Predictors of worsening insulin sensitivity in postmenopausal women

Goodrow, Gwen J.; L'Hommedieu, Georgia D.; Gannon, Barbara; Sites, Cynthia K.

doi:10.1016/j.ajog.2005.07.046

Cited by 9 publications

(6 citation statements)

References 18 publications

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“…The effect of HRT on body composition and insulinstimulated glucose disposal in early postmenopausal women has been reported previously by our group (7), and predictors of worsening insulin sensitivity (including age, years since menopause, lipids, family history of diabetes) has also been reported (8). To be included in the present study, volunteers were required to have adequate serum for additional studies of leptin, adiponectin, CRP, and IL-6 at baseline and at 1 year; all volunteers who met this criteria were included in the present study.…”

Section: Subjectssupporting

confidence: 65%

“…Hormone replacement therapy has been proposed to ameliorate the increased central body fat and insulin resistance in postmenopausal women. Studies evaluating the effect of HRT on glucose disposal in postmenopausal women have led to mixed results depending on the regimen used (7)(8)(9)(10)(11)(12)(13)(14). However, studies evaluating HRT with combined estrogen and continuous progestin demonstrated a decrease in insulin sensitivity without affecting body composition (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

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Insulin resistance with hormone replacement therapy: associations with markers of inflammation and adiposity

Cooper

Burger

Toth

et al. 2007

American Journal of Obstetrics and Gynecology

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Objective-To determine if insulin resistance associated with combination hormone replacement therapy (HRT) is mediated by changes in serum markers of inflammation or in serum adipocyte hormones.Study design-Forty-five postmenopausal women, aged 55 ± 7 years, were examined from a randomized, double-blind placebo-controlled trial evaluating the effect of HRT on insulin-stimulated glucose disposal and body composition. Volunteers were randomized to conjugated estrogens 0.625 mg plus medroxyprogesterone acetate 2.5 mg vs. placebo for 1 year. At baseline and at 1 year, body composition was assessed by dual photon x-ray absorptiometry scans (DEXA); body fat distribution was measured by CT scans at the L4/L5 vertebral disc space; insulin sensitivity was measured by euglycemic hyperinsulinemic clamp; interleukin-6 (IL-6), leptin and adiponectin were measured by ELISA; and c-reactive protein (CRP) was measured by RIA.Results-HRT increased CRP by 121% compared to a 32% increase with placebo (p=0.03); HRT decreased glucose disposal by 17% compared to no change with placebo (p=0.04) as reported previously. HRT did not affect body composition, body fat distribution, IL-6, leptin, or adiponectin. The increase in CRP did not correlate with the decrease in glucose disposal in the HRT group (R=0.11, p=0.65).Conclusion-Treatment with HRT for one year increases CRP, but does not alter IL-6, adiponectin, or leptin. The change in CRP was not, however, related to the decrease in glucose disposal with HRT treatment.

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Section: Subjectssupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Insulin resistance with hormone replacement therapy: associations with markers of inflammation and adiposity

Cooper

Burger

Toth

et al. 2007

American Journal of Obstetrics and Gynecology

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“…Several studies have suggested a reduced incidence of T2D in postmenopausal women receiving hormonal therapies. However, the question of whether the benefit may occur through a reduction in insulin resistance is uncertain (Goodrow et al, 2006; Margolis et al, 2004). In a systematic review, Ding et al suggested that the influence of endogenous sex hormones on T2D risk is a function of gender (Ding et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Risk factors of type 2 diabetes among Korean adults: The 2001 Korean national health and nutrition examination survey

