Predictors of Unfavorable Cource of Papillary Thyroid Carcinoma

Abstract

Determination of risk factors for metastasis and aggressive course of PTC is important in determining the scope of surgical treatment, namely the need for lymph node dissection in patients with this cancer.Aim -to review the professional medical literature to determine the factors of unfavorable course of papillary thyroid carcinoma.According to the results of studies, size of tumor larger than 1.0 cm and multifocal lesions can be considered an indicator of the aggressive course of PTC. AIT complicates the cytological diagnosis of nodal masses. A definite causeand-effect relationship between AIT and PTC remains unclear. The basis for this relationship is the molecular, hormonal and histopathological similarity of these diseases. Galectin-3 is a regulator of normal cell proliferation, and its overexpression leads to malignant cell transformation and metastasis. The neoplastic transformation of benign