Prednisone inhibits late asthmatic reactions and airway inflammation induced by toluene diisocyanate in sensitized subjects

Boschetto, Pierà; Fabbri, Leonardo M.; Zocca, E.; Milani, G. F.; Pivirotto, F; Vecchio, A. Dal; Plebani, Mario; Mapp, C. E.

doi:10.1016/0091-6749(87)90028-5

Cited by 63 publications

(35 citation statements)

References 24 publications

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“…These findings are consistent with pathophysiologic changes found in TDI-induced asthma in human subjects. 3,4,18,19 Thus we believe that this model will be very useful for further investigations into TDI-induced asthma.…”

Section: Discussionmentioning

confidence: 99%

“…3,4,20 In TDI-induced asthma in human subjects, neutrophilia in BAL fluid has been found in association with asthmatic reactions induced by isocyanate challenge. 21 Neutrophils could be an important source of proinflammatory cytokines and proteolytic enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 This inflammation is associated with infiltration of lymphocytes, eosinophils, and neutrophils into the bronchial lumen. 3,4 Airway remodeling, which often occurs in the bronchial tree, probably arises as a consequence of inflammatory processes.…”

mentioning

confidence: 99%

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A murine model of toluene diisocyanate–induced asthma can be treated with matrix metalloproteinase inhibitor

Lee¹,

Song²,

Lee³

et al. 2001

Journal of Allergy and Clinical Immunology

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Background: Toluene diisocyanate (TDI) is a leading cause of occupational asthma. TDI-induced asthma is an inflammatory disease of the airways that is associated with airway remodeling. However, there are little data available on the role of matrix metalloproteinases (MMPs) in TDI-induced asthma. Objective: We evaluated whether MMP-9 participates in the airway inflammation in TDI-induced asthma. An additional aim of the present study was to determine whether MMP inhibitors could be effective therapeutic agents for TDIinduced asthma. Methods: We developed a murine model of TDI-induced asthma to examine the involvement of MMPs by performing 2 sensitizations with 3% TDI and 1 challenge with 1% TDI using ultrasonic nebulization. Toluene diisocyanate (TDI), a low-molecular-weight compound widely used in the production of polyurethane foams, automobile paints, varnishes, and related products, is a leading cause of occupational asthma. 1,2 TDIinduced asthma is characterized by hyperresponsiveness and inflammation of the airways. 2,3 This inflammation is associated with infiltration of lymphocytes, eosinophils, and neutrophils into the bronchial lumen. 3,4 Airway remodeling, which often occurs in the bronchial tree, probably arises as a consequence of inflammatory processes.The extracellular matrix is a dynamic structure, and its homeostasis depends on an equilibrium between synthesis and degradation of extracellular matrix components. A balance between the expression of proteases and antiproteases, particularly the matrix metalloproteinases (MMPs) and their inhibitors, maintains this homeostasis under normal conditions. The expression of these same proteases and antiproteases is critical in tissue repair and remodeling in some pulmonary inflammatory diseases. [5][6][7][8] In allergic asthma, the mechanisms of remodeling of the bronchial tree caused by extracellular matrix deposition are well characterized. Of the MMP family, MMP-9 is the major proteinase that induces bronchial remodeling in asthma. 9,10 In addition, MMP-9 induces the migration of eosinophils and neutrophils across basement membranes. 11,12 Recently, MMPs were reported to play a crucial role in the infiltration of ovalbumin-induced airway inflammatory cells and the induction of airway hyperresponsiveness in a murine model of asthma. 13 However, there are little data available on the role of MMPs in TDIinduced asthma.In the present study we developed a murine model of TDI-induced asthma to examine the involvement of

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A murine model of toluene diisocyanate–induced asthma can be treated with matrix metalloproteinase inhibitor

Lee¹,

Song²,

Lee³

et al. 2001

Journal of Allergy and Clinical Immunology

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“…Желательно также отменить ингаляционные глюко кортикостероиды (иГКС). В исследованиях показа но, что при воздействии ингаляционных и перораль ных кортикостероидов в дозозависимом режиме значительно ослабляются бронхиальная реакция на аллергены, особенно поздняя, и связанная с ней НБГр, хотя и не подавляется полностью реакция бронхов [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]. Протективный эффект иГКС при аллерген индуцированной ранней реакции, эозино филия дыхательных путей и повышение НБГр час тично или полностью сохраняются в течение 12 ч после прекращения терапии [48].…”

Section: меры предосторожностиunclassified

Challenge inhalation tests in the diagnosis of occupational asthma: the guidelines of European Respiratory Society

Редакционная¹

2015

Pulʹmonologiâ (Mosk.)

