Predictors of Vitamin B6 and Folate Concentrations in Older Persons: The InCHIANTI Study

Abstract

Background: Low dietary intake and low serum concentrations of vitamin B 6 and/or folate are associated with increased risk of vascular events, possibly because of their association with inflammation, which plays a crucial role in the pathogenesis of cardiovascular diseases. Methods: Using data from 1320 participants in the population-based InCHIANTI study (586 men and 734 women; median age, 69 years; range, 21-102 years) for whom complete data on folate, vitamin B 6 , inflammatory markers, 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T sequence variant, and important covariates were available, we evaluated the association of inflammatory markers with circulating concentrations of vitamin B 6 and folate, independently of dietary vitamin intake, circulating vitamin concentrations, and MTHFR C677T sequence variant. Results: According to multiple linear regression analysis, C-reactive protein and interleukin-6 receptor were strongly and negatively associated with circulating vitamin B 6 but not with folate concentrations, independent of age, sex, serum creatinine, serum albumin, total energy intake, smoking history, dietary nutrient intake,

Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis

“…To eliminate the interference of folic acid, we co-intervened folic acid in this study. As was found in earlier studies (Gori et al, 2006), serum folate concentration was not associated with hs-CRP and IL-6 in our RA patients (data not shown). Beyond serum folate, plasma PLP seems to have a major role in the regulation of inflammatory response in patients with RA.…”

“…As plasma PLP acts as a co-enzyme for the production of cytokines and other polypeptide mediators during the inflammatory response (Friso et al, 2001), a prolonged pro-inflammatory state may lead to plasma PLP depletion and could be expected to be inversely associated with pro-inflammatory cytokines (that is, IL-6 or TNF-a) in patients with RA. Plasma PLP levels have been shown to be inversely correlated with production of TNF-a by peripheral blood mononuclear cells from patients with RA (Roubenoff et al, 1995) and with IL-6 receptor (Gori et al, 2006). Thus, supplementation of vitamin B6 may be expected to result in decreased IL-6 or TNF-a levels in RA patients.…”

A Cross-Sectional Study to Find Out the Relationship of Methylenetetrahydrofolate Reductase (MTHFR) C677T Genotype with Plasma Levels of Folate and Total Homocysteine by Daily Folate Intake in Japanese

“…However, folate intake could increase blood folate levels even among those with the TT genotype. In previous observational studies, decreased tHcy levels were related to increased blood folate levels (8)(9)(10)(11), and increased folate intake was associated with increased blood folate levels (8,12) and decreased tHcy levels (8,13,14) in each of the MTHFR genotype. These correlations were substantially stronger among those with TT (8,9,(11)(12)(13)(14)(15) and those consuming relatively lower amounts of folate (8,12,13).…”

“…In previous observational studies, decreased tHcy levels were related to increased blood folate levels (8-11), and increased folate intake was associated with increased blood folate levels (8, 12) and decreased tHcy levels (8,13,14) in each of the MTHFR genotype. These correlations were substantially stronger among those with TT (8,9,[11][12][13][14][15] and those consuming relatively lower amounts of folate (8,12,13). In previous interventional studies using folate supplements or fortified foods, increased folate intake raised blood folate (16-21) and reduced tHcy levels (17-21).…”

Vascular and connective tissue features in 5 Italian patients with homocystinuria

“…Controls were selected among apparently healthy Italian subjects with no history of sudden death, without venous thrombosis, cardiovascular, skeletal or eyes Marfan or homocystinuric manifestations. Biochemical and genetic factors predisposing to thrombotic events were evaluated as previously reported [9][10][11][12]. Genomic DNA mutation analysis of CBS gene (Table 1) was performed [13].…”