Preditores de viabilidade em pacientes com resposta negativa à ecocardiografia de estresse com dobutamina de baixa dose

Background Cardiorenal complications are common in patients with dysmetabolism and diabetes. The present study aimed to examine if a nonhuman primate (NHP) model with spontaneously developed metabolic disorder and diabetes develops similar complications to humans, such as proteinuria and cardiac dysfunction at resting condition or diminished cardiac functional reserve following dobutamine stress echocardiography (DSE). Methods and Results A total of 66 dysmetabolic and diabetic cynomolgus (Macaca fascicularis) NHPs were enrolled to select 19 NHPs (MetS) with marked metabolic disorders and diabetes (fasting blood glucose: 178+18 vs. 61+3

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Diastolic dysfunction and impaired cardiac output reserve in dysmetabolic nonhuman primate with proteinuria

Wikström

Liu

Whatling

et al. 2021

Journal of Diabetes and its Complications

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Preditores de viabilidade em pacientes com resposta negativa à ecocardiografia de estresse com dobutamina de baixa dose

Abstract: Background: Low-dose dobutamine stress echocardiography is specific for predicting reversible contractility dysfunction, but its sensitivity is lower than ideal.

Cited by 1 publication

References 28 publications

Diastolic dysfunction and impaired cardiac output reserve in dysmetabolic nonhuman primate with proteinuria

Diastolic dysfunction and impaired cardiac output reserve in dysmetabolic nonhuman primate with proteinuria

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