Predisposing factors of important invasive fungal coinfections in COVID-19 patients: a review article

Zia, Mohammadali; Goli, Mohammad

doi:10.1177/03000605211043413

Cited by 15 publications

(11 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This lipid membrane is absent in nonenveloped viruses. The nucleocapsid center is instead surrounded by other structural proteins that have been meticulously arranged into a spore‐like structure (Zia & Goli, 2021; Goli, 2020a, 2020b).…”

Section: Introductionmentioning

confidence: 99%

Review of proposed different irradiation methods to inactivate food‐processing viruses and microorganisms

Shahi

Khorvash

Goli

et al. 2021

Food Science & Nutrition

Self Cite

View full text Add to dashboard Cite

Viruses are intracellular parasitic obligates. They do not have the biochemical machinery (organelles and enzymes) to survive outside of living cells. They have a simple structure, with a nucleocapsid made up of a genome (i.e., DNA or RNA) and proteins. Viruses are divided into two types: enveloped and nonenveloped viruses. The nucleocapsid is enclosed by a lipid membrane in enveloped viruses, which is acquired during virus assembly from infected cells. This lipid envelope contains moieties that aid virus attachment and entry during subsequent infection cycles, such as glycoproteins (modified proteins). This lipid membrane is absent in nonenveloped viruses.

show abstract

Section: Introductionmentioning

confidence: 99%

Review of proposed different irradiation methods to inactivate food‐processing viruses and microorganisms

Shahi

Khorvash

Goli

et al. 2021

Food Science & Nutrition

Self Cite

View full text Add to dashboard Cite

show abstract

“…Elevation in IL‐1 and IL‐6 in severe COVID‐19 associated Aspergillus fumigatus infections is reportedly associated with a worse outcome 53 . Invasive mucormycosis patients elicit Mucorales‐specific T cells that are predominantly IFN‐γ producing CD8 T cells of central memory (CM) phenotype, IL‐4 producing CD8 T cells of effector memory (EM) phenotype, IL‐10 or IL‐17 producing CD4 and CD8 T cells of central memory (CM) phenotype, enhancing the fungicidal activity against Mucorales 54 .…”

Section: Discussionmentioning

confidence: 99%

Perturbations of immune landscape in COVID‐19 associated mucormycosis

Desai

Pradhan

Chougule

et al. 2022

Mycoses

View full text Add to dashboard Cite

Background: A rise in secondary fungal infections during the COVID-19 pandemic necessitates a deeper understanding of the associated immunological perturbations. Objectives: To evaluate the clinical and immunological characteristics observed in patients with COVID-19 associated mucormycosis (CAM) infection. Patients/ Methods: Cases of mucormycosis with or post-COVID-19 infection were compared with cases of acute COVID-19 and convalescent COVID-19. Lymphocyte subsets, cytokines and other laboratory markers were compared between the groups. Results:The frequency of proposed risk factors for CAM was diabetes mellitus (77%), recent history of steroid use (69%) and hypoxia during COVID-19 infection (52%).Iron metabolism was dysregulated in CAM patients with low TIBC and total iron. Further, CAM was accompanied with lymphopenia with drastic reduction in B cell counts; however, plasmablasts were not altered. Further, CAM patients had low immunoglobulin levels and antibodies specific to mucor peptide did not increase in CAM suggesting dysfunction in B-cell response. There was increase in activated effector cytotoxic CD8 T cells and NK cells in CAM compared with COVID-19 infection and healthy controls. Among T helper cells, Tregs were reduced and Th-1 frequency was

show abstract

“…[ 74 ]. Thus, Candida infections fatally increase the severity of infection among elderly COVID-19 patients and dangerously jeopardize their recovery from the disease [ 75 ].…”

Section: Impact Of Fungal Infections On Recoverymentioning

confidence: 99%

Post-COVID-19 Fungal Infection in the Aged Population

et al. 2023

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) infection is currently a great cause of concern for the healthcare sector around the globe. SARS-CoV-2 is an RNA virus that causes a serious infection that is associated with numerous adverse effects and multiple complications associated with different organs and systems during its pathogenic cycle in humans. Individuals affected by COVID-19, especially elderly populations and immunocompromised people, are greatly vulnerable to opportunistic fungal pathogens. Aspergillosis, invasive candidiasis, and mucormycosis are widespread fungal coinfections in COVID-19 patients. Other fungal infections that are rare but are exhibiting increased incidence in the current scenario include infections caused by Pneumocystis jirovecii, Histoplasma sp., Cryptococcus sp., etc. By producing virulent spores, these pathogens increase the severity of the disease and increase the morbidity and fatality rates in COVID-19 patients globally. These infections generally occur in patients recovering from COVID-19 infection, resulting in rehospitalization. Older and immunocompromised individuals are at higher risk of developing opportunistic fungal infections. This review focuses on understanding the opportunistic fungal infections prevalent in COVID-19 patients, especially elderly people. We have also highlighted the important preventive methods, diagnostic approaches, and prophylactic measures for fungal infections.

show abstract

Predisposing factors of important invasive fungal coinfections in COVID-19 patients: a review article

Cited by 15 publications

References 46 publications

Review of proposed different irradiation methods to inactivate food‐processing viruses and microorganisms

Review of proposed different irradiation methods to inactivate food‐processing viruses and microorganisms

Perturbations of immune landscape in COVID‐19 associated mucormycosis

Post-COVID-19 Fungal Infection in the Aged Population

Contact Info

Product

Resources

About