Prednisone acetate modulates Th1/Th2 and Th17/Treg cell homeostasis in experimental autoimmune uveitis via orchestrating the Notch signaling pathway

Zhou, Mengxian; Qu, Ruyi; Yin, Xuewei; Qiu, Yan; Peng, Yuan; Liu, Bin; Gao, Yanbin; Bi, Hongsheng; Guo, Dadong

doi:10.1016/j.intimp.2023.109809

Cited by 10 publications

(3 citation statements)

References 42 publications

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“…Activation of the TLR4-MyD88-NF-κB signalling pathway can significantly increase the expression of IL-6 and CCL17 and significantly decrease the expression of TGF-β, resulting in the increase of Th17 cells and the decrease of Treg cells ( 70 ). Studies have found that inhibiting the activation of Notch signalling pathway can effectively reduce the response of Th17 cells, down-regulate the expression of Notch1, DLL4, IL-17 and the transcription of ROR γt, reduce the level of Th17 cells, downregulate Notch1, DLL4, and IL-17 expressions and ROR γt transcription, reduce the level of Th17 cells, and effectively restore the balance of Th17/Treg ( 71 , 72 ). In addition, inhibiting the expression of p-STAT3 in the IL-6/JAK/STAT3 signalling pathway can significantly inhibit the differentiation of CD4+T cells into Th17 cells, downregulate the secretion of IL-17A, and effectively regulate the balance between Th17 and Treg cells ( 73 ).…”

Section: Regulatory Factors Associated With Th17 and Treg Differentia...mentioning

confidence: 99%

Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases

Wang,

Sun,

Wang

et al. 2024

Front. Immunol.

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Rheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-immune diseases. The imbalance between helper (Th17) and regulatory T cells (Tregs) produced during differentiation of CD4+ T cells plays a key regulatory role in bone remodelling disorders in RA and PMOP. However, the specific regulatory mechanism of this imbalance in bone remodelling in RA and PMOP has not been clarified. Identifying the regulatory mechanism underlying the Th17/Treg imbalance in RA and PMOP during bone remodelling represents a key factor in the research and development of new drugs for bone immune diseases. In this review, the potential roles of Th17, Treg, and Th17/Treg imbalance in regulating bone remodelling in RA and PMOP have been summarised, and the potential mechanisms by which probiotics, traditional Chinese medicine compounds, and monomers maintain bone remodelling by regulating the Th17/Treg balance are expounded. The maintenance of Th17/Treg balance could be considered as an therapeutic alternative for the treatment of RA and PMOP. This study also summarizes the advantages and disadvantages of conventional treatments and the quality of life and rehabilitation of patients with RA and PMOP. The findings presented her will provide a better understanding of the close relationship between bone immunity and bone remodelling in chronic bone diseases and new ideas for future research, prevention, and treatment of bone immune diseases.

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Section: Regulatory Factors Associated With Th17 and Treg Differentia...mentioning

confidence: 99%

Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases

Wang,

Sun,

Wang

et al. 2024

Front. Immunol.

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“…Immune active substances with HLA to T helper cells will stimulate T cell to activate, leading to differentiation into Th2, Th1, Th17, and Treg cells ( 75 , 160 – 162 ). Th2 cells as control factors of Th1 cells, secretion of IL - 4 and anti-inflammatory factors such as IL - 10, and suppress Th1 tissue damage caused by hyperactivity ( 161 , 163 ). Th1 cells produce IFN-γ and IL-2, which are subject to regulation by other cytokines, such as IL-17 and IL-10 ( 164 ).…”

Section: The Application Strategies Of Immunopeptides In Ocular Diseasesmentioning

confidence: 99%

Immunopeptides: immunomodulatory strategies and prospects for ocular immunity applications

Tang,

Qu,

Ning

et al. 2024

Front. Immunol.

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Immunopeptides have low toxicity, low immunogenicity and targeting, and broad application prospects in drug delivery and assembly, which are diverse in application strategies and drug combinations. Immunopeptides are particularly important for regulating ocular immune homeostasis, as the eye is an immune-privileged organ. Immunopeptides have advantages in adaptive immunity and innate immunity, treating eye immune-related diseases by regulating T cells, B cells, immune checkpoints, and cytokines. This article summarizes the application strategies of immunopeptides in innate immunity and adaptive immunity, including autoimmunity, infection, vaccine strategies, and tumors. Furthermore, it focuses on the mechanisms of immunopeptides in mediating ocular immunity (autoimmune diseases, inflammatory storms, and tumors). Moreover, it reviews immunopeptides’ application strategies and the therapeutic potential of immunopeptides in the eye. We expect the immune peptide to get attention in treating eye diseases and to provide a direction for eye disease immune peptide research.

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“…1 b). In uveitis, research studies have detected the co-existence of initiators of the classic activation and the alternative activation of microglia in the aqueous humor of clinical patients and in the retina of experimental uveitis animal models [ 25 – 27 ], which suggests the possibility of microglial M1/M2 differentiation during the pathology of uveitis.…”

Section: Heterogeneity Of Retinal Microgliamentioning

confidence: 99%

Relationship between Uveitis and the Differential Reactivity of Retinal Microglia

Gao,

Jin,

Zhou

et al. 2023

Ophthalmic Res

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Uveitis, a complicated group of ocular inflammatory diseases, can be affected by massive pathogenic contributors such as infection, autoimmunity, and genetics. Although it is well known that many pathological changes, including disorders of the immune system and disruption of the blood-retinal barrier, count much in the onset and progression of uveitis, there is a paucity of safe and effective treatments, which has exceedingly hindered the appropriate treatment of uveitis. As innate immune cells in the retina, microglia occupy a salient position in retinal homeostasis. Many studies have reported the activation of microglia in uveitis and the mitigation of uveitis by interfering with microglial reactivity, which strongly implicates microglia as a therapeutic target. However, it has been increasingly recognized that microglia are a nonhomogeneous population under different physiological and pathological conditions, which makes it essential to thoroughly have knowledge of their specific characteristics. The paper outlines the various properties of activated microglia in uveitis, summarizes the connections between their polarization patterns and the manifestations of uveitis, and ultimately is intended to enhance the understanding of microglial versatility and expedite the exploration of promising strategies for visual protection.

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Prednisone acetate modulates Th1/Th2 and Th17/Treg cell homeostasis in experimental autoimmune uveitis via orchestrating the Notch signaling pathway

Cited by 10 publications

References 42 publications

Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases

Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases

Immunopeptides: immunomodulatory strategies and prospects for ocular immunity applications

Relationship between Uveitis and the Differential Reactivity of Retinal Microglia

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