Chung

Pérez‐Escamilla

2009

Nutr Res Pract

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This study aimed to identify risk factors for type 2 diabetes (T2D) in Korea, a rapidly changing country. Data of 5,132 adults aged 20-85 were used from the 2001 Korean Health and Nutrition Examination Survey. Multiple logistic regression was carried out to identify risk factors for T2D. Three models were specified: (i) socioeconomic and demographic factors (model 1: age, gender, education, poverty income ratio, employment), (ii) behavioral risk factors and covariates (model 2: obesity, physical activity, smoking, alcohol drinking, dietary quality, family history of T2D, co-morbidity) and (iii) socioeconomic, demographic, and behavioral factors (model 3). The prevalence of T2D was 7.4%. Less education (OR 1.41, 95% CI 1.08-1.84), age (OR 2.19, 95% CI 1.56-3.08 in 40-59 yrs, OR 4.05, 95% CI 2.76-5.95 in 60 yrs + comparing to 20-39 yrs) and abdominal obesity (OR 2.24, 95% CI 1.79-2.82) were risk factors for T2D even after controlling for other factors simultaneously. There was a significant association of T2D with ever smoking (OR 1.34, 95% CI 1.06-1.67). The relationship of age with T2D was modified by gender in model 1 and the relationship of smoking with T2D was modified by obesity in model 2. Less educated, older, obese or ever smokers were more likely to have T2D. Gender mediated the relationship of age, and obesity mediated the relationship of smoking, with T2D. Intervention programs for T2D in Korea should take the interactions among risk factors into account.

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“…Some of this risk may be related to changes in body composition, body fat distribution, and insulin sensitivity. Also, after menopause, climacteric women whose estradiol status is low have a decreased platelet activation status compared with premenopausal women [1] . Insulin sensitivity decreases after menopause, thus increasing the risk of diabetes and cardiovascular disease [1,2] .…”

Section: Introductionmentioning

confidence: 99%

“…Also, after menopause, climacteric women whose estradiol status is low have a decreased platelet activation status compared with premenopausal women [1] . Insulin sensitivity decreases after menopause, thus increasing the risk of diabetes and cardiovascular disease [1,2] . Studies evaluating the effect of hormone replacement therapy (HRT) on glucose disposal in postmenopausal women have led to mixed results, depending on the regimen used [3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

Effects of Hormone Replacement Therapy on Insulin Resistance and Platelet Function Tests

Saraç

Saydam²,

Şahin³

et al. 2008

Med Princ Pract

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Objectives: The aim of this study was to evaluate measures of insulin resistance and platelet function in postmenopausal women with oral or transdermal hormone replacement therapy (HRT). Subjects and Methods: Eighty women divided into four groups of 20 each were enrolled in the study. Group 1: postmenopausal hysterectomized women who received only transdermal estradiol (13.9 mg/12.5 cm²); group 2: women with intact uterus who were treated with estrogen-progestin combination (HRT); group 3: postmenopausal women who were treated with the selective estrogen receptor modulator tibolone, and group 4: women who were not taking any drugs for HRT were chosen as a control group (group 4). Results: In group 2, homeostasis model assessment of insulin resistance and fasting insulin levels were 2.90 ± 0.37 and 9.3 ± 3.0 µU/ml, respectively, prior to administration of HRT. These levels were reduced to 1.91 ± 0.41 (p = 0.001) and 7.1 ± 2.7 µU/ml (p = 0.002), respectively, after drug therapy. Mean levels of high-sensitivity C-reactive protein (hsCRP) were decreased with HRT only in group 2 (p = 0.002). No changes for biochemical and hematological parameters were observed in the other groups. Platelet function tests showed no differences after HRT in any group. Conclusions: Estrogen-progestin combination HRT decreased measures of insulin resistance and hsCRP levels, but had no effect on platelet function tests in postmenopausal women.

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Predictors of worsening insulin sensitivity in postmenopausal women

Cited by 9 publications

References 18 publications

Insulin resistance with hormone replacement therapy: associations with markers of inflammation and adiposity

Insulin resistance with hormone replacement therapy: associations with markers of inflammation and adiposity

Risk factors of type 2 diabetes among Korean adults: The 2001 Korean national health and nutrition examination survey

Effects of Hormone Replacement Therapy on Insulin Resistance and Platelet Function Tests

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