Predisposed obesity and long-term metabolic diseases from maternal exposure to fine particulate matter (PM2.5) — A review of its effect and potential mechanisms

Sun, Jun; Liu, Haoyin; Zhang, Cong; Liu, Xiaofang; Sun, Xiance; Chen, Xin; Yang, Guang; Wang, Ningning

doi:10.1016/j.lfs.2022.121054

Cited by 17 publications

(9 citation statements)

References 62 publications

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“…31,44 As for O3 and NO2, we observed contrast results as a positive effect of O3 and NO2 but a negative effect of PM2.5. In addition, compared with the other two exposure windows, the impacts of particulate matter (PM) (PM2.5 and PM10) were more evident in Period 3, suggesting that long-term exposure to PM2.5 and PM10 is likely to cause biological changes such as systemic oxidative stress, endocrine dysfunction and epigenetic changes, 45 which may further lead to adverse maternal effects such as decreased placental function. 46 Interestingly, the correlation between O3 concentration and biochemical/clinical pregnancy is opposite to the results for other pollutants.…”

Section: Discussionmentioning

confidence: 99%

Individual-level air pollutants exposure and pregnancy outcomes in patients who underwent assisted reproductive technology: A retrospective longitudinal cohort study

Fang,

Guo,

Jiang

et al. 2023

Preprint

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Background The effects of air pollution on the results of assisted reproductive technology (ART) treatment in terms of pregnancy outcomes were inconclusive. Methods We performed an individual-level retrospective longitudinal cohort study among 11,968 participants undergoing ART treatment from a general hospital in Hefei, China in 2013-20. Monthly mean concentrations of air pollutants [fine particulate matter (PM2.5), suspended particulate matter (PM10), ozone (O3), sulfur dioxide (SO2), Nitrogen dioxide (NO2) and carbon oxide (CO)] during 3 Periods were obtained from ChinaHighAirPollutants (CHAP) dataset: respective Periods 1, 2 and 3 refer to 90 days, one or two years prior to oocyte retrieval. Multiple logistic regression model was applied to explore the impact of air pollution on four ART results (biochemical pregnancy, clinical pregnancy, pregnancy loss, and live birth). Results We observed negative relationships of PM10, PM2.5, CO and SO2 exposures with pregnancy outcomes were more evident during one year exposure (Period 2). An interquartile range increment of ambient PM10, PM2.5, CO, and SO2 exposures during Period 2 was associated with respective decrements of 5.85% (aOR: 0.94, 95% CI: 0.90–0.99), 7.82% (aOR: 0.92, 95% CI: 0.88–0.97), 10.60% (aOR: 0.89, 95% CI: 0.82–0.93) and 12.38% (aOR: 0.88, 95% CI: 0.82–0.93) on clinical pregnancy, while O3 and NO2 showed positive associations. Associations were stronger in patients undergoing frozen embryo transfer, aged < 32 years, with normal BMI, employed status, one embryo transferred, and in warm season. Conclusions Our data show that long-term individual-level exposure to the air pollutants of PM10, PM2.5, CO, SO2 but not O3 or NO2, especially in one year exposure before oocyte retrieval, could have a negative impact on ART outcomes.

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Section: Discussionmentioning

confidence: 99%

Individual-level air pollutants exposure and pregnancy outcomes in patients who underwent assisted reproductive technology: A retrospective longitudinal cohort study

Fang,

Guo,

Jiang

et al. 2023

Preprint

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“…However, emerging evidence suggests a link between prenatal exposure to PM 2.5 and fetal overdevelopment. − Although the relevant biological mechanisms have not been fully understood, disorders of glucose and lipid metabolism have been suggested to play a role. Both epidemiological and toxicological evidence consistently shows that PM 2.5 may cause maternal metabolic dysfunction and disrupt normal lipid and glucose metabolic homeostasis, − which significantly contribute to fetal overdevelopment. , Additionally, these findings have been confirmed by accumulating epidemiological studies. − For instance, Shang et al and Li et al . found that prenatal exposure to PM 2.5 was significantly associated with an increased macrosomia risk in Xi’an and Yancheng, China, respectively.…”

Section: Introductionmentioning

confidence: 90%

Association of Fine Particulate Matter and Its Components with Macrosomia: A Nationwide Birth Cohort Study of 336 Chinese Cities

Huang

Luo

et al. 2023

Environ. Sci. Technol.

