Predictors of two-year mortality in Asian patients with heart failure and preserved ejection fraction

Yap, Jonathan; Sim, David; Lim, Choon Pin; Chia, Stanley; Go, Yun Yun; Jaufeerally, Fazlur; Sim, Ling Ling; Liew, Reginald; Ching, Chi Bun

doi:10.1016/j.ijcard.2015.01.063

Cited by 30 publications

(21 citation statements)

References 39 publications

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“…Nevertheless, a recent report from Singapore showed similar findings regarding in-hospital death (1.2%). 37 In terms of long-term clinical outcomes, our study revealed that HFpEF in Japanese is not always a benign entity, having a 2-year mortality rate of 20.9%. The JCARE-CARD registry reported a similar mortality of approximately 19% after a mean follow-up of 2.4 years.…”

Section: Long-term Clinical Outcomes and Mode Of Deathmentioning

confidence: 73%

“…7 The 2-year all-cause mortality rate of Singapore hospitalized patients with HFpEF was higher at 26.6%. 37 Despite the differences in the studies, mortality rates remain high in Asian HFpEF patients. On the other hand, around half of hospitalized US HFpEF patients registered to GWTG-HF died during the 2 years after admission.…”

Section: Long-term Clinical Outcomes and Mode Of Deathmentioning

confidence: 99%

“…40 Pathophysiologically, severe hypoalbuminemia accelerates fluid retention and systemic edema through a decline in plasma oncotic pressure, which may result in further progression of cardiac and renal impairment accompanied by diuretic resistance in HF patients. 41 Importantly, the determinants of clinical outcome differ between HFpEF and HFrEF, 37 and hypoalbuminemia would be an important strong prognostic determinant in HFpEF patients especially. 42, 43 These reports support our findings, and serum albumin could be an important nutritional marker.…”

Section: Supplementary Informationmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Characteristics, Management, and Outcomes of Japanese Patients Hospitalized for Heart Failure With Preserved Ejection Fraction　― A Report From the Japanese Heart Failure Syndrome With Preserved Ejection Fraction (JASPER) Registry ―

Nagai

Yoshikawa

Saito

et al. 2018

Circ J

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Section: Long-term Clinical Outcomes and Mode Of Deathmentioning

confidence: 73%

Section: Long-term Clinical Outcomes and Mode Of Deathmentioning

confidence: 99%

Section: Supplementary Informationmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Characteristics, Management, and Outcomes of Japanese Patients Hospitalized for Heart Failure With Preserved Ejection Fraction　― A Report From the Japanese Heart Failure Syndrome With Preserved Ejection Fraction (JASPER) Registry ―

Nagai

Yoshikawa

Saito

et al. 2018

Circ J

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“…4,9,10 Most recently, the 2-year mortality in 751 patients with HFpEF from Singapore was found to be 26.6% (compared with 37.1% in patients with reduced ejection fraction [HR 0.618; 95% CI 0.508-0.753]), with no ethnic differences. Currently, very little is known regarding the prevalence and outcome of patients with HFpEF from Southeast Asia.…”

Section: Heart Failure With Preserved Ejection Fraction In Southeast mentioning

confidence: 99%

Heart failure in Southeast Asia: facts and numbers

Lam

2015

ESC Heart Failure

116

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Southeast Asia is home to a growing population of >600 million people, the majority younger than 65 years, but among whom, rapid epidemiological transition has led to high rates of premature death from non-communicable diseases (chiefly cardiovascular disease) (up to 28% in the Philippines vs. 12% in UK). There is a strikingly high prevalence of stage A heart failure (HF) risk factors in Southeast Asia, particularly hypertension (>24% in Cambodia and Laos vs. 13-15% in UK and USA), tobacco smoking (>36% in Indonesia), physical inactivity (>50% in Malaysia) and raised blood glucose (10-11% in Brunei, Malaysia, Singapore and Thailand) in spite of a low prevalence of overweight/obesity (21-26% in Southeast Asia vs. 67-70% in UK and USA). Accordingly, the prevalence of symptomatic HF appears to be higher in Southeast Asian countries compared with the rest of the world. Epidemiologic trends in Singapore showed a sharp 38% increase in age-adjusted HF hospitalizations (from 85.4 per 10 000 in 1991 to 110.3 per 10 000 in 1998) with notable ethnic differences (hospitalization rates ~35% higher in Malays and Indians vs. Chinese; mortality 3.5 times higher in Malays vs. Indians and Chinese). Furthermore, Southeast Asian patients present with acute HF at a younger age (54 years) compared with USA patients (75 years) but have more severe clinical features, higher rates of mechanical ventilation, longer lengths of stay (6 vs. 4.2 days) and higher in-hospital mortality (4.8 vs. 3.0%). Finally, there is under-usage of guideline-recommended HF medical therapies (prescribed in 31-63% of patients upon discharge) and device therapies in Southeast Asia. Large gaps in knowledge that need to be addressed in Southeast Asia include the prevalence of HF with preserved ejection fraction, clinical outcomes, barriers to recommended therapies and their cost-effectiveness, as well as possible ethnicity-specific pathophysiologic mechanisms.

