Prednisone-Glycosuria Test for Prediabetes

Joplin, G. F.; Fraser, Russell; Keeley, Kaitlin

doi:10.1016/s0140-6736(61)92368-6

Cited by 33 publications

(13 citation statements)

References 24 publications

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“…The prednisone-glycosuria test is a convenient method, which reveals chemical diabetes [5]. In our experience, reported in this paper, prednisone induced glycosuria in hospitalized psoriatics more often than in most dermatological inpatients.…”

mentioning

confidence: 63%

Prednisone-glycosuria Test in Psoriasis

Rechardt¹,

Lassus²

1969

Dermatology

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mentioning

confidence: 63%

Prednisone-glycosuria Test in Psoriasis

Rechardt¹,

Lassus²

1969

Dermatology

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“…So far we have measured insulin levels in only a few subjects designated as latent diabetics by their abnormal glycosuria and hyperglycaemia in a prednisone glycosuria test (Joplin, Fraser & Kelley, 1961). Insulin levels in these subjects show indi¬ cations of increased basal or fasting insulin secretion together with diminished insulin reserve, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…(mean 17-9 mm. ), and (Joplin et al 1961): positive when overnight urine contained more than 60 mg. glucose/hr. and midnight blood sugar was greater than 128 mg./100 ml.…”

Section: Methodsmentioning

confidence: 99%

Serum and Urine Insulin in Late Pregnancy and in a Few Pregnant Latent Diabetics

Trayner¹,

Welborn²,

Rubenstein³

et al. 1967

Journal of Endocrinology

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As measured both by immunoassay and bioassay during a glucose tolerance test (50 g.) on ten subjects in the third trimester of pregnancy, the serum insulin levels fasting, 1 and 2 hr. after glucose were raised at least threefold compared with the levels in 23 non-pregnant women.The renal clearance of immunoassayable insulin was lower than that in the non-pregnant state (the mean in the pregnant subjects was 0\m=.\18 ml./min. compared with 0\m=.\45 ml ./mi n.in the normal non-pregnant subjects). In the same subjects the mean serum non-suppressible insulin-like activity, which is unaltered by oral glucose, was 1\m=.\5times higher than the non-pregnant mean level, but this difference was not significant.Four pregnant latent diabetics, tested similarly in the latter part of pregnancy, showed even higher fasting serum insulin levels than the normal pregnant subjects, but a lessened response to the same glucose load.

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“…We then examined a group of patients who are predisposed to develop the diabetic syndrome, namely latent diabetes (defined as a mild abnormality in the glucose tolerance test or prednisone glycosuria test (Joplin, Fraser & Keeley, 1961) with no clinical evidence of diabetes). The rates of isotope incorporation into neutral lipid in seven latent diabetics are presented in Fig.…”

Section: Latent Diabetesmentioning

confidence: 99%

A Defect of Glucose Utilization in Adipose Tissue of Adult Diabetics and in Some Conditions Which May Predispose to Diabetes

Galton¹,

Wilson²

1970

Clinical Science

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1. The effects of glucose, glucose 6-phosphate, and L-glycerol 3-phosphate on the incorporation of [ l-14C]palmitate into neutral lipid have been studied in homogenates of adipose tissue obtained from adult diabetics and control patients. In the diabetic, glucose, glucose 6-phosphate and L-glycerol3-phosphate supported incorporation of 19,27 and 62% of total counts respectively; whereas in paired non-diabetic controls the respective values were 78, 80 and 84%.2. Confirmation of these results were provided by finding slower rates of conversion of [U-14C]glucose into phosphate esters in diabetic adipose tissue compared to paired non-diabetic controls. Rates were improved but not restored to normal by treatment of diabetic patients with insulin.3. These results could not be explained on the basis of differences in isotope dilution in precursor pools or to the presence of raised levels of free fatty acids in diabetic tissue. 4. A group of latent diabetics showed a pattern of substrate utilization more like fully developed diabetes than non-diabetic controls. Rates of glucose phosphorylation were slower in latent diabetics than in paired controls.5. Studies were also performed with homogenates of adipose tissue prepared from patients with Cushing's disease, obesity and pregnancy, these groups being predisposed to develop adult diabetes.6. In Cushing's disease (eight patients) glucose, glucose 6-phosphate and L-glycerol 3-phosphate supportedincorporation of 9f 1 (13), 19.2k3-9 (10) and23-2&3-3 (9) % of total counts at 2 hr respectively; whereas in paired controls respective values were 19.7k3.4 (lo), 25.7+2-8 (10) and 26.4k2.9 (lo)%. Support for these results was provided by finding slower rates (by about 50%) of conversion of [U-'4C]glucose into phosphate esters in tissue from Cushing's disease compared to paired controls. 7. Ten obese patients with no clinical evidence of diabetes showed a pattern of sub-

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Prednisone-Glycosuria Test for Prediabetes

Cited by 33 publications

References 24 publications

Prednisone-glycosuria Test in Psoriasis

Prednisone-glycosuria Test in Psoriasis

Serum and Urine Insulin in Late Pregnancy and in a Few Pregnant Latent Diabetics

A Defect of Glucose Utilization in Adipose Tissue of Adult Diabetics and in Some Conditions Which May Predispose to Diabetes

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