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РезюмеВ данном документе содержатся клинические рекомендации по проведению ингаляционных тестов для диагностики профессиональ ной бронхиальной астмы (ПБА). Представленные Рекомендации разработаны на основе систематического обзора литературы, исследо ваний, проводившихся в крупных медицинских центрах Европы, материалов конференций и мнений экспертов. В статье подробно описана пошаговая процедура выполнения специфических ингаляционных провокационных тестов (СИПТ), в т. ч. требования без опасности, способы ингаляционной доставки провоцирующего вещества и методы оценки результатов. Также обсуждаются недостатки этой процедуры. Ингаляционные провокационные тесты должны выполняться только в условиях медицинских учреждений, где имеет ся опыт подобного тестирования. В тестах также должны использоваться контрольные провокационные вещества, доза провоцирующе го вещества должна повышаться постепенно при тщательном наблюдении пациента во время исследования и как минимум в течение 6 ч после его окончания. При соблюдении всех требований побочные эффекты СИПТ встречаются редко. Положительным результатом теста считается снижение объема форсированного выдоха за 1 ю секунду на ≥ 15 %исх. Иногда положительный результат может объяс няться неспецифической бронхиальной гиперреактивностью, эозинофилией мокроты или повышением содержания оксида азота в вы дыхаемом воздухе. Ингаляционные провокационные тесты обладают высокой чувствительностью и специфичностью, поэтому счита ются решающим методом диагностики ПБА. Ключевые слова: специфические ингаляционные провокационные тесты, профессиональная бронхиальная астма, диагностика, методи ка, пиковая скорость выдоха, объем форсированного выдоха за 1 ю секунду. Challenge inhalation tests in the diagnosis of occupational asthma: the guidelines of European Respiratory Society SummaryThis consensus statement provides practical recommendations for specific inhalation challenge (SIC) in the diagnosis of occupational asthma. They are derived from a systematic literature search, a census of active European centres, a Delphi conference and expert consensus. This article details each step of a SIC, including safety requirements, techniques for delivering agents, and methods for assessing and interpreting bronchial responses. The limitations of the procedure are also discussed. Testing should only be carried out in hospitals where physicians and healthcare professionals have appropriate expertise. Tests should always include a control challenge, a gradual increase of exposure to the suspected agent, and close moni toring of the patient during the challenge and for at least 6 hours afterwards. In expert centres, excessive reactions provoked by SIC are rare. A pos itive response is defined by a fall in forced expiratory volume in 1 second ≥ 15 % from baseline. Equivocal reactions can sometimes be clarified by finding changes in nonspecific bronchial responsiveness, sputum eosinophils or exhaled nitric oxide. The sensitivity and specificity of SIC are high but not easily quantified, as the method is usually...

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“…Sin embargo, los estudios experimentales y el lavado broncoalveolar apoyan la hipótesis de que sea inflamatoria 35 . Respuesta dual, es una respuesta doble, con un descenso inicial y otro a las 3-8 h.…”

Section: Provocación Bronquial Específicaunclassified

Asma ocupacional

Cebollero

Echegoyen

Santolaria

2005

Anales Sis San Navarra

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RESUMENAsma ocupacional es aquella entidad que se desarrolla por causas o condiciones derivadas de un determinado medio laboral y no por estímulos que se encuentran fuera del trabajo. El asma ocupacional constituye hoy en día la enfermedad respiratoria ocupacional más frecuente en la mayoría de los países industrializados y se calcula que la proporción de nuevos casos de asma atribuibles a la exposición laboral se sitúa en torno al 10-15%.Puede desarrollarse tanto por un mecanismo inmunológico como no inmunológico. En su desarrollo influyen el tipo de agente al que se está expuesto, el nivel y modo de exposición y factores genéticos de susceptibilidad. En el proceso diagnóstico concurre la confirmación de que el paciente tiene asma bronquial y la confirmación de que ésta se produce por causa laboral. Como demuestra la historia natural de la enfermedad, un diagnóstico precoz y las consiguientes acciones posteriores redundan en un mejor pronóstico de la misma.Palabras clave. Asma. Enfermedades ocupacionales. Exposición laboral. ABSTRACTOccupational asthma is an entity caused by conditions deriving from a certain work milieu and not from stimuli found outside the workplace. Nowadays, occupational asthma is the most frequent respiratory occupational disease in the majority of the industrialised countries and it is estimated that the proportion of new cases of asthma that can be attributed to exposure at work is around 10-15%.It can be developed due to an immunological mechanism or to a non-immunological mechanism. Influential in its development are the type of agent exposed to, the level and form of exposure and genetic factors of susceptibility. In the diagnostic process there is a concurrent confirmation that the patient has bronchial asthma and that this has been caused by occupational reasons. As shown by the natural history of the disease, an early diagnosis and the consequent posterior actions result in an improved prognosis.

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Prednisone inhibits late asthmatic reactions and airway inflammation induced by toluene diisocyanate in sensitized subjects

Cited by 63 publications

References 24 publications

A murine model of toluene diisocyanate–induced asthma can be treated with matrix metalloproteinase inhibitor

A murine model of toluene diisocyanate–induced asthma can be treated with matrix metalloproteinase inhibitor

Challenge inhalation tests in the diagnosis of occupational asthma: the guidelines of European Respiratory Society

Asma ocupacional

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