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“…The 2-year mortality is up to 26.6% in Asians complicating HFpEF. [ 1 ] Acute myocardial infarction (AMI) is one of the main causes of morbidity and in-hospital mortality worldwide, although the increasing use of early myocardial reperfusion and medical treatments have contributed significantly to the decline in mortality. [ 2 – 4 ] In AMI patients, the presence of HFpEF might worsen the prognosis, and the incident adverse events increase due to the therapeutic limitations.…”

Section: Introductionmentioning

confidence: 99%

Predictors and prognosis for incident in-hospital heart failure in patients with preserved ejection fraction after first acute myocardial infarction

Liu²,

Xu³

et al. 2018

Medicine

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Patients with acute myocardial infarction (AMI) complicated by heart failure with preserved ejection fraction (HFpEF) are likely to have more adverse cardiovascular events and higher mortality. The purpose of this study was to examine the predictors and outcomes in AMI patients complicated by HFpEF.We examined the demographics, clinical data, and clinical outcomes in 405 consecutive subjects who firstly presented with AMI after undergoing emergency percutaneous coronary intervention from January 2013 to June 2016.Three hundred twenty patients and eighty-five patients were classified into the nonheart failure (non-HF) group and HFpEF group, respectively. Patients with HFpEF had higher prevalence of prior hypertension, had higher levels of biomarkers, and had a larger left atrial diameter with a nondilated left ventricle were more likely to develop multivessel disease-vessels and had infarction-related artery located in left anterior descending artery than patients without HF. Moreover, patients with HFpEF had a higher probability of developing the in-hospital incident cardiovascular complications and death than non-HF patients.Two routine biomarkers, levels of hypersensitive C-reactive protein and N-terminal-pro brain natriuretic peptide, and number of diseased-vessels were independent predictors for in-hospital HFpEF incidence in AMI patients with preserved LVEF. AMI patients with HFpEF had a higher probability of in-hospital cardiovascular outcomes and mortality.

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Predictors of two-year mortality in Asian patients with heart failure and preserved ejection fraction

Cited by 30 publications

References 39 publications

Clinical Characteristics, Management, and Outcomes of Japanese Patients Hospitalized for Heart Failure With Preserved Ejection Fraction　― A Report From the Japanese Heart Failure Syndrome With Preserved Ejection Fraction (JASPER) Registry ―

Clinical Characteristics, Management, and Outcomes of Japanese Patients Hospitalized for Heart Failure With Preserved Ejection Fraction　― A Report From the Japanese Heart Failure Syndrome With Preserved Ejection Fraction (JASPER) Registry ―

Heart failure in Southeast Asia: facts and numbers

Predictors and prognosis for incident in-hospital heart failure in patients with preserved ejection fraction after first acute myocardial infarction

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Predictors of two-year mortality in Asian patients with heart failure and preserved ejection fraction

Cited by 30 publications

References 39 publications

Clinical Characteristics, Management, and Outcomes of Japanese Patients Hospitalized for Heart Failure With Preserved Ejection Fraction ― A Report From the Japanese Heart Failure Syndrome With Preserved Ejection Fraction (JASPER) Registry ―

Clinical Characteristics, Management, and Outcomes of Japanese Patients Hospitalized for Heart Failure With Preserved Ejection Fraction ― A Report From the Japanese Heart Failure Syndrome With Preserved Ejection Fraction (JASPER) Registry ―

Heart failure in Southeast Asia: facts and numbers

Predictors and prognosis for incident in-hospital heart failure in patients with preserved ejection fraction after first acute myocardial infarction

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Product

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Clinical Characteristics, Management, and Outcomes of Japanese Patients Hospitalized for Heart Failure With Preserved Ejection Fraction　― A Report From the Japanese Heart Failure Syndrome With Preserved Ejection Fraction (JASPER) Registry ―

Clinical Characteristics, Management, and Outcomes of Japanese Patients Hospitalized for Heart Failure With Preserved Ejection Fraction　― A Report From the Japanese Heart Failure Syndrome With Preserved Ejection Fraction (JASPER) Registry ―