status, we included maternal weight gain during pregnancy (continuous) as a covariate in the mixed models.…”

Section: Methodsmentioning

confidence: 99%

Prenatal Exposure to Disinfection Byproducts and Intrauterine Growth in a Chinese Cohort

Liu

Sun

Mustieles

et al. 2021

Environ. Sci. Technol.

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Disinfection byproduct (DBP) exposure has been associated with birth size, pregnancy oxidative stress, and other adverse perinatal outcomes. However, little is known about the potential effect of prenatal DBP exposure on intrauterine growth. The present study included 1516 pregnant women from the Xiaogan Disinfection By-Products (XGDBP) birth cohort who were measured for four blood trihalomethanes [i.e., chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM)] and two urinary haloacetic acids [i.e., dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA)] across pregnancy trimesters. Second-and third-trimester fetal ultrasound measures of the abdominal circumference (AC), head circumference, biparietal diameter, femur length, and estimated fetal weight and birth weight were converted into z-scores. After adjusting for potential confounders, linear mixed models showed a decreasing AC z-score across tertiles of blood brominated THM (Br-THMs, the sum of BDCM, DBCM, and TBM) and total THM (THM4, the sum of Br-THMs and TCM) concentrations (both p for trend <0.01). We also observed a decreasing AC z-score across categories of blood TBM during pregnancy trimesters (p for trend = 0.03). Urinary haloacetic acids were unrelated to fetal growth parameters. In summary, prenatal exposure to THMs, particularly during the first trimester, was associated with reduced fetal abdominal circumference.

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Section: Methodsmentioning

confidence: 99%

Prenatal Exposure to Disinfection Byproducts and Intrauterine Growth in a Chinese Cohort

Liu

Sun

Mustieles

et al. 2021

Environ. Sci. Technol.

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“…As numerous human epidemiological studies have already demonstrated the correlation between DBP exposure and several human health impacts, including bladder cancer, birth defects, and fetal loss, − CHO cells that have been frequently used in DBP toxicity study were selected in the present study to comparatively assess the in vitro toxicity of bromophenols. CHO-K1 cell line acquired from the American Type Culture Collection was used in the present study to comparatively evaluate the cytotoxicity of 4-BrPh and 2,4-DiBrPh.…”

Section: Methodsmentioning

confidence: 99%

“…Disinfection byproducts (DBPs) are a group of chemical substances unintentionally generated from the reactions of disinfectants with organic matter (mainly including natural organic matter, effluent organic matter, and emerging environmental contaminants) during the water disinfection process. − They have generally been considered as one important series of food contaminants owing to their diversity and daily long-term exposure to human beings through ingestion of disinfected drinking water, beverages prepared with tap water (e.g., coffee, tea, and juices) or foods treated using disinfected water (e.g., washed vegetables and fruits). , Previous studies with different types of toxicity bioassays reported that many DBPs were potential cytotoxicants, genotoxicants, mutagens, neurotoxicants, carcinogens, and/or teratogens, − despite the fact that their toxic mechanisms are not fully understood currently. Moreover, human epidemiological studies provided evidence of an association between DBP exposure and adverse birth outcomes/raised health risks of cancers (colorectal and bladder). − Hence, due to the ubiquitous existence of DBPs in disinfected potable water, there is an increasing concern on the adverse effects of DBPs on human health.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Insights into the Interactions of Two Emerging Bromophenolic DBPs with Human Serum Albumin by Multispectroscopy and Molecular Docking

Zhang

Yang

et al. 2019

ACS Omega

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Disinfection byproducts (DBPs) are of high concern due to their ubiquitous existence in disinfected drinking water and their potential adverse effects on human health. In this study, two bromophenolic DBPs 4-bromophenol (4-BrPh) and 2,4-dibromophenol (2,4-DiBrPh) were selected to investigate their binding interactions with human serum albumin (HSA) using spectroscopic techniques and a molecular docking method. The experimental results demonstrated that both of the DBPs could bind with HSA to form bromophenol–HSA complexes with the HSA secondary structure being changed, primarily relying on hydrogen bonding and van der Waals forces, but 2,4-DiBrPh showed a higher binding affinity. The binding constants of 4-BrPh–HSA and 2,4-DiBrPh–HSA were 2.66 × 103 and 1.83 × 104 M–1 at 310 K, respectively. Molecular docking results revealed the locations of the binding sites for bromophenols on HSA (locating in subdomain IB). In addition, the comparative toxicity of the two bromophenolic DBPs was evaluated with the mammalian cytotoxicity bioassay and the results showed that the LC50 values of 4-BrPh and 2,4-DiBrPh were 3.08 × 10–5 and 1.09 × 10–5 M, respectively. Notably, 2,4-DiBrPh with a higher binding affinity toward HSA also showed a significantly higher toxic potency than 4-BrPh.