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To examine the associations between macrosomia risk and exposure to fine particulate matter (PM2.5) and its chemical components during pregnancy, we collected birth records between 2010 and 2015 in mainland China from the National Free Preconception Health Examination Project and used satellite-based models to estimate concentrations of PM2.5 mass and five main components, namely, black carbon (BC), organic carbon (OC), nitrate (NO3 –), sulfate (SO4 2–), and ammonium (NH4 +). Associations between macrosomia risk and prenatal exposure to PM2.5 were examined by logistic regression analysis, and the sensitive subgroups were explored by stratified analyses. Of the 3,248,263 singleton newborns from 336 cities, 165,119 (5.1%) had macrosomia. Each interquartile range increase in concentration of PM2.5 during the entire pregnancy was associated with increased risk of macrosomia (odds ratio (OR) = 1.18; 95% confidence interval (CI), 1.17–1.20). Among specific components, the largest effect estimates were found on NO3 – (OR = 1.36; 95% CI, 1.35–1.38) followed by OC (OR = 1.23; 95% CI, 1.22–1.24), NH4 + (OR = 1.22; 95% CI, 1.21–1.23), and BC (OR = 1.21; 95% CI, 1.20–1.22). We also that found boys, women with a normal or lower prepregnancy body mass index, and women with irregular or no folic acid supplementation experienced higher risk of macrosomia associated with PM2.5 exposure.

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“…Maternal exposure to ≤PM 2.5 predisposes adult male mice offspring to NAFLD and other long-term metabolic dysfunctions such as obesity, T2D, insulin resistance, hypertension, hyperlipidemia, and metabolic syndrome, likely affecting organogenesis and tissue functions [ 282 , 283 , 284 , 285 ]. In mice, prenatal exposure to diesel exhaust PM 2.5 (DEP) leads to increased lipogenesis and worsens fatty acid oxidation, favoring hepatic lipid deposition in the adult male offspring [ 286 ].…”

Section: Maternal Exposure To Pollutants and Developmental Origins Of...mentioning

confidence: 99%

Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution

Dolce

Torre

2023

Nutrients

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Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease and represents an increasing public health issue given the limited treatment options and its association with several other metabolic and inflammatory disorders. The epidemic, still growing prevalence of NAFLD worldwide cannot be merely explained by changes in diet and lifestyle that occurred in the last few decades, nor from their association with genetic and epigenetic risk factors. It is conceivable that environmental pollutants, which act as endocrine and metabolic disruptors, may contribute to the spreading of this pathology due to their ability to enter the food chain and be ingested through contaminated food and water. Given the strict interplay between nutrients and the regulation of hepatic metabolism and reproductive functions in females, pollutant-induced metabolic dysfunctions may be of particular relevance for the female liver, dampening sex differences in NAFLD prevalence. Dietary intake of environmental pollutants can be particularly detrimental during gestation, when endocrine-disrupting chemicals may interfere with the programming of liver metabolism, accounting for the developmental origin of NAFLD in offspring. This review summarizes cause–effect evidence between environmental pollutants and increased incidence of NAFLD and emphasizes the need for further studies in this field.

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Predisposed obesity and long-term metabolic diseases from maternal exposure to fine particulate matter (PM2.5) — A review of its effect and potential mechanisms

Cited by 17 publications

References 62 publications

Individual-level air pollutants exposure and pregnancy outcomes in patients who underwent assisted reproductive technology: A retrospective longitudinal cohort study

Individual-level air pollutants exposure and pregnancy outcomes in patients who underwent assisted reproductive technology: A retrospective longitudinal cohort study

Association of Fine Particulate Matter and Its Components with Macrosomia: A Nationwide Birth Cohort Study of 336 Chinese Cities

Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution

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