Prednisolone protects against TNF-A induced disturbance of intestinal epithelial tight junction barrier

Ecology of Danger‐dependent Cytokine‐boosted Spontaneous Abortion in the CBA × DBA/2 Mouse Model. I. Synergistic Effect of LPS and (TNF‐α + IFN‐γ) on Pregnancy Loss

“…Based upon previous studies 31 where increased abortion rates were boosted by increasing intestinal permeability with the drug indomethacin (a non‐steroidal anti‐inflammatory drug), and reduced by oral antibiotic treatment, we suspect an intestinal source of the LPS. One cannot formally exclude the possibility of increased vaginal absorption of LPS following cytokines, but that is unlikely to be a sole source given a variety of experimental data showing manoeuvres that increase TNF‐ α and related cytokines can increase intestinal permeability and absorption of molecules from the intestinal flora 32–36 …”