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“…12,13 However, existing studies on the health effects of maternal exposure to PCPCs are inconclusive because of their rapid elimination (<24 h) and high within-person variability. 14−16 Considering the changes of physiological, metabolic, and behavioral factors during pregnancy, 17 understanding variations and determinants of exposure to those contemporary-use chemicals at multiple time points is a critical step in exploring their adverse health effects on mothers and fetuses.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The detections of the above chemicals in cord serum, milk samples, placental tissues, and amniotic fluid indicate the transfer of these compounds from mothers to fetuses. Recently, epidemiological reports have suggested that exposure to PCPCs during pregnancy could cause pregnancy complications , and adverse birth outcomes. , However, existing studies on the health effects of maternal exposure to PCPCs are inconclusive because of their rapid elimination (<24 h) and high within-person variability. − Considering the changes of physiological, metabolic, and behavioral factors during pregnancy, understanding variations and determinants of exposure to those contemporary-use chemicals at multiple time points is a critical step in exploring their adverse health effects on mothers and fetuses.…”

Section: Introductionmentioning

confidence: 99%

Variations, Determinants, and Coexposure Patterns of Personal Care Product Chemicals among Chinese Pregnant Women: A Longitudinal Study

Liu

Xia

et al. 2019

Environ. Sci. Technol.

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Exposure to mixtures of personal care product chemicals (PCPCs) is commonplace among the Chinese population; yet, limited data are available on the variations, determinants, and coexposure patterns of PCPCs, particularly among pregnant women at multiple time points during gestation. Here, we measured concentrations of 11 most common PCPCs (five parabens, five benzophenones, and triclosan) in 2823 urine samples collected from 941 pregnant women over three trimesters. Based on the quantification results, we calculated the intraclass correlation coefficient (ICC) to assess within-person variability of targeted compounds, applied linear mixed mode models to explore associations between urinary concentrations of PCPCs and exposure-related factors, and used percentile analysis to evaluate exposure to specific or multiple chemicals at one or three trimesters. Seven targeted compounds: methylparaben (MeP), ethylparaben (EtP), propylparaben (PrP), 4-hydroxybenzophenone (4-OH-BP), 2,4-dihydroxybenzophenone (BP-1), 2-hydroxy-4-methoxybenzophenone (BP-3), and triclosan (TCS) were detected in over 66% of samples. The median urinary concentrations (ng/mL) of MeP, EtP, PrP, 4-OH-BP, BP-1, BP-3, and TCS were 15.44, 0.49, 0.61, 0.16, 0.25, 0.53, and 0.48, respectively. We observed that benzophenones (ICC: 0.46–0.55) and triclosan (ICC: 0.50) were less variable than parabens (ICC: 0.35–0.40). Urinary levels of parabens were related to physical activity frequency; urinary levels of benzophenones were associated with the refurbishment of homes and household income, and urinary levels of triclosan were contingent upon the personal basic information (prepregnancy body mass index and age). Notably, higher levels of benzophenones and triclosan but lower paraben levels were observed in summer than in winter. Both coexposure to high percentiles of multiple pollutants at one trimester and exposure to one pollutant at high-dose through three trimesters were rare in the study population. Our findings suggest that these exposure-related factors should be taken into consideration, and health risks should be assessed on mixtures of pollutants in future epidemiological studies.

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Predictors of Third Trimester Blood Trihalomethanes and Urinary Trichloroacetic Acid Concentrations among Pregnant Women

Cited by 22 publications

References 57 publications

Prenatal Exposure to Disinfection Byproducts and Intrauterine Growth in a Chinese Cohort

Prenatal Exposure to Disinfection Byproducts and Intrauterine Growth in a Chinese Cohort

Comprehensive Insights into the Interactions of Two Emerging Bromophenolic DBPs with Human Serum Albumin by Multispectroscopy and Molecular Docking

Variations, Determinants, and Coexposure Patterns of Personal Care Product Chemicals among Chinese Pregnant Women: A Longitudinal Study

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